skip to main content

SciTech ConnectSciTech Connect

Title: Electron Bifurcation

Electron bifurcation is the recently recognized third mechanism of biological energy conservation. It simultaneously couples exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss. Little is known about the details of how electron bifurcating enzymes function, but specifics are beginning to emerge for several bifurcating enzymes. To date, those characterized contain a collection of redox cofactors including flavins and iron-sulfur clusters. Here we discuss the current understanding of bifurcating enzymes and the mechanistic features required to reversibly partition multiple electrons from a single redox site into exergonic and endergonic electron transfer paths.
; ; ; ;
Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 1367-5931
DOE Contract Number:
Resource Type:
Journal Article
Resource Relation:
Journal Name: Current Opinion in Chemical Biology; Journal Volume: 31; Related Information: Current Opinion in Chemical Biology
Research Org:
NREL (National Renewable Energy Laboratory (NREL), Golden, CO (United States))
Sponsoring Org:
USDOE Office of Energy Efficiency and Renewable Energy (EERE)
Country of Publication:
United States
37 INORGANIC, ORGANIC, PHYSICAL, AND ANAYLYTICAL CHEMISTRY electron bifurcation; endergonic; exergonic oxidation-reduction; redox reactions; electron transfer reactions