Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers

Wang, Jun; Bonnesen, Peter V; Rangel, E.; Vallejo, E.; Sanchez-Castillo, Ariadna; Cleaves, II, H. James; Baddorf, Arthur P; Sumpter, Bobby G; Pan, Minghu; Maksymovych, Petro; Fuentes-Cabrera, Miguel A

doi:10.1038/srep18891

Title: Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers

Journal Article · Mon Jan 04 00:00:00 EST 2016 · Scientific Reports

DOI:https://doi.org/10.1038/srep18891· OSTI ID:1238003

Wang, Jun ^[1]; Bonnesen, Peter V ^[1]; Rangel, E. ^[2]; Vallejo, E. ^[2]; Sanchez-Castillo, Ariadna ^[2]; Cleaves, II, H. James ^[3]; Baddorf, Arthur P ^[1]; Sumpter, Bobby G ^[1]; Pan, Minghu ^[4]; Maksymovych, Petro ^[1]; Fuentes-Cabrera, Miguel A ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Universidad Autonoma del Estado de Hidalgo, Mexico; Autonomous Univ. of the State of Hidalgo (Mexico)
Tokyo Inst. of Technology (Japan); Inst. for Advanced Study, Princeton, NJ (United States); Blue Marble Space Inst. of Science, Washington, DC (United States); Georgia Inst. of Technology, Atlanta, GA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Huazhong Univ. of Science and Technology, Wuhan (China)

The self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N9-(2,3-dihydroxypropyl)adenine (DHPA), a plausibly prebiotic nucleoside analog of adenosine. It is found that DHPA molecules self-assemble into a hydrogen-bonded polymer that grows almost exclusively along the herringbone reconstruction pattern, has a two component sequence that is repeated over hundreds of nanometers, and is erasable with electron-induced excitation. Although the sequence is simple, more complicated ones are envisioned if two or more nucleoside types are combined. Because polymerization occurs on a substrate in a dry environment, the success of each combination can be gauged with high-resolution imaging and accurate modeling techniques. The resulting characteristics make nucleoside self-assembly on a substrate an attractive approach for designing sequence-controlled polymers. Moreover, by choosing plausibly prebiotic nucleosides, insights may be provided into how nature created the first sequence-controlled polymers capable of storing information. Such insights, in turn, can inspire new ways of synthesizing sequence-controlled polymers.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Oak Ridge Leadership Computing Facility (OLCF); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1238003

Journal Information:: Scientific Reports, Vol. 6; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 5 works

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