Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Schulze, Kornelius; Imbeaud, Sandrine; Letouzé, Eric; Alexandrov, Ludmil B.; Calderaro, Julien; Rebouissou, Sandra; Couchy, Gabrielle; Meiller, Clément; Shinde, Jayendra; Soysouvanh, Frederic; Calatayud, Anna-Line; Pinyol, Roser; Pelletier, Laura; Balabaud, Charles; Laurent, Alexis; Blanc, Jean-Frederic; Mazzaferro, Vincenzo; Calvo, Fabien; Villanueva, Augusto; Nault, Jean-Charles; Bioulac-Sage, Paulette; Stratton, Michael R.; Llovet, Josep M.; Zucman-Rossi, Jessica

doi:10.1038/ng.3252

Title: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Journal Article · Mon Mar 30 00:00:00 EDT 2015 · Nature Genetics

DOI:https://doi.org/10.1038/ng.3252· OSTI ID:1235730

Schulze, Kornelius ^[1]; Imbeaud, Sandrine ^[1]; Letouzé, Eric ^[1]; Alexandrov, Ludmil B. ^[2]; Calderaro, Julien ^[3]; Rebouissou, Sandra ^[1]; Couchy, Gabrielle ^[1]; Meiller, Clément ^[1]; Shinde, Jayendra ^[1]; Soysouvanh, Frederic ^[1]; Calatayud, Anna-Line ^[1]; Pinyol, Roser ^[4]; Pelletier, Laura ^[1]; Balabaud, Charles ^[5]; Laurent, Alexis ^[6]; Blanc, Jean-Frederic ^[7]; Mazzaferro, Vincenzo ^[8]; Calvo, Fabien ^[1]; Villanueva, Augusto ^[9]; Nault, Jean-Charles ^[10] more »

INSERM, Paris (France); Paris Descartes Univ., (France); Paris 13 Univ. (France); Paris Diderot Univ. (France)
Wellcome Trust Sanger Inst., Hinxton (United Kingdom); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
INSERM, Paris (France); Paris Descartes Univ., (France); Paris 13 Univ. (France); Paris Diderot Univ. (France); Public Assistance Hospital of Paris (France)
Hepatocellular Carcinoma Translational Research Laboratory, Barcelona (Spain)
INSERM, Bordeaux (France)
Public Assistance Hospital of Paris (France); INSERM, Creteil (France)
INSERM, Bordeaux (France); Bordeaux Univ. Hospital (France)
Fondazione Inst., Milan (Italy)
Hepatocellular Carcinoma Translational Research Laboratory, Barcelona (Spain); Mount Sinai School of Medicine, New York, NY (United States)
INSERM, Paris (France); Paris Descartes Univ., (France); Paris 13 Univ. (France); Paris Diderot Univ. (France); Univ. Hospital of Paris (France)
Wellcome Trust Sanger Inst., Hinxton (United Kingdom)
Hepatocellular Carcinoma Translational Research Laboratory, Barcelona (Spain); Mount Sinai School of Medicine, New York, NY (United States); Catalan Inst. for Research Studies, Barcelona (Spain)

Our genomic analyses promise to improve tumor characterization to optimize personalized treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1. We identified 161 putative driver genes associated with 11 recurrently altered pathways. Associations of mutations defined 3 groups of genes related to risk factors and centered on CTNNB1 (alcohol), TP53 (hepatitis B virus, HBV) and AXIN1. These analyses according to tumor stage progression identified TERT promoter mutation as an early event, whereasFGF3, FGF4, FGF19 or CCND1 amplification and TP53 and CDKN2A alterations appeared at more advanced stages in aggressive tumors. In 28% of the tumors, we identified genetic alterations potentially targetable by US Food and Drug Administration (FDA)–approved drugs. Finally, we identified risk factor–specific mutational signatures and defined the extensive landscape of altered genes and pathways in HCC, which will be useful to design clinical trials for targeted therapy.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1235730

Report Number(s):: LA-UR-14-28199; ng.3252

Journal Information:: Nature Genetics, Vol. 47, Issue 5; ISSN 1061-4036

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 1089 works

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References (48)

Hepatocellular carcinoma Forner, Alejandro; Llovet, Josep M.; Bruix, Jordi The Lancet, Vol. 379, Issue 9822 https://doi.org/10.1016/S0140-6736(11)61347-0	journal	March 2012
Hepatocellular Carcinoma El-Serag, Hashem B. New England Journal of Medicine, Vol. 365, Issue 12 https://doi.org/10.1056/NEJMra1001683	journal	September 2011
Pathologic diagnosis of early hepatocellular carcinoma: A report of the international consensus group for hepatocellular neoplasia Hepatology, Vol. 49, Issue 2, p. 658-664 https://doi.org/10.1002/hep.22709	journal	October 2008
Genotype–phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC Zucman-Rossi, Jessica; Jeannot, Emmanuelle; Van Nhieu, Jeanne Tran Hepatology, Vol. 43, Issue 3 https://doi.org/10.1002/hep.21068	journal	January 2006
Hepatocellular Benign Tumors—From Molecular Classification to Personalized Clinical Care Nault, Jean–Charles; Bioulac–Sage, Paulette; Zucman–Rossi, Jessica Gastroenterology, Vol. 144, Issue 5 https://doi.org/10.1053/j.gastro.2013.02.032	journal	May 2013
Genomic Profiling of Hepatocellular Adenomas Reveals Recurrent FRK-Activating Mutations and the Mechanisms of Malignant Transformation Pilati, Camilla; Letouzé, Eric; Nault, Jean-Charles Cancer Cell, Vol. 25, Issue 4 https://doi.org/10.1016/j.ccr.2014.03.005	journal	April 2014
Hepatocellular carcinoma: clinical frontiers and perspectives Bruix, Jordi; Gores, Gregory J.; Mazzaferro, Vincenzo Gut, Vol. 63, Issue 5 https://doi.org/10.1136/gutjnl-2013-306627	journal	February 2014
Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis C Bedossa, P. Hepatology, Vol. 20, Issue 1 https://doi.org/10.1002/hep.1840200104	journal	July 1994
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma Guichard, Cécile; Amaddeo, Giuliana; Imbeaud, Sandrine Nature Genetics, Vol. 44, Issue 6 https://doi.org/10.1038/ng.2256	journal	May 2012
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators Fujimoto, Akihiro; Totoki, Yasushi; Abe, Tetsuo Nature Genetics, Vol. 44, Issue 7 https://doi.org/10.1038/ng.2291	journal	May 2012
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma Kan, Z.; Zheng, H.; Liu, X. Genome Research, Vol. 23, Issue 9 https://doi.org/10.1101/gr.154492.113	journal	June 2013
Signatures of mutational processes in human cancer Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. Nature, Vol. 500, Issue 7463 https://doi.org/10.1038/nature12477	journal	August 2013
Mechanisms underlying mutational signatures in human cancers Helleday, Thomas; Eshtad, Saeed; Nik-Zainal, Serena Nature Reviews Genetics, Vol. 15, Issue 9 https://doi.org/10.1038/nrg3729	journal	July 2014
Deciphering Signatures of Mutational Processes Operative in Human Cancer Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. Cell Reports, Vol. 3, Issue 1 https://doi.org/10.1016/j.celrep.2012.12.008	journal	January 2013
Mutational signatures: the patterns of somatic mutations hidden in cancer genomes Alexandrov, Ludmil B.; Stratton, Michael R. Current Opinion in Genetics & Development, Vol. 24 https://doi.org/10.1016/j.gde.2013.11.014	journal	February 2014
Mutational hot spot in the p53 gene in human hepatocellular carcinomas Hsu, I. C.; Metcalf, R. A.; Sun, T. Nature, Vol. 350, Issue 6317 https://doi.org/10.1038/350427a0	journal	April 1991
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa Bressac, Brigitte; Kew, Michael; Wands, Jack Nature, Vol. 350, Issue 6317 https://doi.org/10.1038/350429a0	journal	April 1991
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes Totoki, Yasushi; Tatsuno, Kenji; Covington, Kyle R. Nature Genetics, Vol. 46, Issue 12 https://doi.org/10.1038/ng.3126	journal	November 2014
Mutational heterogeneity in cancer and the search for new cancer-associated genes Lawrence, Michael S.; Stojanov, Petar; Polak, Paz Nature, Vol. 499, Issue 7457 https://doi.org/10.1038/nature12213	journal	June 2013
Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening Sawey, Eric T.; Chanrion, Maia; Cai, Chunlin Cancer Cell, Vol. 19, Issue 3 https://doi.org/10.1016/j.ccr.2011.01.040	journal	March 2011
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions Nault, Jean Charles; Mallet, Maxime; Pilati, Camilla Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms3218	journal	July 2013
Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma Totoki, Yasushi; Yoshida, Akihiko; Hosoda, Fumie Genome Research, Vol. 24, Issue 9 https://doi.org/10.1101/gr.160598.113	journal	July 2014
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Barretina, Jordi; Caponigro, Giordano; Stransky, Nicolas Nature, Vol. 483, Issue 7391 https://doi.org/10.1038/nature11003	journal	March 2012
Systematic identification of genomic markers of drug sensitivity in cancer cells Garnett, Mathew J.; Edelman, Elena J.; Heidorn, Sonja J. Nature, Vol. 483, Issue 7391 https://doi.org/10.1038/nature11005	journal	March 2012
Rapid Polyubiquitination and Proteasomal Degradation of a Mutant Form of NAD(P)H:Quinone Oxidoreductase 1 Siegel, David; Anwar, Adil; Winski, Shannon L. Molecular Pharmacology, Vol. 59, Issue 2 https://doi.org/10.1124/mol.59.2.263	journal	February 2001
Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification Ahn, Sung‐Min; Jang, Se Jin; Shim, Ju Hyun Hepatology, Vol. 60, Issue 6 https://doi.org/10.1002/hep.27198	journal	September 2014
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma Wang, Kai; Lim, Ho Yeong; Shi, Stephanie Hepatology, Vol. 58, Issue 2 https://doi.org/10.1002/hep.26402	journal	July 2013
Expression of Fibroblast Growth Factor 19 Is Associated with Recurrence and Poor Prognosis of Hepatocellular Carcinoma Hyeon, Jiyeon; Ahn, Soomin; Lee, Jae Jun Digestive Diseases and Sciences, Vol. 58, Issue 7 https://doi.org/10.1007/s10620-013-2609-x	journal	March 2013
Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma Miura, Seiki; Mitsuhashi, Noboru; Shimizu, Hiroaki BMC Cancer, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2407-12-56	journal	February 2012
qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles Song, Sarah; Nones, Katia; Miller, David PLoS ONE, Vol. 7, Issue 9 https://doi.org/10.1371/journal.pone.0045835	journal	September 2012
A simple salting out procedure for extracting DNA from human nucleated cells Miller, S. A.; Dykes, D. D.; Polesky, H. F. Nucleic Acids Research, Vol. 16, Issue 3 https://doi.org/10.1093/nar/16.3.1215	journal	January 1988
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing Gnirke, Andreas; Melnikov, Alexandre; Maguire, Jared Nature Biotechnology, Vol. 27, Issue 2 https://doi.org/10.1038/nbt.1523	journal	February 2009
A method and server for predicting damaging missense mutations Adzhubei, Ivan A.; Schmidt, Steffen; Peshkin, Leonid Nature Methods, Vol. 7, Issue 4 https://doi.org/10.1038/nmeth0410-248	journal	April 2010
An interior algorithm for nonlinear optimization that combines line search and trust region steps Waltz, R. A.; Morales, J. L.; Nocedal, J. Mathematical Programming, Vol. 107, Issue 3 https://doi.org/10.1007/s10107-004-0560-5	journal	November 2005
Circular binary segmentation for the analysis of array-based DNA copy number data Olshen, A. B.; Venkatraman, E. S.; Lucito, R. Biostatistics, Vol. 5, Issue 4 https://doi.org/10.1093/biostatistics/kxh008	journal	October 2004
NormaCurve: A SuperCurve-Based Method That Simultaneously Quantifies and Normalizes Reverse Phase Protein Array Data Troncale, Sylvie; Barbet, Aurélie; Coulibaly, Lamine PLoS ONE, Vol. 7, Issue 6 https://doi.org/10.1371/journal.pone.0038686	journal	June 2012
OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine López-Cortés, Andrés; Paz-y-Miño, César; Guerrero, Santiago Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-62279-2	journal	March 2020
Signatures of mutational processes in human cancer. Alexandrov, Ludmil B.; Nik-Zainal Abidin, Serena; Wedge, David C. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.31889	text	January 2013
Hepatocellular Carcinoma Tirnitz-Parker, Janina E. E. https://doi.org/10.15586/hepatocellularcarcinoma.2019	book	October 2019
Next-Generation Genomic Profiling of Hepatocellular Adenomas: A New Era of Individualized Patient Care Marquardt, Jens U.; Thorgeirsson, Snorri S. Cancer Cell, Vol. 25, Issue 4 https://doi.org/10.1016/j.ccr.2014.03.032	journal	April 2014
Next generation sequencing of HCC from European and Asian HCC cohorts. Back to p53 and Wnt/β-catenin Teufel, Andreas; Marquardt, Jens U.; Galle, Peter R. Journal of Hepatology, Vol. 58, Issue 3 https://doi.org/10.1016/j.jhep.2012.10.006	journal	March 2013
TERT promoter mutations: Gatekeeper and driver of hepatocellular carcinoma Pinyol, Roser; Tovar, Victoria; Llovet, Josep M. Journal of Hepatology, Vol. 61, Issue 3 https://doi.org/10.1016/j.jhep.2014.05.028	journal	September 2014
Liver precancerous lesions and hepatocellular carcinoma: The histology report Roncalli, Massimo; Terracciano, Luigi; Di Tommaso, Luca Digestive and Liver Disease, Vol. 43 https://doi.org/10.1016/s1590-8658(11)60592-6	journal	March 2011
Differences that matter in cancer genomics Ding, Li; Wendl, Michael C. Nature Biotechnology, Vol. 31, Issue 10 https://doi.org/10.1038/nbt.2715	journal	October 2013
Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity Barretina, Jordi; Caponigro, Giordano; Stransky, Nicolas Nature, Vol. 565, Issue 7738 https://doi.org/10.1038/s41586-018-0722-x	journal	December 2018
Safety and efficacy of TACE and gamma knife on hepatocellular carcinoma with portal vein invasion Lu, Xiao-Jie; Dong, Jing; Ji, Li-Juan Gut, Vol. 65, Issue 4 https://doi.org/10.1136/gutjnl-2015-310292	journal	August 2015
Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma Chiang, D. Y.; Villanueva, A.; Hoshida, Y. Cancer Research, Vol. 68, Issue 16 https://doi.org/10.1158/0008-5472.can-08-0742	journal	August 2008
Hepatocellular Carcinoma: Reasons for Phase III Failure and Novel Perspectives on Trial Design Llovet, J. M.; Hernandez-Gea, V. Clinical Cancer Research, Vol. 20, Issue 8 https://doi.org/10.1158/1078-0432.ccr-13-0547	journal	March 2014

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Molecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy: Molecular Signatures in HCC Erstad, Derek J.; Fuchs, Bryan C.; Tanabe, Kenneth K. Cancer, Vol. 124, Issue 15 https://doi.org/10.1002/cncr.31257	journal	April 2018
Gain of FGF4 is a frequent event in KIT/PDGFRA/SDH/RAS‐P WT GIST Urbini, Milena; Indio, Valentina; Tarantino, Giuseppe Genes, Chromosomes and Cancer, Vol. 58, Issue 9 https://doi.org/10.1002/gcc.22753	journal	April 2019
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Understanding mutagenesis through delineation of mutational signatures in human cancer Petljak, Mia; Alexandrov, Ludmil B. Carcinogenesis, Vol. 37, Issue 6 https://doi.org/10.1093/carcin/bgw055	journal	May 2016
Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer Rao, Chinthalapally V.; Asch, Adam S.; Yamada, Hiroshi Y. Carcinogenesis, Vol. 38, Issue 1 https://doi.org/10.1093/carcin/bgw118	journal	November 2016
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Exploring background mutational processes to decipher cancer genetic heterogeneity Goncearenco, Alexander; Rager, Stephanie L.; Li, Minghui Nucleic Acids Research, Vol. 45, Issue W1 https://doi.org/10.1093/nar/gkx367	journal	May 2017
CNApp: quantification of genomic copy number alterations in cancer and integrative analysis to unravel clinical implications Franch-Expósito, Sebastià; Bassaganyas, Laia; Vila-Casadesús, Maria https://doi.org/10.1101/479667	preprint	July 2019
Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs Golkowski, Martin; Lau, Ho-Tak; Chan, Marina Cell Systems https://doi.org/10.1101/849281	journal	November 2019
Single tumor-initiating cells evade immune clearance by recruiting type II macrophages Guo, Xiaocan; Zhao, Yang; Yan, Huan Genes & Development, Vol. 31, Issue 3 https://doi.org/10.1101/gad.294348.116	journal	February 2017
Comprehensive review of Hepatitis B Virus-associated hepatocellular carcinoma research through text mining and big data analytics: Review of HBV-HCC literature using text mining Lee, Wai Yeow; Bachtiar, Maulana; Choo, Cheryl C. S. Biological Reviews, Vol. 94, Issue 2 https://doi.org/10.1111/brv.12457	journal	August 2018
Molecular genomic landscapes of hepatobiliary cancer Shibata, Tatsuhiro; Arai, Yasuhito; Totoki, Yasushi Cancer Science, Vol. 109, Issue 5 https://doi.org/10.1111/cas.13582	journal	April 2018
Spatial and temporal expansion of intrahepatic metastasis by molecularly‐defined clonality in multiple liver cancers Yamamoto, Shogo; Midorikawa, Yutaka; Nagae, Genta Cancer Science, Vol. 111, Issue 2 https://doi.org/10.1111/cas.14282	journal	January 2020
Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma‐like area and metachronous hepatocellular carcinoma Kawai‐Kitahata, Fukiko; Asahina, Yasuhiro; Kaneko, Shun Hepatology Research, Vol. 49, Issue 12 https://doi.org/10.1111/hepr.13403	journal	August 2019
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K‐AKT‐β‐catenin pathways Xie, Lulu; Dai, Hanhan; Li, Minjing Journal of Cellular and Molecular Medicine, Vol. 23, Issue 5 https://doi.org/10.1111/jcmm.14235	journal	February 2019
Clinical implications of omics and systems medicine: focus on predictive and individualized treatment Benson, M. Journal of Internal Medicine, Vol. 279, Issue 3 https://doi.org/10.1111/joim.12412	journal	August 2015
A qualitative signature for early diagnosis of hepatocellular carcinoma based on relative expression orderings Ao, Lu; Zhang, Zimei; Guan, Qingzhou Liver International, Vol. 38, Issue 10 https://doi.org/10.1111/liv.13864	journal	May 2018
TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication Ho, Daniel W. H.; Chan, Lo K.; Chiu, Yung T. Gut, Vol. 66, Issue 8 https://doi.org/10.1136/gutjnl-2016-312734	journal	December 2016
β-catenin-activated hepatocellular carcinomas are addicted to fatty acids Senni, Nadia; Savall, Mathilde; Cabrerizo Granados, David Gut, Vol. 68, Issue 2 https://doi.org/10.1136/gutjnl-2017-315448	journal	April 2018
Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance Xiang, Dai-Min; Sun, Wen; Zhou, Tengfei Gut, Vol. 68, Issue 10 https://doi.org/10.1136/gutjnl-2018-317440	journal	May 2019
Epigenetic modulation of immunity: towards new therapeutic avenues in hepatocellular carcinoma? Gougelet, Angelique Gut, Vol. 68, Issue 10 https://doi.org/10.1136/gutjnl-2019-319084	journal	June 2019
MicroRNA-146a-5p enhances radiosensitivity in hepatocellular carcinoma through replication protein A3-induced activation of the DNA repair pathway Luo, Jing; Si, Zhong-Zhou; Li, Ting American Journal of Physiology-Cell Physiology, Vol. 316, Issue 3 https://doi.org/10.1152/ajpcell.00189.2018	journal	March 2019
Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs Fabrizio, F. P.; Sparaneo, A.; Trombetta, D. Oxidative Medicine and Cellular Longevity, Vol. 2018 https://doi.org/10.1155/2018/2492063	journal	January 2018
Hepatoblastoma modeling in mice places Nrf2 within a cancer field established by mutant β-catenin Comerford, Sarah A.; Hinnant, Elizabeth A.; Chen, Yidong JCI Insight, Vol. 1, Issue 16 https://doi.org/10.1172/jci.insight.88549	journal	October 2016
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma Lee, Derek; Xu, Iris Ming-Jing; Chiu, David Kung-Chun Journal of Clinical Investigation, Vol. 127, Issue 5 https://doi.org/10.1172/jci90253	journal	April 2017
PDXliver: a database of liver cancer patient derived xenograft mouse models He, Sheng; Hu, Bo; Li, Chao BMC Cancer, Vol. 18, Issue 1 https://doi.org/10.1186/s12885-018-4459-6	journal	May 2018
Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells Murakami, Yuko; Sugiyama, Kazuo; Ebinuma, Hirotoshi BMC Cancer, Vol. 18, Issue 1 https://doi.org/10.1186/s12885-018-4588-y	journal	June 2018
Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword Wang, Shaoyun; Chai, Peiwei; Jia, Ruobing Molecular Cancer, Vol. 17, Issue 1 https://doi.org/10.1186/s12943-018-0847-4	journal	July 2018
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours Nwosu, Zeribe C.; Battello, Nadia; Rothley, Melanie Journal of Experimental & Clinical Cancer Research, Vol. 37, Issue 1 https://doi.org/10.1186/s13046-018-0872-6	journal	September 2018
SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway Zhao, Jie; Wozniak, Ann; Adams, Abby Journal of Experimental & Clinical Cancer Research, Vol. 38, Issue 1 https://doi.org/10.1186/s13046-019-1246-4	journal	June 2019
A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers Xu, Shili; Catapang, Arthur; Braas, Daniel Cancer & Metabolism, Vol. 6, Issue 1 https://doi.org/10.1186/s40170-018-0181-8	journal	June 2018
iMutSig: a web application to identify the most similar mutational signature using shiny Yang, Zhi; Pandey, Priyatama; Marjoram, Paul F1000Research, Vol. 9 https://doi.org/10.12688/f1000research.24435.1	journal	January 2020
DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1 Fezza, Maha; Moussa, Mayssam; Aoun, Rita PLOS ONE, Vol. 14, Issue 9 https://doi.org/10.1371/journal.pone.0223252	journal	September 2019
A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis Kroh, Andreas; Walter, Jeanette; Schüler, Herdit RWTH Aachen University https://doi.org/10.18154/rwth-2020-02154	text	January 2019
Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma DeLeon, Thomas T.; Ahn, Daniel H.; Bogenberger, James M. Future Oncology, Vol. 14, Issue 6 https://doi.org/10.2217/fon-2017-0451	journal	March 2018
Molecular Scoring of Hepatocellular Carcinoma for Predicting Metastatic Recurrence and Requirements of Systemic Chemotherapy Nishida, Naoshi; Nishimura, Takafumi; Kaido, Toshimi Cancers, Vol. 10, Issue 10 https://doi.org/10.3390/cancers10100367	journal	September 2018
Lipid Metabolic Reprogramming in Hepatocellular Carcinoma Nakagawa, Hayato; Hayata, Yuki; Kawamura, Satoshi Cancers, Vol. 10, Issue 11 https://doi.org/10.3390/cancers10110447	journal	November 2018
Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance Raghunath, Azhwar; Sundarraj, Kiruthika; Arfuso, Frank Cancers, Vol. 10, Issue 12 https://doi.org/10.3390/cancers10120481	journal	December 2018
Genomic Perspective on Mouse Liver Cancer Models Yim, Sun Young; Lee, Ju-Seog Cancers, Vol. 11, Issue 11 https://doi.org/10.3390/cancers11111648	journal	October 2019
Systemic Chemotherapy for Advanced Hepatocellular Carcinoma: Past, Present, and Future Ikeda, Masafumi; Mitsunaga, Shuichi; Ohno, Izumi Diseases, Vol. 3, Issue 4 https://doi.org/10.3390/diseases3040360	journal	December 2015
Telomere Maintenance Mechanisms in Cancer Gaspar, Tiago Bordeira; Sá, Ana; Lopes, José Manuel Genes, Vol. 9, Issue 5 https://doi.org/10.3390/genes9050241	journal	May 2018
EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe? Yan, Ke-Sin; Lin, Chia-Yuan; Liao, Tan-Wei International Journal of Molecular Sciences, Vol. 18, Issue 6 https://doi.org/10.3390/ijms18061172	journal	May 2017
Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review Kanda, Tatsuo; Goto, Taichiro; Hirotsu, Yosuke International Journal of Molecular Sciences, Vol. 20, Issue 6 https://doi.org/10.3390/ijms20061358	journal	March 2019
Human Liver Regeneration: An Etiology Dependent Process Van Haele, Matthias; Snoeck, Janne; Roskams, Tania International Journal of Molecular Sciences, Vol. 20, Issue 9 https://doi.org/10.3390/ijms20092332	journal	May 2019
Methylation Density Pattern of KEAP1 Gene in Lung Cancer Cell Lines Detected by Quantitative Methylation Specific PCR and Pyrosequencing Fabrizio, Federico; Sparaneo, Angelo; Centra, Flavia International Journal of Molecular Sciences, Vol. 20, Issue 11 https://doi.org/10.3390/ijms20112697	journal	May 2019
Tumor-Stroma Crosstalk Enhances REG3A Expressions that Drive the Progression of Hepatocellular Carcinoma Cho, Yuri; Park, Min Ji; Kim, Koeun International Journal of Molecular Sciences, Vol. 21, Issue 2 https://doi.org/10.3390/ijms21020472	journal	January 2020
Metabolism‐associated molecular classification of hepatocellular carcinoma Yang, Chen; Huang, Xiaowen; Liu, Zhicheng Molecular Oncology, Vol. 14, Issue 4 https://doi.org/10.1002/1878-0261.12639	journal	April 2020
Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin Tao, Junyan; Xu, Emily; Zhao, Yifei Hepatology, Vol. 64, Issue 5 https://doi.org/10.1002/hep.28601	journal	May 2016
Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform Wangensteen, Kirk J.; Wang, Yue J.; Dou, Zhixun Hepatology, Vol. 68, Issue 2 https://doi.org/10.1002/hep.29626	journal	May 2018
TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma: Characteristics of genetic aberrations of hepatocellular carcinoma developed in nonalcoholic fatty liver disease Ki Kim, Soo; Ueda, Yoshihide; Hatano, Etsuro International Journal of Cancer, Vol. 139, Issue 11 https://doi.org/10.1002/ijc.30379	journal	August 2016
Caveolin enhances hepatocellular carcinoma cell metabolism, migration, and invasion in vitro via a hexokinase 2‐dependent mechanism Chai, Fang; Li, Yan; Liu, Keyi Journal of Cellular Physiology, Vol. 234, Issue 2 https://doi.org/10.1002/jcp.27074	journal	August 2018
Genomic profiling of combined hepatocellular‐cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma Joseph, Nancy M.; Tsokos, Christos G.; Umetsu, Sarah E. The Journal of Pathology, Vol. 248, Issue 2 https://doi.org/10.1002/path.5243	journal	February 2019
Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma Chung, Randy; Mittal, Sahil Managing Gastrointestinal Complications of Diabetes https://doi.org/10.1007/978-3-319-48662-8_6	book	January 2017
Reactivation of telomerase in cancer Akincilar, Semih Can; Unal, Bilal; Tergaonkar, Vinay Cellular and Molecular Life Sciences, Vol. 73, Issue 8 https://doi.org/10.1007/s00018-016-2146-9	journal	February 2016
Droplet digital PCR detects high rate of TP53 R249S mutants in cell-free DNA of middle African patients with hepatocellular carcinoma Marchio, Agnès; Amougou Atsama, Marie; Béré, Aubin Clinical and Experimental Medicine, Vol. 18, Issue 3 https://doi.org/10.1007/s10238-018-0502-9	journal	May 2018
Emerging therapies for acute intermittent porphyria Fontanellas, Antonio; Ávila, Matías A.; Berraondo, Pedro Expert Reviews in Molecular Medicine, Vol. 18 https://doi.org/10.1017/erm.2016.18	journal	January 2016
The significance of intertumor and intratumor heterogeneity in liver cancer Liu, Jinping; Dang, Hien; Wang, Xin Wei Experimental & Molecular Medicine, Vol. 50, Issue 1 https://doi.org/10.1038/emm.2017.165	journal	January 2018
Recurrently deregulated lncRNAs in hepatocellular carcinoma Yang, Yang; Chen, Lei; Gu, Jin Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms14421	journal	February 2017
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma Zhai, Weiwei; Lim, Tony Kiat-Hon; Zhang, Tong Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms14565	journal	February 2017
Hepatocellular carcinoma Llovet, Josep M.; Zucman-Rossi, Jessica; Pikarsky, Eli Nature Reviews Disease Primers, Vol. 2, Issue 1 https://doi.org/10.1038/nrdp.2016.18	journal	April 2016
A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma Labgaa, Ismail; Villacorta-Martin, Carlos; D’Avola, Delia Oncogene, Vol. 37, Issue 27 https://doi.org/10.1038/s41388-018-0206-3	journal	April 2018
From NASH to HCC: current concepts and future challenges Anstee, Quentin M.; Reeves, Helen L.; Kotsiliti, Elena Nature Reviews Gastroenterology & Hepatology, Vol. 16, Issue 7 https://doi.org/10.1038/s41575-019-0145-7	journal	April 2019
Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma Chen, Bin; Garmire, Lana; Calvisi, Diego F. Nature Reviews Gastroenterology & Hepatology, Vol. 17, Issue 4 https://doi.org/10.1038/s41575-019-0240-9	journal	January 2020
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma Jiang, Ying; Sun, Aihua; Zhao, Yang Nature, Vol. 567, Issue 7747 https://doi.org/10.1038/s41586-019-0987-8	journal	February 2019
Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer Xiao, Qingyu; Sun, Yidi; Dobi, Albert Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-30325-9	journal	August 2018
CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice Weber, Julia; Öllinger, Rupert; Friedrich, Mathias Proceedings of the National Academy of Sciences, Vol. 112, Issue 45 https://doi.org/10.1073/pnas.1512392112	journal	October 2015
Mutational spectra of aflatoxin B ₁ in vivo establish biomarkers of exposure for human hepatocellular carcinoma Chawanthayatham, Supawadee; Valentine, Charles C.; Fedeles, Bogdan I. Proceedings of the National Academy of Sciences, Vol. 114, Issue 15 https://doi.org/10.1073/pnas.1700759114	journal	March 2017
Viral hepatitis and liver cancer Ringehan, Marc; McKeating, Jane A.; Protzer, Ulrike Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 372, Issue 1732 https://doi.org/10.1098/rstb.2016.0274	journal	September 2017
Mutational signatures associated with tobacco smoking in human cancer Alexandrov, Ludmil B.; Ju, Young Seok; Haase, Kerstin bioRxiv https://doi.org/10.1101/051417	posted_content	May 2016
Computational approaches for discovery of mutational signatures in cancer Baez-Ortega, Adrian; Gori, Kevin https://doi.org/10.1101/154716	posted_content	June 2017
SigLASSO: a LASSO approach jointly optimizing sampling likelihood and cancer mutation signatures Li, Shantao; Crawford, Forrest W.; Gerstein, Mark B. Nature Communications https://doi.org/10.1101/366740	posted_content	May 2018
Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis Virzì, Alessia; Roca Suarez, Armando Andres; Baumert, Thomas F. Cold Spring Harbor Perspectives in Medicine, Vol. 10, Issue 1 https://doi.org/10.1101/cshperspect.a037366	journal	September 2019
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma Dayton, Talya L.; Gocheva, Vasilena; Miller, Kathryn M. Genes & Development, Vol. 30, Issue 9 https://doi.org/10.1101/gad.278549.116	journal	April 2016
Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription Patitucci, Cecilia; Couchy, Gabrielle; Bagattin, Alessia Journal of Clinical Investigation, Vol. 127, Issue 5 https://doi.org/10.1172/jci90327	journal	April 2017
Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems Soto-Gutierrez, Alejandro; Gough, Albert; Vernetti, Lawrence A. Experimental Biology and Medicine, Vol. 242, Issue 16 https://doi.org/10.1177/1535370217707731	journal	May 2017
The biology of Hepatocellular carcinoma: implications for genomic and immune therapies Khemlina, Galina; Ikeda, Sadakatsu; Kurzrock, Razelle Molecular Cancer, Vol. 16, Issue 1 https://doi.org/10.1186/s12943-017-0712-x	journal	August 2017
Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients Petrizzo, Annacarmen; Tagliamonte, Maria; Mauriello, Angela Journal of Translational Medicine, Vol. 16, Issue 1 https://doi.org/10.1186/s12967-018-1662-9	journal	October 2018
MutationalPatterns: comprehensive genome-wide analysis of mutational processes Blokzijl, Francis; Janssen, Roel; van Boxtel, Ruben Genome Medicine, Vol. 10, Issue 1 https://doi.org/10.1186/s13073-018-0539-0	journal	April 2018
Circulating tumor DNA in hepatocellular carcinoma: trends and challenges Tang, Jia-Cheng; Feng, Yi-Li; Guo, Tao Cell & Bioscience, Vol. 6, Issue 1 https://doi.org/10.1186/s13578-016-0100-z	journal	May 2016
Fibroblast Growth Factor 15/19: From Basic Functions to Therapeutic Perspectives Somm, Emmanuel; Jornayvaz, François R. Endocrine Reviews, Vol. 39, Issue 6 https://doi.org/10.1210/er.2018-00134	journal	August 2018
Actual 10-Year Survivors After Resection of Hepatocellular Carcinoma Zheng, Jian; Kuk, Deborah; Gönen, Mithat Annals of Surgical Oncology, Vol. 24, Issue 5 https://doi.org/10.1245/s10434-016-5713-2	journal	December 2016
Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances Dhanasekaran, Renumathy; Bandoh, Salome; Roberts, Lewis R. F1000Research, Vol. 5 https://doi.org/10.12688/f1000research.6946.1	journal	January 2016
Multiple m6A RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis Qu, Nanfang; Qin, Sanyu; Zhang, Xuemei https://doi.org/10.21203/rs.2.17504/v2	preprint	February 2020
Transcriptome Analysis Revealed a Highly Connected Gene Module Associated With Cirrhosis to Hepatocellular Carcinoma Development Shan, Shan; Chen, Wei; Jia, Ji-dong Frontiers in Genetics, Vol. 10 https://doi.org/10.3389/fgene.2019.00305	journal	April 2019
The KEAP1–NRF2 System in Cancer Taguchi, Keiko; Yamamoto, Masayuki Frontiers in Oncology, Vol. 7 https://doi.org/10.3389/fonc.2017.00085	journal	May 2017
Animal Models of Hepatocellular Carcinoma: The Role of Immune System and Tumor Microenvironment Macek Jilkova, Zuzana; Kurma, Keerthi; Decaens, Thomas Cancers, Vol. 11, Issue 10 https://doi.org/10.3390/cancers11101487	journal	October 2019
Genetically Engineered Mouse Models for Liver Cancer Cho, Kyungjoo; Ro, Simon Weonsang; Seo, Sang Hyun Cancers, Vol. 12, Issue 1 https://doi.org/10.3390/cancers12010014	journal	December 2019
Hepatitis B Virus-Associated Hepatocellular Carcinoma and Hepatic Cancer Stem Cells Mani, Saravana; Andrisani, Ourania Genes, Vol. 9, Issue 3, p. 137 https://doi.org/10.3390/genes9030137	journal	March 2018
Molecular Targets in Hepatocarcinogenesis and Implications for Therapy Wu, Meng-Yu; Yiang, Giuo-Teng; Cheng, Pei-Wen Journal of Clinical Medicine, Vol. 7, Issue 8 https://doi.org/10.3390/jcm7080213	journal	August 2018
Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook Y., Ng, Charlotte K.; Giuseppe, Di Costanzo, Giovan; M., Terracciano, Luigi Frontiers Media https://doi.org/10.5451/unibas-ep68146	text	January 2018
CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications Franch-Expósito, Sebastià; Bassaganyas, Laia; Vila-Casadesús, Maria eLife, Vol. 9 https://doi.org/10.7554/elife.50267	journal	January 2020
Identification of crucial genes based on expression profiles of hepatocellular carcinomas by bioinformatics analysis Liu, Ze-Kun; Zhang, Ren-Yu; Yong, Yu-Le PeerJ, Vol. 7 https://doi.org/10.7717/peerj.7436	journal	January 2019
Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma. Gerbes, Alexander; Zoulim, Fabien; Tilg, Herbert BMJ Publishing Group https://doi.org/10.7892/boris.108695	text	January 2018
Dual Targeting of Histone Methyltransferase G9a and DNA‐Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma Bárcena‐Varela, Marina; Caruso, Stefano; Llerena, Susana Hepatology, Vol. 69, Issue 2 https://doi.org/10.1002/hep.30168	journal	January 2019
Challenges and Opportunities in the Clinical Development of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma Flynn, Michael J.; Sayed, Anwar A.; Sharma, Rohini Hepatology, Vol. 69, Issue 5 https://doi.org/10.1002/hep.30337	journal	February 2019
Mammalian Target of Rapamycin Inhibitors, New Drugs for Beta‐Catenin–Mutated Hepatocellular Carcinomas? Perret, Christine; Decaens, Thomas Hepatology, Vol. 70, Issue 4 https://doi.org/10.1002/hep.30768	journal	May 2019
Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma Nault, Jean‐Charles; Martin, Yoann; Caruso, Stefano Hepatology, Vol. 71, Issue 1 https://doi.org/10.1002/hep.30811	journal	January 2020
Clonal evolution in long-term follow-up patients with hepatocellular carcinoma: Clonal evolution in long-term follow-up patients with hepatocellular carcinoma Chen, Geng; Cai, Zhixiong; Li, Zhenli International Journal of Cancer, Vol. 143, Issue 11 https://doi.org/10.1002/ijc.31844	journal	October 2018
Mutated EPHA2 is a target for combating lymphatic metastasis in intrahepatic cholangiocarcinoma Sheng, Yuanyuan; Wei, Jinwang; Zhang, Yu International Journal of Cancer, Vol. 144, Issue 10 https://doi.org/10.1002/ijc.31979	journal	January 2019
Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and Pathogenesis Wainwright, P.; Scorletti, E.; Byrne, C. D. Current Diabetes Reports, Vol. 17, Issue 4 https://doi.org/10.1007/s11892-017-0851-x	journal	March 2017
Goals and targets for personalized therapy for HCC Couri, Thomas; Pillai, Anjana Hepatology International, Vol. 13, Issue 2 https://doi.org/10.1007/s12072-018-9919-1	journal	January 2019
Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing Duan, Meng; Hao, Junfeng; Cui, Sijia Cell Research, Vol. 28, Issue 3 https://doi.org/10.1038/cr.2018.11	journal	January 2018
The protein histidine phosphatase LHPP is a tumour suppressor Hindupur, Sravanth K.; Colombi, Marco; Fuhs, Stephen R. Nature, Vol. 555, Issue 7698 https://doi.org/10.1038/nature26140	journal	March 2018
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas Nault, Jean-Charles; Datta, Shalini; Imbeaud, Sandrine Nature Genetics, Vol. 47, Issue 10 https://doi.org/10.1038/ng.3389	journal	August 2015
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening Broutier, Laura; Mastrogiovanni, Gianmarco; Verstegen, Monique MA Nature Medicine, Vol. 23, Issue 12 https://doi.org/10.1038/nm.4438	journal	November 2017
Functional and genetic deconstruction of the cellular origin in liver cancer Marquardt, Jens U.; Andersen, Jesper B.; Thorgeirsson, Snorri S. Nature Reviews Cancer, Vol. 15, Issue 11 https://doi.org/10.1038/nrc4017	journal	October 2015
ZNF774 is a potent suppressor of hepatocarcinogenesis through dampening the NOTCH2 signaling Guan, Chengjian; He, Lin; Chang, Zhenyu Oncogene, Vol. 39, Issue 8 https://doi.org/10.1038/s41388-019-1075-0	journal	October 2019
DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma Mizuno, Yuki; Shimada, Shu; Akiyama, Yoshimitsu Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-017-18323-9	journal	January 2018
De Novo Mutational Signature Discovery in Tumor Genomes using SparseSignatures Ramazzotti, Daniele; Lal, Avantika; Liu, Keli https://doi.org/10.1101/384834	posted_content	June 2019
Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/Taz Bisso, Andrea; Filipuzzi, Marco; Gamarra Figueroa, Gianni Paolo https://doi.org/10.1101/819631	posted_content	October 2019
Klotho‐beta and fibroblast growth factor 19 expression correlates with early recurrence of resectable hepatocellular carcinoma Lin, Zhong‐Zhe; Hsu, Chiun; Jeng, Yung‐Ming Liver International, Vol. 39, Issue 9 https://doi.org/10.1111/liv.14055	journal	July 2019
Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia Ng, Alvin W. T.; Poon, Song Ling; Huang, Mi Ni Science Translational Medicine, Vol. 9, Issue 412 https://doi.org/10.1126/scitranslmed.aan6446	journal	October 2017
Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma Bollard, Julien; Miguela, Verónica; Ruiz de Galarreta, Marina Gut, Vol. 66, Issue 7 https://doi.org/10.1136/gutjnl-2016-312268	journal	November 2016
Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression Shen, Jialing; Chen, Mengnuo; Lee, Derek Gut, Vol. 69, Issue 2 https://doi.org/10.1136/gutjnl-2019-318668	journal	August 2019
Of FACT complex and oxidative stress response: a KEAP1/NRF2-dependent novel mechanism sustaining hepatocellular carcinoma progression Foglia, Beatrice; Parola, Maurizio Gut, Vol. 69, Issue 2 https://doi.org/10.1136/gutjnl-2019-319609	journal	October 2019
Performance comparison of three DNA extraction kits on human whole-exome data from formalin-fixed paraffin-embedded normal and tumor samples Bonnet, Eric; Moutet, Marie-Laure; Baulard, Céline PLOS ONE, Vol. 13, Issue 4 https://doi.org/10.1371/journal.pone.0195471	journal	April 2018
Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice Ferrara-Romeo, Iole; Martínez, Paula; Blasco, Maria A. PLOS ONE, Vol. 13, Issue 10 https://doi.org/10.1371/journal.pone.0204909	journal	October 2018
Computational approaches for discovery of mutational signatures in cancer. Baez-Ortega, Adrian; Gori, Kevin Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.11113	text	January 2019
The repertoire of mutational signatures in human cancer Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.64271	text	January 2020
Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease Itoh, Nobuyuki; Nakayama, Yoshiaki; Konishi, Morichika Frontiers in Cell and Developmental Biology, Vol. 4 https://doi.org/10.3389/fcell.2016.00030	journal	April 2016
A Guide to PIN1 Function and Mutations Across Cancers El Boustani, Maguie; De Stefano, Lucia; Caligiuri, Isabella Frontiers in Pharmacology, Vol. 9 https://doi.org/10.3389/fphar.2018.01477	journal	January 2019
A Newly Established Murine Cell Line as a Model for Hepatocellular Cancer in Non-Alcoholic Steatohepatitis Kroh, Andreas; Walter, Jeanette; Schüler, Herdit International Journal of Molecular Sciences, Vol. 20, Issue 22 https://doi.org/10.3390/ijms20225658	journal	November 2019
Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma Mukaida, Naofumi; Nakamoto, Yasunari World Journal of Gastroenterology, Vol. 24, Issue 17 https://doi.org/10.3748/wjg.v24.i17.1839	journal	May 2018
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours Nwosu, Z. C.; Battello, N.; Rothley, M. Karlsruhe https://doi.org/10.5445/ir/1000085876	text	January 2018
Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology Tanaka, Shinji Annals of Gastroenterological Surgery, Vol. 2, Issue 2 https://doi.org/10.1002/ags3.12059	journal	January 2018
Theranostical nanosystem-mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma: HEPATOLOGY, Vol. XX, No. X, 2016 Guo, Yu; Wang, Jing; Zhang, Lu Hepatology, Vol. 63, Issue 4 https://doi.org/10.1002/hep.28409	journal	February 2016
Programmed death ligand 1 expression in hepatocellular carcinoma: Relationship With clinical and pathological features: HEPATOBILIARY MALIGNANCIES Calderaro, Julien; Rousseau, Benoît; Amaddeo, Giuliana Hepatology, Vol. 64, Issue 6 https://doi.org/10.1002/hep.28710	journal	August 2016
PI3Kδ Is a Therapeutic Target in Hepatocellular Carcinoma: Hepatology Ko, Eunkyong; Seo, Hyun-Wook; Jung, Eun Sun Hepatology, Vol. 68, Issue 6 https://doi.org/10.1002/hep.30307	journal	November 2018
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases Yang, Jie; Trépo, Eric; Nahon, Pierre International Journal of Cancer, Vol. 144, Issue 3 https://doi.org/10.1002/ijc.31910	journal	November 2018
C3HeB/FeJ Mice mimic many aspects of gene expression and pathobiological features of human hepatocellular carcinoma Zavadil, Jessica A.; Herzig, Maryanne C. S.; Hildreth, Kim Molecular Carcinogenesis, Vol. 58, Issue 3 https://doi.org/10.1002/mc.22929	journal	November 2018
Biomarkers: What Role Do They Play (If Any) for Diagnosis, Prognosis and Tumor Response Prediction for Hepatocellular Carcinoma? Harding, James J.; Khalil, Danny N.; Abou-Alfa, Ghassan K. Digestive Diseases and Sciences, Vol. 64, Issue 4 https://doi.org/10.1007/s10620-019-05517-6	journal	March 2019
Liquid Biopsy for Hepatocellular Carcinoma Chen, Vincent L.; Parikh, Neehar D. Current Hepatology Reports, Vol. 18, Issue 4 https://doi.org/10.1007/s11901-019-00491-z	journal	October 2019
Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents Merlevede, Jane; Droin, Nathalie; Qin, Tingting Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms10767	journal	February 2016
Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis Wang, Ben-Gang; Jiang, Li-Yue; Xu, Qian Bioscience Reports, Vol. 38, Issue 5 https://doi.org/10.1042/bsr20180712	journal	September 2018
Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction Zhang, Cheng; Ge, Shuang; Wang, Jun Journal of Gastroenterology and Hepatology, Vol. 34, Issue 10 https://doi.org/10.1111/jgh.14694	journal	March 2019
Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma Gerbes, Alexander; Zoulim, Fabien; Tilg, Herbert Gut, Vol. 67, Issue 2 https://doi.org/10.1136/gutjnl-2017-315068	journal	November 2017
Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma Kutlu, Ozlem; Kaleli, Humeyra Nur; Ozer, Ebru Canadian Journal of Gastroenterology and Hepatology, Vol. 2018 https://doi.org/10.1155/2018/8543763	journal	August 2018
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC Shen, Tingting; Lu, Yunfei; Zhang, Qin Cancer Control, Vol. 27, Issue 1 https://doi.org/10.1177/1073274820914663	journal	January 2020
Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma Jin, Yu; Lee, Wai Yeow; Toh, Soo Ting Journal of Translational Medicine, Vol. 17, Issue 1 https://doi.org/10.1186/s12967-019-2025-x	journal	August 2019
De novo mutational signature discovery in tumor genomes using SparseSignatures Lal, Avantika; Liu, Keli; Tibshirani, Robert PLOS Computational Biology, Vol. 17, Issue 6 https://doi.org/10.1371/journal.pcbi.1009119	journal	June 2021
SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types Richtig, Georg; Aigelsreiter, Ariane; Schwarzenbacher, Daniela PLOS ONE, Vol. 12, Issue 11 https://doi.org/10.1371/journal.pone.0187814	journal	November 2017
The heterogeneity of plasma miRNA profiles in hepatocellular carcinoma patients and the exploration of diagnostic circulating miRNAs for hepatocellular carcinoma Bai, Xue; Liu, Zhenzhen; Shao, Xiaojian PLOS ONE, Vol. 14, Issue 2 https://doi.org/10.1371/journal.pone.0211581	journal	February 2019
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Brunner, Simon F.; Roberts, Nicola D.; Wylie, Luke A. Apollo - University of Cambridge Repository https://doi.org/10.17863/cam.44643	text	January 2019
Positive Immuno-Modulation Following Radiofrequency Assisted Liver Resection in Hepatocellular Carcinoma Huang, Kai Wen; Jayant, Kumar; Lee, Po-Huang Journal of Clinical Medicine, Vol. 8, Issue 3 https://doi.org/10.3390/jcm8030385	journal	March 2019
Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4–MMP1 axis Kim, Eunjeong; Kim, Donghyo; Lee, Jeon‐Soo Hepatology, Vol. 67, Issue 6 https://doi.org/10.1002/hep.29738	journal	April 2018
Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma Wang, Wenhui; Pan, Qiuwei; Fuhler, Gwenny M. Journal of Gastroenterology, Vol. 52, Issue 4 https://doi.org/10.1007/s00535-016-1299-5	journal	December 2016
The therapeutic significance of mutational signatures from DNA repair deficiency in cancer Ma, Jennifer; Setton, Jeremy; Lee, Nancy Y. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-05228-y	journal	August 2018
The effects of mutational processes and selection on driver mutations across cancer types Temko, Daniel; Tomlinson, Ian P. M.; Severini, Simone bioRxiv https://doi.org/10.1101/149096	posted_content	June 2017
Alterations of EDEM 1 functions enhance ATF 6 pro‐survival signaling Papaioannou, Alexandra; Higa, Arisa; Jégou, Gwénaële The FEBS Journal, Vol. 285, Issue 22 https://doi.org/10.1111/febs.14669	journal	October 2018
Multiple m6A RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis Qu, Nanfang; Qin, Sanyu; Zhang, Xuemei BMC Cancer, Vol. 20, Issue 1 https://doi.org/10.1186/s12885-020-6638-5	journal	February 2020
Molecular profiling for precision cancer therapies Malone, Eoghan R.; Oliva, Marc; Sabatini, Peter J. B. Genome Medicine, Vol. 12, Issue 1 https://doi.org/10.1186/s13073-019-0703-1	journal	January 2020
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing Zheng, Jian; Sadot, Eran; Vigidal, Joana A. PLOS ONE, Vol. 13, Issue 7 https://doi.org/10.1371/journal.pone.0200776	journal	July 2018
Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer Hlady, Ryan A.; Zhou, Dan; Puszyk, William Taylor & Francis https://doi.org/10.6084/m9.figshare.4524875.v2	audiovisual	January 2017
Integrative analysis of highly mutated genes in hepatitis B virus‐related hepatic carcinoma Kong, Fanyun; Kong, Delong; Yang, Xiaoying Cancer Medicine, Vol. 9, Issue 7 https://doi.org/10.1002/cam4.2903	journal	April 2020
Comparison of hepatocellular carcinoma in Eastern versus Western populations: Hepatocellular Carcinoma: East vs West Choo, Su Pin; Tan, Wan Ling; Goh, Brian K. P. Cancer, Vol. 122, Issue 22 https://doi.org/10.1002/cncr.30237	journal	September 2016
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity Shalapour, Shabnam; Lin, Xue-Jia; Bastian, Ingmar N. Nature, Vol. 551, Issue 7680 https://doi.org/10.1038/nature24302	journal	November 2017
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Saito, Tetsuya; Ichimura, Yoshinobu; Taguchi, Keiko Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12030	journal	June 2016
The effects of mutational processes and selection on driver mutations across cancer types Temko, Daniel; Tomlinson, Ian P. M.; Severini, Simone Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04208-6	journal	May 2018
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53 -deficient cancers to mTOR inhibition Kong, Na; Tao, Wei; Ling, Xiang Science Translational Medicine, Vol. 11, Issue 523 https://doi.org/10.1126/scitranslmed.aaw1565	journal	December 2019
Polyploidy spectrum: a new marker in HCC classification Bou-Nader, Myriam; Caruso, Stefano; Donne, Romain Gut, Vol. 69, Issue 2 https://doi.org/10.1136/gutjnl-2018-318021	journal	April 2019
Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma Pezzuto, Francesca; Buonaguro, Luigi; Buonaguro, Franco M. Infectious Agents and Cancer, Vol. 12, Issue 1 https://doi.org/10.1186/s13027-017-0138-5	journal	May 2017
iMutSig: a web application to identify the most similar mutational signature using shiny Yang, Zhi; Pandey, Priyatama; Marjoram, Paul F1000Research, Vol. 9 https://doi.org/10.12688/f1000research.24435.2	journal	January 2020
Nonalcoholic fatty liver disease and hepatocellular carcinoma Klein, Stephanie; Dufour, Jean-François Hepatic Oncology, Vol. 4, Issue 3 https://doi.org/10.2217/hep-2017-0013	journal	July 2017
Molecular classification of hepatocellular carcinoma: potential therapeutic implications Goossens, Nicolas; Sun, Xiaochen; Hoshida, Yujin Hepatic Oncology, Vol. 2, Issue 4 https://doi.org/10.2217/hep.15.26	journal	October 2015
Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors Jiao, Jingjing; Watt, Gordon P.; Stevenson, Heather L. Hepatology Communications, Vol. 2, Issue 6 https://doi.org/10.1002/hep4.1187	journal	April 2018
A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer Viel, Alessandra; Bruselles, Alessandro; Meccia, Ettore EBioMedicine, Vol. 20 https://doi.org/10.1016/j.ebiom.2017.04.022	journal	June 2017
Comprehensive molecular and immunological characterization of hepatocellular carcinoma Shimada, Shu; Mogushi, Kaoru; Akiyama, Yoshimitsu EBioMedicine, Vol. 40 https://doi.org/10.1016/j.ebiom.2018.12.058	journal	February 2019
Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma Nwosu, Zeribe Chike; Megger, Dominik Andre; Hammad, Seddik Cellular and Molecular Gastroenterology and Hepatology, Vol. 4, Issue 2 https://doi.org/10.1016/j.jcmgh.2017.05.004	journal	September 2017
There Is Something Fishy About Liver Cancer: Zebrafish Models of Hepatocellular Carcinoma Wrighton, Paul J.; Oderberg, Isaac M.; Goessling, Wolfram Cellular and Molecular Gastroenterology and Hepatology, Vol. 8, Issue 3 https://doi.org/10.1016/j.jcmgh.2019.05.002	journal	January 2019
Toward a Better Understanding of Hepatocellular Carcinoma Immune Infiltrates Buettner, Nico; Thimme, Robert Cellular and Molecular Gastroenterology and Hepatology, Vol. 9, Issue 2 https://doi.org/10.1016/j.jcmgh.2019.11.007	journal	January 2020
Base changes in tumour DNA have the power to reveal the causes and evolution of cancer Hollstein, M.; Alexandrov, L. B.; Wild, C. P. Oncogene, Vol. 36, Issue 2 https://doi.org/10.1038/onc.2016.192	journal	June 2016
The PI3K inhibitor copanlisib synergizes with sorafenib to induce cell death in hepatocellular carcinoma Ye, Liangtao; Mayerle, Julia; Ziesch, Andreas Cell Death Discovery, Vol. 5, Issue 1 https://doi.org/10.1038/s41420-019-0165-7	journal	April 2019
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism Chen, Ting-Wen; Lee, Chi-Ching; Liu, Hsuan Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00493-9	journal	September 2017
Author Correction: The effects of mutational processes and selection on driver mutations across cancer types Temko, Daniel; Tomlinson, Ian P. M.; Severini, Simone Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-15800-0	journal	April 2020
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers Qiu, Zhixin; Zou, Keke; Zhuang, Liping Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep27411	journal	June 2016
Distinct domains of the β1-subunit cytosolic N terminus control surface expression and functional properties of large-conductance calcium-activated potassium (BK) channels Chen, Lie; Bi, Danlei; Lu, Zen Huat Journal of Biological Chemistry, Vol. 292, Issue 21 https://doi.org/10.1074/jbc.m116.769505	journal	May 2017
Early detection of the aflatoxin B₁ mutational fingerprint: A diagnostic tool for liver cancer Fedeles, Bogdan I.; Chawanthayatham, Supawadee; Croy, Robert G. Molecular & Cellular Oncology, Vol. 4, Issue 4 https://doi.org/10.1080/23723556.2017.1329693	journal	May 2017
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks Lin, Shengda; Yin, Yi A.; Jiang, Xiaoqian BioMed Research International, Vol. 2016 https://doi.org/10.1155/2016/6186281	journal	January 2016
New Insights into the Epigenetics of Hepatocellular Carcinoma Wahid, Braira; Ali, Amjad; Rafique, Shazia BioMed Research International, Vol. 2017 https://doi.org/10.1155/2017/1609575	journal	January 2017
The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma Ahn, Sung-Min; Haq, Farhan; Park, Inkeun BMC Cancer, Vol. 18, Issue 1 https://doi.org/10.1186/s12885-018-4192-1	journal	May 2018
Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours Nwosu, Zeribe C.; Battello, Nadia; Rothley, Melanie Journal of Experimental & Clinical Cancer Research, Vol. 37, Issue 1 https://doi.org/10.1186/s13046-018-0939-4	journal	November 2018
Epigenomic annotation of noncoding mutations identifies mutated pathways in primary liver cancer Lowdon, Rebecca F.; Wang, Ting PLOS ONE, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pone.0174032	journal	March 2017
aCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations Renault, Victor; Tost, Jörg; Pichon, Fabien PLOS ONE, Vol. 12, Issue 12 https://doi.org/10.1371/journal.pone.0189334	journal	December 2017
Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression Duan, Yujie; Tian, Ling; Gao, Qingzhu Oncotarget, Vol. 7, Issue 29 https://doi.org/10.18632/oncotarget.10244	journal	June 2016
Mutations acquired by hepatocellular carcinoma recurrence give rise to an aggressive phenotype Choi, Ji-Hye; Kim, Min Jae; Park, Yong Keun Oncotarget, Vol. 8, Issue 14 https://doi.org/10.18632/oncotarget.14248	journal	December 2016
Silencing of karyopherin α2 inhibits cell growth and survival in human hepatocellular carcinoma Yang, Yunfeng; Guo, Jian; Hao, Yuxia Oncotarget, Vol. 8, Issue 22 https://doi.org/10.18632/oncotarget.16749	journal	March 2017
Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach Gentilini, Davide; Scala, Stefania; Gaudenzi, Germano Oncotarget, Vol. 8, Issue 26 https://doi.org/10.18632/oncotarget.17462	journal	April 2017
Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy Ding, Xiao-Xiao; Zhu, Qing-Ge; Zhang, Shi-Ming Oncotarget, Vol. 8, Issue 33 https://doi.org/10.18632/oncotarget.18382	journal	June 2017
The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles Volinia, Stefano; Druck, Teresa; Paisie, Carolyn A. Oncotarget, Vol. 8, Issue 60 https://doi.org/10.18632/oncotarget.22321	journal	November 2017
Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections Tornesello, Maria Lina; Buonaguro, Luigi; Izzo, Francesco Oncotarget, Vol. 7, Issue 18 https://doi.org/10.18632/oncotarget.7837	journal	March 2016
Dual oncogenic and tumor suppressor roles of the promyelocytic leukemia gene in hepatocarcinogenesis associated with hepatitis B virus surface antigen Chung, Yih-Lin; Wu, Mei-Ling Oncotarget, Vol. 7, Issue 19 https://doi.org/10.18632/oncotarget.8613	journal	April 2016
Cancer Metabolism as a Mechanism of Treatment Resistance and Potential Therapeutic Target in Hepatocellular Carcinoma Lee, Misu; Ko, Haeyong; Yun, Mijin Yonsei Medical Journal, Vol. 59, Issue 10 https://doi.org/10.3349/ymj.2018.59.10.1143	journal	January 2018
Host and Viral Genetic Variation in HBV-Related Hepatocellular Carcinoma An, Ping; Xu, Jinghang; Yu, Yanyan Frontiers in Genetics, Vol. 9 https://doi.org/10.3389/fgene.2018.00261	journal	July 2018
Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook Ng, Charlotte K. Y.; Di Costanzo, Giovan Giuseppe; Terracciano, Luigi M. Frontiers in Medicine, Vol. 5 https://doi.org/10.3389/fmed.2018.00078	journal	March 2018
MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma Li, Hao; Fu, Xiaoyan; Yao, Fan Frontiers in Oncology, Vol. 9 https://doi.org/10.3389/fonc.2019.01278	journal	December 2019
Overexpression of p62/IMP2 can Promote Cell Migration in Hepatocellular Carcinoma via Activation of the Wnt/β-Catenin Pathway Xing, Mengtao; Li, Pei; Wang, Xiao Cancers, Vol. 12, Issue 1 https://doi.org/10.3390/cancers12010007	journal	December 2019
Chaperone-Mediated Autophagy in the Liver: Good or Bad? Dash, Srikanta; Aydin, Yucel; Moroz, Krzysztof Cells, Vol. 8, Issue 11 https://doi.org/10.3390/cells8111308	journal	October 2019
A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma Faltermeier, Claire; Busuttil, Ronald; Zarrinpar, Ali Diseases, Vol. 3, Issue 4 https://doi.org/10.3390/diseases3040221	journal	September 2015
A Comprehensive Analysis of Argonaute-CLIP Data Identifies Novel, Conserved and Species-Specific Targets of miR-21 in Human Liver and Hepatocellular Carcinoma Koenig, Aaron; Barajas, Juan; Guerrero, María International Journal of Molecular Sciences, Vol. 19, Issue 3 https://doi.org/10.3390/ijms19030851	journal	March 2018
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway Xie, Lulu; Li, Minjing; Liu, Desheng Molecules, Vol. 24, Issue 3 https://doi.org/10.3390/molecules24030393	journal	January 2019
Genetic alterations in hepatocellular carcinoma: An update Niu, Zhao-Shan; Niu, Xiao-Jun; Wang, Wen-Hong World Journal of Gastroenterology, Vol. 22, Issue 41 https://doi.org/10.3748/wjg.v22.i41.9069	journal	January 2016
Dimensions of hepatocellular carcinoma phenotypic diversity Désert, Romain; Nieto, Natalia; Musso, Orlando World Journal of Gastroenterology, Vol. 24, Issue 40 https://doi.org/10.3748/wjg.v24.i40.4536	journal	October 2018
Role of liver biopsy in hepatocellular carcinoma Tommaso, Luca Di; Spadaccini, Marco; Donadon, Matteo World Journal of Gastroenterology, Vol. 25, Issue 40 https://doi.org/10.3748/wjg.v25.i40.6041	journal	October 2019
Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis Yang, Xia; Wang, Han‑Lin; Liang, Hai‑Wei Experimental and Therapeutic Medicine https://doi.org/10.3892/etm.2018.5836	journal	February 2018
Implications of driver genes associated with a high tumor mutation burden identified using next‑generation sequencing on immunotherapy in hepatocellular carcinoma Li, Li; Rao, Xiaosong; Wen, Zhaohong Oncology Letters https://doi.org/10.3892/ol.2020.11372	journal	February 2020
Aberrantly DNA Methylated-Differentially Expressed Genes and Pathways in Hepatocellular Carcinoma Cai, Changzhou; Wang, Weilin; Tu, Zhenhua Journal of Cancer, Vol. 10, Issue 2 https://doi.org/10.7150/jca.27832	journal	January 2019
Prognostic analysis of histopathological images using pre-trained convolutional neural networks: application to hepatocellular carcinoma Lu, Liangqun; Daigle, Bernie J. PeerJ, Vol. 8 https://doi.org/10.7717/peerj.8668	journal	March 2020

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