Tools for the Microbiome: Nano and Beyond

Biteen, Julie S.; Blainey, Paul C.; Cardon, Zoe G.; Chun, Miyoung; Church, George M.; Dorrestein, Pieter C.; Fraser, Scott E.; Gilbert, Jack A.; Jansson, Janet K.; Knight, Rob; Miller, Jeff F.; Ozcan, Aydogan; Prather, Kimberly A.; Quake, Stephen R.; Ruby, Edward G.; Silver, Pamela A.; Taha, Sharif; van den Engh, Ger; Weiss, Paul S.; Wong, Gerard C. L.; Wright, Aaron T.; Young, Thomas D.

doi:10.1021/acsnano.5b07826

Title: Tools for the Microbiome: Nano and Beyond

Journal Article · Tue Dec 22 00:00:00 EST 2015 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.5b07826· OSTI ID:1233975

Biteen, Julie S. ^[1]; Blainey, Paul C. ^[2]; Cardon, Zoe G. ^[3]; Chun, Miyoung ^[4]; Church, George M. ^[5]; Dorrestein, Pieter C.; Fraser, Scott E. ^[6]; Gilbert, Jack A. ^[7]; Jansson, Janet K. ^[8]; Knight, Rob; Miller, Jeff F.; Ozcan, Aydogan; Prather, Kimberly A.; Quake, Stephen R.; Ruby, Edward G. ^[9]; Silver, Pamela A. ^[5]; Taha, Sharif ^[4]; van den Engh, Ger ^[10]; Weiss, Paul S.; Wong, Gerard C. L. more »

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States
Department of Biological Engineering, Massachusetts Institute of Technology, and Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02138, United States
The Ecosystems Center, Marine Biological Laboratory, Woods Hole, Massachusetts 02543-1015, United States
The Kavli Foundation, Oxnard, California 93030, United States
Wyss Institute for Biologically Inspired Engineering and Biophysics Program, Harvard University, Boston, Massachusetts 02115, United States
Translational Imaging Center, University of Southern California, Molecular and Computational Biology, Los Angeles, California 90089, United States
Institute for Genomic and Systems Biology, Argonne National Laboratory, Argonne, Illinois 60439, United States, Department of Ecology and Evolution and Department of Surgery, University of Chicago, Chicago, Illinois 60637, United States
Earth and Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States
Kewalo Marine Laboratory, University of Hawaii-Manoa, Honolulu, Hawaii 96813, United States
Center for Marine Cytometry, Concrete, Washington 98237, United States, Instituto Milenio de Oceanografía, Universidad de Concepción, Concepción, Chile

Here, the microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. Moreover, these technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: OBER; PNNL - DE-AC06-76RL01830; AC05-76RL01830

OSTI ID:: 1233975

Alternate ID(s):: OSTI ID: 1237801

Report Number(s):: PNNL-SA-115178

Journal Information:: ACS Nano, Journal Name: ACS Nano Vol. 10 Journal Issue: 1; ISSN 1936-0851

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 102 works

Citation information provided by
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