Butanol tolerance in microorganisms

Bramucci, Michael G.; Nagarajan, Vasantha

Title: Butanol tolerance in microorganisms

Patent · Tue Mar 01 00:00:00 EST 2016

OSTI ID:1241024

Bramucci, Michael G.; Nagarajan, Vasantha

Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products from a pyruvate utilizing pathway. Yeast host cells provided herein comprise reduced pyruvate decarboxylase activity and modified adenylate cyclase activity. In embodiments, yeast host cells provided herein comprise resistance to butanol and increased biomass production.

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Research Organization:: Butamax Advanced Biofuels LLC, Wilmington, DE (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AR0000006

Assignee:: Butamax Advanced Biofuels LLC (Wilmington, DE)

Patent Number(s):: 9,273,330

Application Number:: 14/045,506

OSTI ID:: 1241024

Resource Relation:: Patent File Date: 2013 Oct 03

Country of Publication:: United States

Language:: English

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Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis Anthony, Larry Cameron https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8465964 US Patent Document 8,465,964	patent	June 2013
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Yeast with increased butanol tolerance involving filamentous growth response Bramucci, Michael G.; Larossa, Robert A.; Singh, Manjari https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8557562 US Patent Document 8,557,562	patent	October 2013
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Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans Bramucci, Michael G.; Eliot, Andrew C.; Maggio-Hall, Lori Ann https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8691540 US Patent Document 8,691,540	patent	April 2014
Fermentive production of four carbon alcohols Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8735114 US Patent Document 8,735,114	patent	May 2014
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Fermentive production of four carbon alcohols Donaldson, Gail K.; Eliot, Andrew C.; Maggio-Hall, Lori Ann https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8828704 US Patent Document 8,828,704	patent	September 2014
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Ketol-acid reductoisomerase using NADH Li, Yougen; Liao, Der-Ing; Nelson, Mark J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8895307 US Patent Document 8,895,307	patent	November 2014
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Production of isobutanol by a microorganism with enhanced acetolactate synthase activity Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8945859 US Patent Document 8,945,859	patent	February 2015
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Fermentive production of four carbon alcohols Donaldson, Gail K.; Eliot, Andrew C.; Flint, Dennis https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8951774 US Patent Document 8,951,774	patent	February 2015
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Engineering Resistance to Aliphatic Alcohols Alsaker, Keith; Grenfell-Lee, Daniel; Hudson, Michael https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120058541 US Patent Application 13/214310; 20120058541	patent-application	March 2012
Fermentive Production of Four Carbon Alcohols Donaldson, Gail K.; Eliot, Andrew C.; Nagarajan, Vasantha https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120196341 US Patent Application 13/281872; 20120196341	patent-application	August 2012
Lignocellulosic Hydrolysates as Feedstocks for Isobutanol Fermentation Dobson, Ian David; Kruckeberg, Arthur Leo https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130035515 US Patent Application 13/525032; 20130035515	patent-application	February 2013
Acetate Supplementation of Medium for Butanologens Maggio-Hall, Lori Ann https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130252296 US Patent Application 13/833369; 20130252296	patent-application	September 2013
Host Cells and Methods for Production of Isobutanol Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140030782 US Patent Application 13/840649; 20140030782	patent-application	January 2014
Host Cells and Methods for Production of Isobutanol Anthony, Larry Cameron; He, Hongxian; Huang, Lixuan Lisa https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140030783 US Patent Application 13/840676; 20140030783	patent-application	January 2014
Activity of FE-S Cluster Requiring Proteins Flint, Dennis; Paul, Brian James; Ye, Rick W. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140038263 US Patent Application 13/837921; 20140038263	patent-application	February 2014
Dhad Variants for Butanol Production Maggio-Hall, Loriann Ann; Paul, Brian James; Rothman, Steven Cary https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140186910 US Patent Application 14/142,398; 2014/0186910 Al	patent-application	July 2014

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