Retroviral proteases and their roles in virion maturation
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journal
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May 2015 |
Structure-based design of AIDS drugs and the development of resistance
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journal
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August 2002 |
Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV
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journal
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January 2012 |
Structure Based Drug Design for HIV Protease: From Molecular Modeling to Cheminformatics
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journal
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May 2007 |
Identification of HIV Inhibitors Guided by Free Energy Perturbation Calculations
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journal
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March 2012 |
Targeting structural flexibility in HIV-1 protease inhibitor binding
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journal
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February 2007 |
Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells
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journal
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January 2013 |
Basic concepts in RNA virus evolution.
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journal
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June 1996 |
Predictors of HIV Drug‐Resistance Mutations in a Large Antiretroviral‐Naive Cohort Initiating Triple Antiretroviral Therapy
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journal
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February 2005 |
Higher Rates of Viral Suppression with Nonnucleoside Reverse Transcriptase Inhibitors Compared to Single Protease Inhibitors Are Not Explained by Better Adherence
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journal
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October 2004 |
Highly resistant HIV-1 proteases and strategies for their inhibition
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journal
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June 2015 |
Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier
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journal
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October 2007 |
Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors
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journal
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May 2011 |
Enhanced Stability of Monomer Fold Correlates with Extreme Drug Resistance of HIV-1 Protease
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journal
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October 2013 |
HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements
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journal
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March 2012 |
Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20
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journal
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March 2015 |
Design of gem -Difluoro- bis -Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation
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journal
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October 2014 |
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes
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journal
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February 2010 |
Exploring the drug resistance of V32I and M46L mutant HIV-1 protease to inhibitor TMC114: Flap dynamics and binding mechanism
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journal
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March 2015 |
“Wide-Open” 1.3 Å Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target
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journal
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December 2005 |
Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease
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journal
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May 2008 |
Molecular dynamics simulations of HIV-1 protease with peptide substrate
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journal
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January 1994 |
Stiffness and energy conservation in molecular dynamics: An improved integrator
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journal
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September 1993 |
Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bio-active conformations
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journal
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January 2012 |
Improved Parameters for Generating Partial Charges: Correlation with Observed Dipole Moments
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journal
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September 1999 |
Molecular mechanics calculations on HIV-1 protease with peptide substrates correlate with experimental data
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journal
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January 1996 |
Molecular mechanics analysis of drug-resistant mutants of HIV protease
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journal
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June 1999 |
Molecular dynamics simulations of 14 HIV protease mutants in complexes with indinavir
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journal
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September 2004 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Phaser crystallographic software
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journal
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July 2007 |
Macromolecular TLS Refinement in REFMAC at Moderate Resolutions
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book
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January 2003 |
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
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journal
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May 1997 |
Version 1.2 of the Crystallography and NMR system
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journal
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October 2007 |
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
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journal
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November 2004 |
High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains
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journal
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April 2004 |
Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling
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journal
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May 2009 |
Insights into the functional role of protonation states in the HIV-1 protease-BEA369 complex: molecular dynamics simulations and free energy calculations
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journal
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March 2009 |
Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters: HIV protease mutants altering hydrophobic clusters
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journal
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August 2010 |
Energetic basis for drug resistance of HIV-1 protease mutants against amprenavir
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journal
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February 2012 |
Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.
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journal
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November 1990 |
How does a symmetric dimer recognize an asymmetric substrate? a substrate complex of HIV-1 protease
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journal
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September 2000 |
Conformational flexibility in the flap domains of ligand-free HIV protease
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journal
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July 2007 |
HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: Possible contributions to drug resistance and a potential new target site for drugs
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journal
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April 2004 |
Efficiency of a second-generation HIV-1 protease inhibitor studied by molecular dynamics and absolute binding free energy calculations
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journal
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June 2004 |
Bio3d: an R package for the comparative analysis of protein structures
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journal
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August 2006 |
Molecular dynamics and protein function
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journal
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May 2005 |
Protein Flexibility and Enzymatic Catalysis
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book
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May 2012 |
HIV-1 Protease Substrate Binding and Product Release Pathways Explored with Coarse-Grained Molecular Dynamics
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journal
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June 2007 |
Role of Conformational Fluctuations in the Enzymatic Reaction of HIV-1 Protease
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journal
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May 2002 |
Cooperative fluctuations of unliganded and substrate-bound HIV-1 protease: A structure-based analysis on a variety of conformations from crystallography and molecular dynamics simulations
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journal
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May 2003 |
Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps
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journal
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April 2014 |
Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease
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journal
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December 2013 |
Global Dynamics of Proteins: Bridging Between Structure and Function
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journal
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April 2010 |
Correlated motions are a fundamental property of β-sheets
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journal
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June 2014 |