Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission

Sanborn, Keri B.; Somasundaran, Mohan; Luzuriaga, Katherine; Leitner, Thomas K.

doi:10.1186/s12977-015-0222-0

Title: Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission

Journal Article · Mon Nov 16 00:00:00 EST 2015 · Retrovirology

DOI:https://doi.org/10.1186/s12977-015-0222-0· OSTI ID:1236028

Sanborn, Keri B. ^[1]; Somasundaran, Mohan ^[1]; Luzuriaga, Katherine ^[1]; Leitner, Thomas K. ^[2]

Univ. of Massachusetts, Worcester, MA (United States). Dept. of Chemistry
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Some previous studies have demonstrated that single HIV-1 genotypes are commonly transmitted from mother to child, but such analyses primarily used single samples from mother and child. It is possible that in a single sample, obtained early after infection, only the most replication competent virus is detected even when other forms may have been transmitted. Such forms may have advantages later in infection, and may thus be detected in follow-up samples. Furthermore, because HIV-1 frequently recombines, phylogenetic analyses that ignore recombination may miss transmission of multiple forms if they recombine after transmission. Moreover, recombination may facilitate adaptation, thus providing an advantage in establishing infection. The effect of recombination on viral evolution in HIV-1 infected children has not been well defined.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: R01AI097265; F32-AI108414; AC52-06NA25396

OSTI ID:: 1236028

Report Number(s):: LA-UR-15-26872; PII: 222

Journal Information:: Retrovirology, Vol. 12, Issue 1; ISSN 1742-4690

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 2 works

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59 BASIC BIOLOGICAL SCIENCES
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MOESM3 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590_d1.v1 The current record is supplemented by this dataset	dataset	November 2015
Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590.v1 The current record is supplemented by this dataset	dataset	November 2015
MOESM4 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590_d4.v1 The current record is supplemented by this dataset	dataset	November 2015
Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590 The current record is supplemented by this dataset	dataset	November 2015
MOESM2 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590_d3.v1 The current record is supplemented by this dataset	dataset	November 2015
MOESM2 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission https://doi.org/10.6084/m9.figshare.c.3633590_d3 The current record is supplemented by this dataset	dataset	November 2015
MOESM1 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590_d2 The current record is supplemented by this figure	figure	November 2015
MOESM3 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590_d1 The current record is supplemented by this other	other	November 2015
MOESM4 of Recombination elevates the effective evolutionary rate and facilitates the establishment of HIV-1 infection in infants after mother-to-child transmission Sanborn, Keri; Somasundaran, Mohan; Luzuriaga, Katherine https://doi.org/10.6084/m9.figshare.c.3633590_d4 The current record is supplemented by this dataset	dataset	November 2015