Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang; Chen, Lei; Gao, Feng; Joyce, M. Gordon; Ozorowski, Gabriel; Chuang, Gwo-Yu; Schramm, Chaim A.; Wiehe, Kevin; Alam, S. Munir; Bradley, Todd; Gladden, Morgan A.; Hwang, Kwan-Ki; Iyengar, Sheelah; Kumar, Amit; Lu, Xiaozhi; Luo, Kan; Mangiapani, Michael C.; Parks, Robert J.; Song, Hongshuo; Acharya, Priyamvada; Bailer, Robert T.; Cao, Allen; Druz, Aliaksandr; Georgiev, Ivelin S.; Kwon, Young D.; Louder, Mark K.; Zhang, Baoshan; Zheng, Anqi; Hill, Brenna J.; Kong, Rui; Soto, Cinque; Mullikin, James C.; Douek, Daniel C.; Montefiori, David C.; Moody, Michael A.; Shaw, George M.; Hahn, Beatrice H.; Kelsoe, Garnett; Hraber, Peter T.; Korber, Bette T.; Boyd, Scott D.; Fire, Andrew Z.; Kepler, Thomas B.; Shapiro, Lawrence; Ward, Andrew B.; Mascola, John R.; Liao, Hua-Xin; Kwong, Peter D.; Haynes, Barton F.

doi:10.1016/j.cell.2016.02.022

Title: Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Journal Article · Wed Apr 13 00:00:00 EDT 2016 · Cell

DOI:https://doi.org/10.1016/j.cell.2016.02.022· OSTI ID:1247358

Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang; Chen, Lei; Gao, Feng; Joyce, M. Gordon; Ozorowski, Gabriel; Chuang, Gwo-Yu; Schramm, Chaim A.; Wiehe, Kevin; Alam, S. Munir; Bradley, Todd; Gladden, Morgan A.; Hwang, Kwan-Ki; Iyengar, Sheelah; Kumar, Amit; Lu, Xiaozhi; Luo, Kan; Mangiapani, Michael C.; Parks, Robert J. more »

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: NIHNIAIDOTHER

OSTI ID:: 1247358

Journal Information:: Cell, Vol. 165, Issue (2) ; 04, 2016; ISSN 0092-8674

Country of Publication:: United States

Language:: ENGLISH

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Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques Gao, Nan; Gai, Yanxin; Meng, Lina Viruses, Vol. 12, Issue 2 https://doi.org/10.3390/v12020163	journal	January 2020
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Targeted selection of HIV-specific antibody mutations by engineering B cell maturation Saunders, Kevin O.; Wiehe, Kevin; Tian, Ming Science, Vol. 366, Issue 6470 https://doi.org/10.1126/science.aay7199	journal	December 2019
Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies Henderson, Rory; Watts, Brian E.; Ergin, Hieu N. Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-08415-7	journal	February 2019
Recent progress in broadly neutralizing antibodies to HIV Sok, Devin; Burton, Dennis R. Nature Immunology, Vol. 19, Issue 11 https://doi.org/10.1038/s41590-018-0235-7	journal	October 2018
Antibody responses to viral infections: a structural perspective across three different enveloped viruses Murin, Charles D.; Wilson, Ian A.; Ward, Andrew B. Nature Microbiology, Vol. 4, Issue 5 https://doi.org/10.1038/s41564-019-0392-y	journal	March 2019
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The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses Moysi, Eirini; Petrovas, Constantinos; Koup, Richard A. Retrovirology, Vol. 15, Issue 1 https://doi.org/10.1186/s12977-018-0437-y	journal	August 2018
HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth van Schooten, Jelle; van Gils, Marit J. Retrovirology, Vol. 15, Issue 1 https://doi.org/10.1186/s12977-018-0457-7	journal	November 2018
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