Engineering antigen-specific immunological tolerance.
Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We present here recent developments in approaches, based on engineered peptides, proteins and biomaterials, that harness mechanisms of peripheral tolerance both prophylactically and therapeutically to induce antigenspecific immunological tolerance. These mechanisms are based on responses of B and T lymphocytes to other cells in their immune environment that result in cellular deletion or ignorance to particular antigens, or in development of active immune regulatory responses. Several of these approaches are moving toward clinical development, and some are already in early stages of clinical testing.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Science - Office of Basic Energy Sciences - Materials Sciences and Engineering Division
- DOE Contract Number:
- AC02-06CH11357
- OSTI ID:
- 1238793
- Journal Information:
- Current Opinion in Immunology, Vol. 35; ISSN 0952-7915
- Country of Publication:
- United States
- Language:
- English
Similar Records
Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase
Antigen-binding, idiotypic receptors from T lymphocytes: an analysis of their biochemistry, genetics, and use as immunogens to produce specific immune tolerance