skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)

Journal Article · · Bioorganic and Medicinal Chemistry

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1250600
Journal Information:
Bioorganic and Medicinal Chemistry, Journal Name: Bioorganic and Medicinal Chemistry Vol. 23 Journal Issue: 17; ISSN 0968-0896
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English
Citation Metrics:
Cited by: 53 works
Citation information provided by
Web of Science

References (31)

Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage journal August 2003
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia journal November 2012
Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist journal September 2013
Comparisons of the interactions of benzene, furan and thiophene with Lewis acids: the rotational spectrum of thiophene⋯HF journal July 1998
Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs journal June 2003
Rotational spectrum of thiophene···HCl Does thiophene act as an aromatic π-type electron donor or an n-type electron donor in hydrogen-bond formation? journal January 1998
The p K BHX Database: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal Chemists journal July 2009
Comparative Analysis of Twelve Genomes of Three Novel Group 2c and Group 2d Coronaviruses Reveals Unique Group and Subgroup Features journal November 2006
The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling journal January 2014
Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia journal November 2013
Mechanisms and enzymes involved in SARS coronavirus genome expression journal September 2003
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model journal September 2012
A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome journal May 2003
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group journal May 2013
ESPript/ENDscript: extracting and rendering sequence and 3D information from atomic structures of proteins journal July 2003
Coronaviruses post-SARS: update on replication and pathogenesis journal May 2009
Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation journal February 2014
Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26 journal September 2014
Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease journal January 2013
Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome journal May 2003
The rotational spectrum of thiophene⋯HBr and a comparison of the geometries of the complexes B⋯HX, where B is benzene, furan or thiophene and X is F, Cl or Br journal January 2004
ESPript: analysis of multiple sequence alignments in PostScript journal April 1999
The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” journal July 2013
Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease journal March 2006
Nidovirales: Evolving the largest RNA virus genome journal April 2006
Virus-encoded proteinases and proteolytic processing in the Nidovirales journal April 2000
Not much to malign multalin 4.0 journal March 1993
Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease. journal April 1967
Viral Replicase Gene Products Suffice for Coronavirus Discontinuous Transcription journal July 2001
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding journal November 2013