A mutational signature in gastric cancer suggests therapeutic strategies

Alexandrov, Ludmil B.; Nik-Zainal, Serena; Siu, Hoi Cheong; Leung, Suet Yi; Stratton, Michael R.

doi:10.1038/ncomms9683

Title: A mutational signature in gastric cancer suggests therapeutic strategies

Journal Article · Thu Oct 29 00:00:00 EDT 2015 · Nature Communications

DOI:https://doi.org/10.1038/ncomms9683· OSTI ID:1236756

^[1]; Nik-Zainal, Serena ^[2]; Siu, Hoi Cheong ^[3]; Leung, Suet Yi ^[3]; Stratton, Michael R. ^[4]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Wellcome Trust Sanger Institute, Hinxton (United Kingdom)
Wellcome Trust Sanger Institute, Hinxton (United Kingdom); Addenbrooke's Hospital National Health Service (NHS) Trust, Cambridge (United Kingdom)
The Univ. of Hong Kong, Queen Mary Hospital, Pokfulam (Hong Kong)
Wellcome Trust Sanger Institute, Hinxton (United Kingdom)

Targeting defects in the DNA repair machinery of neoplastic cells, for example, those due to inactivating BRCA1 and/or BRCA2 mutations, has been used for developing new therapies in certain types of breast, ovarian and pancreatic cancers. Recently, a mutational signature was associated with failure of double-strand DNA break repair by homologous recombination based on its high mutational burden in samples harbouring BRCA1 or BRCA2 mutations. In pancreatic cancer, all responders to platinum therapy exhibit this mutational signature including a sample that lacked any defects in BRCA1 or BRCA2. Here, we examine 10,250 cancer genomes across 36 types of cancer and demonstrate that, in addition to breast, ovarian and pancreatic cancers, gastric cancer is another cancer type that exhibits this mutational signature. Furthermore, our results suggest that 7–12% of gastric cancers have defective double-strand DNA break repair by homologous recombination and may benefit from either platinum therapy or PARP inhibitors.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1236756

Report Number(s):: LA-UR-15-24068; ncomms9683

Journal Information:: Nature Communications, Vol. 6; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 123 works

Citation information provided by
Web of Science

References (37)

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families Ford, D.; Easton, D. F.; Stratton, M. The American Journal of Human Genetics, Vol. 62, Issue 3 https://doi.org/10.1086/301749	journal	March 1998
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 King, M. -C. Science, Vol. 302, Issue 5645 https://doi.org/10.1126/science.1088759	journal	October 2003
Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer Risch, Harvey A.; McLaughlin, John R.; Cole, David E. C. The American Journal of Human Genetics, Vol. 68, Issue 3 https://doi.org/10.1086/318787	journal	March 2001
Role of BRCA1 and BRCA2 mutations in pancreatic cancer Greer, J. B.; Whitcomb, D. C. Gut, Vol. 56, Issue 5 https://doi.org/10.1136/gut.2006.101220	journal	May 2007
Somatic mutations in the BRCA1 gene in sporadic ovarian tumours Merajver, Sofia D.; Pham, Trinh M.; Caduff, Rosemarie F. Nature Genetics, Vol. 9, Issue 4 https://doi.org/10.1038/ng0495-439	journal	April 1995
Mutation analysis in the BRCA2 gene in primary breast cancers Miki, Yoshio; Katagiri, Toyomasa; Kasumi, Fujio Nature Genetics, Vol. 13, Issue 2 https://doi.org/10.1038/ng0696-245	journal	June 1996
Sensing and repairing DNA double-strand breaks Jackson, S. P. Carcinogenesis, Vol. 23, Issue 5 https://doi.org/10.1093/carcin/23.5.687	journal	May 2002
Mutational Processes Molding the Genomes of 21 Breast Cancers Nik-Zainal, Serena; Alexandrov, Ludmil B.; Wedge, David C. Cell, Vol. 149, Issue 5 https://doi.org/10.1016/j.cell.2012.04.024	journal	May 2012
Spectrum of Mutations in BRCA1, BRCA2, CHEK2, and TP53 in Families at High Risk of Breast Cancer Walsh, Tom; Casadei, Silvia; Coats, Kathryn Hale JAMA, Vol. 295, Issue 12 https://doi.org/10.1001/jama.295.12.1379	journal	March 2006
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs Rottenberg, S.; Jaspers, J. E.; Kersbergen, A. Proceedings of the National Academy of Sciences, Vol. 105, Issue 44 https://doi.org/10.1073/pnas.0806092105	journal	October 2008
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Farmer, Hannah; McCabe, Nuala; Lord, Christopher J. Nature, Vol. 434, Issue 7035 https://doi.org/10.1038/nature03445	journal	April 2005
Signatures of mutational processes in human cancer Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. Nature, Vol. 500, Issue 7463 https://doi.org/10.1038/nature12477	journal	August 2013
Mutational signatures: the patterns of somatic mutations hidden in cancer genomes Alexandrov, Ludmil B.; Stratton, Michael R. Current Opinion in Genetics & Development, Vol. 24 https://doi.org/10.1016/j.gde.2013.11.014	journal	February 2014
Mechanisms underlying mutational signatures in human cancers Helleday, Thomas; Eshtad, Saeed; Nik-Zainal, Serena Nature Reviews Genetics, Vol. 15, Issue 9 https://doi.org/10.1038/nrg3729	journal	July 2014
Deciphering Signatures of Mutational Processes Operative in Human Cancer Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. Cell Reports, Vol. 3, Issue 1 https://doi.org/10.1016/j.celrep.2012.12.008	journal	January 2013
Whole genomes redefine the mutational landscape of pancreatic cancer Waddell, Nicola; Pajic, Marina; Patch, Ann-Marie Nature, Vol. 518, Issue 7540 https://doi.org/10.1038/nature14169	journal	February 2015
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer Wang, Kai; Yuen, Siu Tsan; Xu, Jiangchun Nature Genetics, Vol. 46, Issue 6 https://doi.org/10.1038/ng.2983	journal	May 2014
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes Zang, Zhi Jiang; Cutcutache, Ioana; Poon, Song Ling Nature Genetics, Vol. 44, Issue 5 https://doi.org/10.1038/ng.2246	journal	April 2012
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer Wang, Kai; Kan, Junsuo; Yuen, Siu Tsan Nature Genetics, Vol. 43, Issue 12 https://doi.org/10.1038/ng.982	journal	October 2011
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Ferlay, Jacques; Shin, Hai-Rim; Bray, Freddie International Journal of Cancer, Vol. 127, Issue 12 https://doi.org/10.1002/ijc.25516	journal	June 2010
dbSNP: the NCBI database of genetic variation Sherry, S. T. Nucleic Acids Research, Vol. 29, Issue 1 https://doi.org/10.1093/nar/29.1.308	journal	January 2001
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants Fu, Wenqing; O’Connor, Timothy D.; Jun, Goo Nature, Vol. 493, Issue 7431 https://doi.org/10.1038/nature11690	journal	November 2012
The UCSC Genome Browser database: extensions and updates 2011 Dreszer, T. R.; Karolchik, D.; Zweig, A. S. Nucleic Acids Research, Vol. 40, Issue D1 https://doi.org/10.1093/nar/gkr1055	journal	November 2011
Genome sequencing of normal cells reveals developmental lineages and mutational processes Behjati, Sam; Huch, Meritxell; van Boxtel, Ruben Nature, Vol. 513, Issue 7518 https://doi.org/10.1038/nature13448	journal	June 2014
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma Bolli, Niccolo; Avet-Loiseau, Hervé; Wedge, David C. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms3997	journal	January 2014
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer Ju, Young Seok; Alexandrov, Ludmil B.; Gerstung, Moritz eLife, Vol. 3 https://doi.org/10.7554/eLife.02935	journal	October 2014
Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage Murchison, E. P.; Wedge, D. C.; Alexandrov, L. B. Science, Vol. 343, Issue 6169 https://doi.org/10.1126/science.1247167	journal	January 2014
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer Nik-Zainal, Serena; Wedge, David C.; Alexandrov, Ludmil B. Nature Genetics, Vol. 46, Issue 5 https://doi.org/10.1038/ng.2955	journal	April 2014
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing Gerlinger, Marco; Horswell, Stuart; Larkin, James Nature Genetics, Vol. 46, Issue 3 https://doi.org/10.1038/ng.2891	journal	February 2014
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma. Bolli, Niccolo; Avet-Loiseau, Hervé; Wedge, David C. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.33452	text	January 2014
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer. Nik-Zainal, Serena; Wedge, David C.; Alexandrov, Ludmil B. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.42271	text	January 2014
Deciphering signatures of mutational processes operative in human cancer. Alexandrov, Ludmil B.; Nik-Zainal Abidin, Serena; Wedge, David C. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.60112	text	January 2013
Comprehensive molecular characterization of gastric adenocarcinoma Reanne, Bowlby,; Amaro, Taylor-Weiner,; Andy, Chu, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/eyft-ty56	text	January 2014
An integrated map of genetic variation from 1,092 human genomes Yun, Li, The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/rsw4-ne53	text	January 2012
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Ju, Young Seok; Alexandrov, Ludmil B.; Gerstung, Moritz Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.31876	text	January 2014
Signatures of mutational processes in human cancer. Alexandrov, Ludmil B.; Nik-Zainal Abidin, Serena; Wedge, David C. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.31889	text	January 2013
Recurrent Somatic Mutations in Human Gastric Cancers Identified by Whole Exome Sequencing Shimizu, Takahiro; Marusawa, Hiroyuki; Chiba, Tsutomu Gastroenterology, Vol. 143, Issue 5 https://doi.org/10.1053/j.gastro.2012.09.027	journal	November 2012

Cited By (45)

Tumor mutation burden and recurrent tumors in hereditary lung cancer Hsu, Yi‐Chiung; Chang, Ya‐Hsuan; Chang, Gee‐Chen Cancer Medicine, Vol. 8, Issue 5 https://doi.org/10.1002/cam4.2120	journal	April 2019
Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas: Mutational signature associated with MUTYH deficiency in cancers Pilati, Camilla; Shinde, Jayendra; Alexandrov, Ludmil B. The Journal of Pathology, Vol. 242, Issue 1 https://doi.org/10.1002/path.4880	journal	March 2017
Personalised Treatment in Gastric Cancer: Myth or Reality? Tarazona, Noelia; Gambardella, Valentina; Huerta, Marisol Current Oncology Reports, Vol. 18, Issue 7 https://doi.org/10.1007/s11912-016-0525-x	journal	May 2016
Precision oncology in the age of integrative genomics Kumar-Sinha, Chandan; Chinnaiyan, Arul M. Nature Biotechnology, Vol. 36, Issue 1 https://doi.org/10.1038/nbt.4017	journal	January 2018
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance Secrier, Maria; Li, Xiaodun; de Silva, Nadeera Nature Genetics, Vol. 48, Issue 10 https://doi.org/10.1038/ng.3659	journal	September 2016
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures Davies, Helen; Glodzik, Dominik; Morganella, Sandro Nature Medicine, Vol. 23, Issue 4 https://doi.org/10.1038/nm.4292	journal	March 2017
BRCAness revisited Lord, Christopher J.; Ashworth, Alan Nature Reviews Cancer, Vol. 16, Issue 2 https://doi.org/10.1038/nrc.2015.21	journal	January 2016
Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes Riaz, Nadeem; Blecua, Pedro; Lim, Raymond S. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00921-w	journal	October 2017
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors Adalsteinsson, Viktor A.; Ha, Gavin; Freeman, Samuel S. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00965-y	journal	November 2017
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers Guo, Yu Amanda; Chang, Mei Mei; Huang, Weitai Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-03828-2	journal	April 2018
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer Ishaque, Naveed; Abba, Mohammed L.; Hauser, Christine Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-07041-z	journal	November 2018
The genetic landscape of 5T models for multiple myeloma Maes, Ken; Boeckx, Bram; Vlummens, Philip Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-33396-w	journal	October 2018
Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer Lin, Peng-Chan; Yeh, Yu-Min; Wu, Pei-Ying Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-40571-0	journal	March 2019
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes Pleasance, Erin; Titmuss, Emma; Williamson, Laura Nature Cancer, Vol. 1, Issue 4 https://doi.org/10.1038/s43018-020-0050-6	journal	April 2020
Targeting deficient DNA damage repair in gastric cancer Young, Kate; Starling, Naureen; Cunningham, David Expert Opinion on Pharmacotherapy, Vol. 17, Issue 13 https://doi.org/10.1080/14656566.2016.1217992	journal	August 2016
Computational approaches for discovery of mutational signatures in cancer Baez-Ortega, Adrian; Gori, Kevin Briefings in Bioinformatics, Vol. 20, Issue 1 https://doi.org/10.1093/bib/bbx082	journal	July 2017
Understanding mutagenesis through delineation of mutational signatures in human cancer Petljak, Mia; Alexandrov, Ludmil B. Carcinogenesis, Vol. 37, Issue 6 https://doi.org/10.1093/carcin/bgw055	journal	May 2016
Exploring background mutational processes to decipher cancer genetic heterogeneity Goncearenco, Alexander; Rager, Stephanie L.; Li, Minghui Nucleic Acids Research, Vol. 45, Issue W1 https://doi.org/10.1093/nar/gkx367	journal	May 2017
SigLASSO: a LASSO approach jointly optimizing sampling likelihood and cancer mutation signatures Li, Shantao; Crawford, Forrest W.; Gerstein, Mark B. Nature Communications https://doi.org/10.1101/366740	posted_content	May 2018
Genomic aberration based molecular signatures efficiently characterize homologous recombination deficiency in prostate cancer Sztupinszki, Zsofia; Diossy, Miklos; Krzystanek, Marcin BioRxiv https://doi.org/10.1101/681114	posted_content	June 2019
Mutational signatures associated with tobacco smoking in human cancer Alexandrov, L. B.; Ju, Y. S.; Haase, K. Science, Vol. 354, Issue 6312 https://doi.org/10.1126/science.aag0299	journal	November 2016
Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas Lin, De-Chen; Dinh, Huy Q.; Xie, Jian-Jun Gut, Vol. 67, Issue 10 https://doi.org/10.1136/gutjnl-2017-314607	journal	August 2017
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma Turkington, Richard C.; Knight, Laura A.; Blayney, Jaine K. Gut, Vol. 68, Issue 11 https://doi.org/10.1136/gutjnl-2018-317624	journal	March 2019
Portrait of a cancer: mutational signature analyses for cancer diagnostics Van Hoeck, Arne; Tjoonk, Niels H.; van Boxtel, Ruben BMC Cancer, Vol. 19, Issue 1 https://doi.org/10.1186/s12885-019-5677-2	journal	May 2019
Actionable gene-based classification toward precision medicine in gastric cancer Ichikawa, Hiroshi; Nagahashi, Masayuki; Shimada, Yoshifumi Genome Medicine, Vol. 9, Issue 1 https://doi.org/10.1186/s13073-017-0484-3	journal	October 2017
FIREVAT: finding reliable variants without artifacts in human cancer samples using etiologically relevant mutational signatures Kim, Hyunbin; Lee, Andy Jinseok; Lee, Jongkeun Genome Medicine, Vol. 11, Issue 1 https://doi.org/10.1186/s13073-019-0695-x	journal	December 2019
Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model Paviolo, Natalia Soledad; Vega, María Belén de la; Pansa, María Florencia Genetics and Molecular Biology, Vol. 43, Issue 1 suppl 1 https://doi.org/10.1590/1678-4685-gmb-2019-0070	journal	January 2020
Mutational signatures associated with tobacco smoking in human cancer Alexandrov, Ludmil B.; Ju, Young Seok; Haase, Kerstin bioRxiv https://doi.org/10.1101/051417	posted_content	May 2016
Computational approaches for discovery of mutational signatures in cancer Baez-Ortega, Adrian; Gori, Kevin https://doi.org/10.1101/154716	posted_content	June 2017
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. Davies, Helen; Glodzik, Dominik; Morganella, Sandro Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.61944	text	January 2017
Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance Secrier, Maria; Li, Xiaodun; De, Silva Nadeera Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.818	text	January 2016
Computational approaches for discovery of mutational signatures in cancer. Baez-Ortega, Adrian; Gori, Kevin Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.11113	text	January 2019
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma. Turkington, Richard C.; Knight, Laura A.; Blayney, Jaine K. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.44131	text	January 2019
Base changes in tumour DNA have the power to reveal the causes and evolution of cancer Hollstein, M.; Alexandrov, L. B.; Wild, C. P. Oncogene, Vol. 36, Issue 2 https://doi.org/10.1038/onc.2016.192	journal	June 2016
A proteogenomic approach for protein-level evidence of genomic variants in cancer cells Yeom, Jeonghun; Kabir, Mohammad Humayun; Lim, Byungho Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep35305	journal	October 2016
KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer Zhang, Shu; Huang, Fang; Wang, Yan Disease Markers, Vol. 2016 https://doi.org/10.1155/2016/7484516	journal	January 2016
The evolving immunotherapeutic landscape in advanced oesophagogastric cancer Flynn, Michael; Young, Kate; Cunningham, David Therapeutic Advances in Medical Oncology, Vol. 10 https://doi.org/10.1177/1758835918786228	journal	January 2018
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. Stammnitz, Maximilian R.; Coorens, Tim HH; Gori, Kevin C. Elsevier BV https://doi.org/10.17863/cam.21016	journalarticle	January 2018
Platelet distribution width correlates with prognosis of gastric cancer Zhang, Xin; Cui, Ming-Ming; Fu, Shuang Oncotarget, Vol. 8, Issue 12 https://doi.org/10.18632/oncotarget.15561	journal	February 2017
Comprehensive analysis of a novel four-lncRNA signature as a prognostic biomarker for human gastric cancer Miao, Yan; Sui, Jing; Xu, Si-Yi Oncotarget, Vol. 8, Issue 43 https://doi.org/10.18632/oncotarget.20496	journal	August 2017
The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles Volinia, Stefano; Druck, Teresa; Paisie, Carolyn A. Oncotarget, Vol. 8, Issue 60 https://doi.org/10.18632/oncotarget.22321	journal	November 2017
Somatic genome alterations in relation to age in lung squamous cell carcinoma Meucci, Stefano; Keilholz, Ulrich; Heim, Daniel Oncotarget, Vol. 9, Issue 63 https://doi.org/10.18632/oncotarget.25848	journal	August 2018
Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer Wu, Han; Xian, Yun; Zhang, Shu OncoTargets and Therapy, Vol. Volume 9 https://doi.org/10.2147/ott.s105787	journal	September 2016
The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents Kim, Geon; Kim, Jisu; Han, Su‑Young Oncology Letters https://doi.org/10.3892/ol.2019.10169	journal	March 2019
Analysis of microRNA expression profiles reveals a 5‑microRNA prognostic signature for predicting overall survival time in patients with gastric adenocarcinoma Zhao, Ruihong; Zhao, Lei; Xu, Xu Oncology Reports https://doi.org/10.3892/or.2019.7048	journal	March 2019

Similar Records

Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?

Journal Article · Sun Dec 15 00:00:00 EST 2019 · Medical Oncology (Online) · OSTI ID:1236756

Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability

Journal Article · Mon Feb 01 00:00:00 EST 2016 · Molecular Cell · OSTI ID:1236756

Trego, Kelly S.; Groesser, Torsten; Davalos, Albert R.; +13 more

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Journal Article · Mon May 02 00:00:00 EDT 2016 · Nature (London) · OSTI ID:1236756

Nik-Zainal, Serena; Davies, Helen; Staaf, Johan; +85 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
biological sciences
cancer
genetics
medical research

Title: A mutational signature in gastric cancer suggests therapeutic strategies

Citation Formats

References (37)

Cited By (45)

Similar Records

Related Subjects