Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor

Maize, Kimberly M.; Kurbanov, Elbek K.; Johnson, Rodney L.; Amin, Elizabeth Ambrose; Finzel, Barry C.

doi:10.1016/j.febslet.2015.11.005

Title: Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor

Journal Article · Wed Nov 11 00:00:00 EST 2015 · FEBS Letters

DOI:https://doi.org/10.1016/j.febslet.2015.11.005· OSTI ID:1237749

Maize, Kimberly M. ^[1]; Kurbanov, Elbek K. ^[1]; Johnson, Rodney L. ^[1]; Amin, Elizabeth Ambrose ^[1]; Finzel, Barry C. ^[1]

Univ. of Minnesota, Minneapolis, MN (United States)

The Bacillus anthracis lethal factor (LF) is one component of a tripartite exotoxin partly responsible for persistent anthrax cytotoxicity after initial bacterial infection. Inhibitors of the zinc metalloproteinase have been investigated as potential therapeutic agents, but LF is a challenging target because inhibitors lack sufficient selectivity or possess poor pharmaceutical properties. Furthermore, these structural studies reveal an alternate conformation of the enzyme, induced upon binding of specific inhibitors, that opens a previously unobserved deep pocket termed S1'* which might afford new opportunities to design selective inhibitors that target this subsite.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Institutes of Health (NIH)

Grant/Contract Number:: R01 AI083234

OSTI ID:: 1237749

Journal Information:: FEBS Letters, Vol. 589, Issue 24PartB; ISSN 0014-5793

Publisher:: Federation of European Biochemical SocietiesCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 4 works

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59 BASIC BIOLOGICAL SCIENCES
LF
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Ligand-induced
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Title: Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor

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