Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity

Hunter, Michael A.; Coffman, Brian A.; Gasparovic, Charles; Calhoun, Vince D.; Trumbo, Michael C.; Clark, Vincent P.

doi:10.1016/j.brainres.2014.09.066

Title: Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity

Journal Article · Sun Oct 12 00:00:00 EDT 2014 · Brain Research

DOI:https://doi.org/10.1016/j.brainres.2014.09.066· OSTI ID:1344389

Hunter, Michael A. ^[1]; Coffman, Brian A. ^[2]; Gasparovic, Charles ^[3]; Calhoun, Vince D. ^[4]; Trumbo, Michael C. ^[2]; Clark, Vincent P. ^[2]

The Univ. of New Mexico, Albuquerque, NM (United States); The Mind Research Network, Albuquerque, NM (United States); The Univ. of New Mexico School of Medicine, Albuquerque, NM (United States)
The Univ. of New Mexico, Albuquerque, NM (United States); The Mind Research Network, Albuquerque, NM (United States)
The Mind Research Network, Albuquerque, NM (United States)
The Mind Research Network, Albuquerque, NM (United States); The Univ. of New Mexico School of Medicine, Albuquerque, NM (United States); The Univ. of New Mexico, Albuquerque, NM (United States)

Transcranial direct current stimulation (tDCS) modulates glutamatergic neurotransmission and can be utilized as a novel treatment intervention for a multitude of populations. However, the exact mechanism by which tDCS modulates the brain's neural architecture, from the micro to macro scales, have yet to be investigated. In this paper, using a within-subjects design, resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy (¹H MRS) were performed immediately before and after the administration of anodal tDCS over right parietal cortex. Group independent component analysis (ICA) was used to decompose fMRI scans into 75 brain networks, from which 12 resting-state networks were identified that had significant voxel-wise functional connectivity to anatomical regions of interest. ¹H MRS was used to obtain estimates of combined glutamate and glutamine (Glx) concentrations from bilateral intraparietal sulcus. Paired sample t-tests showed significantly increased Glx under the anodal electrode, but not in homologous regions of the contralateral hemisphere. Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal–parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p<0.05, FDR-corrected). Individual differences in Glx concentrations predicted network connectivity in most of these networks. Finally, the observed relationships between glutamatergic neurotransmission and network connectivity may be used to guide future tDCS protocols that aim to target and alter neuroplastic mechanisms in healthy individuals as well as those with psychiatric and neurologic disorders.

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Research Organization:: Univ. of New Mexico, Albuquerque, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Science Foundation (NSF)

Grant/Contract Number:: FG02-99ER62764; P20GM103472; R01EB005846; R01EB006841

OSTI ID:: 1344389

Alternate ID(s):: OSTI ID: 1233904

Journal Information:: Brain Research, Vol. 1594; ISSN 0006-8993

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 81 works

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References (110)

Polarity-specific effects of motor transcranial direct current stimulation on fMRI resting state networks Amadi, Ugwechi; Ilie, Andrei; Johansen-Berg, Heidi NeuroImage, Vol. 88 https://doi.org/10.1016/j.neuroimage.2013.11.037	journal	March 2014
Correlations between measures of executive attention and cortical thickness of left posterior middle frontal gyrus - a dichotic listening study Andersson, Martin; Ystad, Martin; Lundervold, Arvid Behavioral and Brain Functions, Vol. 5, Issue 1 https://doi.org/10.1186/1744-9081-5-41	journal	January 2009
A Common Network of Functional Areas for Attention and Eye Movements Corbetta, Maurizio; Akbudak, Erbil; Conturo, Thomas E. Neuron, Vol. 21, Issue 4 https://doi.org/10.1016/S0896-6273(00)80593-0	journal	October 1998
Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans: Effect of tDCS on cortical excitability Batsikadze, G.; Moliadze, V.; Paulus, W. The Journal of Physiology, Vol. 591, Issue 7 https://doi.org/10.1113/jphysiol.2012.249730	journal	February 2013
Investigations into resting-state connectivity using independent component analysis Beckmann, Christian F.; DeLuca, Marilena; Devlin, Joseph T. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 360, Issue 1457 https://doi.org/10.1098/rstb.2005.1634	journal	May 2005
An Information-Maximization Approach to Blind Separation and Blind Deconvolution Bell, Anthony J.; Sejnowski, Terrence J. Neural Computation, Vol. 7, Issue 6 https://doi.org/10.1162/neco.1995.7.6.1129	journal	November 1995
Resting state cortico-cerebellar functional connectivity networks: a comparison of anatomical and self-organizing map approaches Bernard, Jessica A.; Seidler, Rachael D.; Hassevoort, Kelsey M. Frontiers in Neuroanatomy, Vol. 6 https://doi.org/10.3389/fnana.2012.00031	journal	January 2012
Functional connectivity in the motor cortex of resting human brain using echo-planar mri Biswal, Bharat; Zerrin Yetkin, F.; Haughton, Victor M. Magnetic Resonance in Medicine, Vol. 34, Issue 4 https://doi.org/10.1002/mrm.1910340409	journal	October 1995
A synaptic model of memory: long-term potentiation in the hippocampus Bliss, T. V. P.; Collingridge, G. L. Nature, Vol. 361, Issue 6407 https://doi.org/10.1038/361031a0	journal	January 1993
The Role of the Corpus Callosum in Interhemispheric Transfer of Information: Excitation or Inhibition? Bloom, Juliana S.; Hynd, George W. Neuropsychology Review, Vol. 15, Issue 2 https://doi.org/10.1007/s11065-005-6252-y	journal	June 2005
Enhancing multisensory spatial orienting by brain polarization of the parietal cortex: A transcranial direct current stimulation study of multisensory processing Bolognini, Nadia; Olgiati, Elena; Rossetti, Angela European Journal of Neuroscience, Vol. 31, Issue 10 https://doi.org/10.1111/j.1460-9568.2010.07211.x	journal	May 2010
Salience network integrity predicts default mode network function after traumatic brain injury Bonnelle, V.; Ham, T. E.; Leech, R. Proceedings of the National Academy of Sciences, Vol. 109, Issue 12 https://doi.org/10.1073/pnas.1113455109	journal	March 2012
Does glutamate image your thoughts? Bonvento, Gilles; Sibson, Nicola; Pellerin, Luc Trends in Neurosciences, Vol. 25, Issue 7 https://doi.org/10.1016/S0166-2236(02)02168-9	journal	July 2002
The basal ganglia communicate with the cerebellum Bostan, A. C.; Dum, R. P.; Strick, P. L. Proceedings of the National Academy of Sciences, Vol. 107, Issue 18 https://doi.org/10.1073/pnas.1000496107	journal	April 2010
The organization of the human cerebellum estimated by intrinsic functional connectivity Buckner, Randy L.; Krienen, Fenna M.; Castellanos, Angela Journal of Neurophysiology, Vol. 106, Issue 5 https://doi.org/10.1152/jn.00339.2011	journal	November 2011
Multisubject Independent Component Analysis of fMRI: A Decade of Intrinsic Networks, Default Mode, and Neurodiagnostic Discovery Calhoun, Vince D.; Adali, Tülay IEEE Reviews in Biomedical Engineering, Vol. 5 https://doi.org/10.1109/RBME.2012.2211076	journal	January 2012
A method for making group inferences from functional MRI data using independent component analysis Calhoun, V. D.; Adali, T.; Pearlson, G. D. Human Brain Mapping, Vol. 14, Issue 3 https://doi.org/10.1002/hbm.1048	journal	January 2001
Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder Cao, Xiaohua; Cao, Qingjiu; Long, Xiangyu Brain Research, Vol. 1303 https://doi.org/10.1016/j.brainres.2009.08.029	journal	November 2009
The organization of the human striatum estimated by intrinsic functional connectivity Choi, Eun Young; Yeo, B. T. Thomas; Buckner, Randy L. Journal of Neurophysiology, Vol. 108, Issue 8 https://doi.org/10.1152/jn.00270.2012	journal	October 2012
Topological FDR for neuroimaging Chumbley, J.; Worsley, K.; Flandin, G. NeuroImage, Vol. 49, Issue 4 https://doi.org/10.1016/j.neuroimage.2009.10.090	journal	February 2010
False discovery rate revisited: FDR and topological inference using Gaussian random fields Chumbley, J.; Friston, K. NeuroImage, Vol. 44, Issue 1 https://doi.org/10.1016/j.neuroimage.2008.05.021	journal	January 2009
TDCS guided using fMRI significantly accelerates learning to identify concealed objects Clark, Vincent P.; Coffman, Brian A.; Mayer, Andy R. NeuroImage, Vol. 59, Issue 1 https://doi.org/10.1016/j.neuroimage.2010.11.036	journal	January 2012
Transcranial direct current stimulation (tDCS) produces localized and specific alterations in neurochemistry: A 1H magnetic resonance spectroscopy study Clark, Vincent P.; Coffman, Brian A.; Trumbo, Michael C. Neuroscience Letters, Vol. 500, Issue 1 https://doi.org/10.1016/j.neulet.2011.05.244	journal	August 2011
Influence of Anodal Transcranial Direct Current Stimulation (tDCS) over the Right Angular Gyrus on Brain Activity during Rest Clemens, Benjamin; Jung, Stefanie; Mingoia, Gianluca PLoS ONE, Vol. 9, Issue 4 https://doi.org/10.1371/journal.pone.0095984	journal	April 2014
Basal Ganglia and Cerebellar Inputs to ‘AIP’ Clower, Dottie M.; Dum, Richard P.; Strick, Peter L. Cerebral Cortex, Vol. 15, Issue 7 https://doi.org/10.1093/cercor/bhh190	journal	September 2004
The Reorienting System of the Human Brain: From Environment to Theory of Mind Corbetta, Maurizio; Patel, Gaurav; Shulman, Gordon L. Neuron, Vol. 58, Issue 3 https://doi.org/10.1016/j.neuron.2008.04.017	journal	May 2008
Interhemispheric imbalance during visuospatial attention investigated by unilateral and bilateral TMS over human parietal cortices Dambeck, Nina; Sparing, Roland; Meister, Ingo G. Brain Research, Vol. 1072, Issue 1 https://doi.org/10.1016/j.brainres.2005.05.075	journal	February 2006
Transcranial direct current stimulation applied over the somatosensory cortex – Differential effect on low and high frequency SEPs Dieckhöfer, Anne; Waberski, Till Dino; Nitsche, Michael Clinical Neurophysiology, Vol. 117, Issue 10 https://doi.org/10.1016/j.clinph.2006.07.136	journal	October 2006
Baseline GABA concentration and fMRI response Donahue, Manus J.; Near, Jamie; Blicher, Jakob U. NeuroImage, Vol. 53, Issue 2 https://doi.org/10.1016/j.neuroimage.2010.07.017	journal	November 2010
What are the computations of the cerebellum, the basal ganglia and the cerebral cortex? Doya, K. Neural Networks, Vol. 12, Issue 7-8 https://doi.org/10.1016/S0893-6080(99)00046-5	journal	October 1999
Involvement of glutamate in rest-stimulus interaction between perigenual and supragenual anterior cingulate cortex: A combined fMRI-MRS study Duncan, Niall W.; Enzi, Björn; Wiebking, Christine Human Brain Mapping, Vol. 32, Issue 12 https://doi.org/10.1002/hbm.21179	journal	February 2011
E-I balance and human diseases – from molecules to networking Eichler, Sabrina A. Frontiers in Molecular Neuroscience, Vol. 1 https://doi.org/10.3389/neuro.02.002.2008	journal	January 2008
Glutamate modulates resting state activity in the perigenual anterior cingulate cortex – A combined fMRI–MRS study Enzi, B.; Duncan, N. W.; Kaufmann, J. Neuroscience, Vol. 227 https://doi.org/10.1016/j.neuroscience.2012.09.039	journal	December 2012
On Network Derivation, Classification, and Visualization: A Response to Habeck and Moeller Erhardt, Erik B.; Allen, Elena A.; Damaraju, Eswar Brain Connectivity, Vol. 1, Issue 2 https://doi.org/10.1089/brain.2011.0022	journal	August 2011
Paradoxical Facilitation of Attention in Healthy Humans Fecteau, Shirley; Pascual-Leone, Alvaro; Théoret, Hugo Behavioural Neurology, Vol. 17, Issue 3-4 https://doi.org/10.1155/2006/632141	journal	January 2006
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging Fox, Michael D.; Raichle, Marcus E. Nature Reviews Neuroscience, Vol. 8, Issue 9 https://doi.org/10.1038/nrn2201	journal	September 2007
Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex Fricke, K.; Seeber, A. A.; Thirugnanasambandam, N. Journal of Neurophysiology, Vol. 105, Issue 3 https://doi.org/10.1152/jn.00608.2009	journal	March 2011
The disconnection hypothesis Friston, Karl J. Schizophrenia Research, Vol. 30, Issue 2 https://doi.org/10.1016/S0920-9964(97)00140-0	journal	March 1998
Modulation of Cerebellar Excitability by Polarity-Specific Noninvasive Direct Current Stimulation Galea, J. M.; Jayaram, G.; Ajagbe, L. Journal of Neuroscience, Vol. 29, Issue 28 https://doi.org/10.1523/JNEUROSCI.2184-09.2009	journal	July 2009
Cortical Regulation of Striatal Medium Spiny Neuron Dendritic Remodeling in Parkinsonism: Modulation of Glutamate Release Reverses Dopamine Depletion–Induced Dendritic Spine Loss Garcia, Bonnie G.; Neely, M. Diana; Deutch, Ariel Y. Cerebral Cortex, Vol. 20, Issue 10 https://doi.org/10.1093/cercor/bhp317	journal	January 2010
Neurometabolite Concentrations in Gray and White Matter in Mild Traumatic Brain Injury: An ¹ H–Magnetic Resonance Spectroscopy Study Gasparovic, Charles; Yeo, Ronald; Mannell, Maggie Journal of Neurotrauma, Vol. 26, Issue 10 https://doi.org/10.1089/neu.2009.0896	journal	October 2009
Integrating Neurotransmission in Striatal Medium Spiny Neurons Girault, Jean-Antoine Synaptic Plasticity https://doi.org/10.1007/978-3-7091-0932-8_18	book	January 2012
Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Greicius, M. D.; Krasnow, B.; Reiss, A. L. Proceedings of the National Academy of Sciences, Vol. 100, Issue 1 https://doi.org/10.1073/pnas.0135058100	journal	December 2002
A mathematical model of compartmentalized neurotransmitter metabolism in the human brain Gruetter, Rolf; Seaquist, Elizabeth R.; Ugurbil, Kâmil American Journal of Physiology-Endocrinology and Metabolism, Vol. 281, Issue 1 https://doi.org/10.1152/ajpendo.2001.281.1.E100	journal	July 2001
Distinct Cerebellar Contributions to Intrinsic Connectivity Networks Habas, C.; Kamdar, N.; Nguyen, D. Journal of Neuroscience, Vol. 29, Issue 26 https://doi.org/10.1523/JNEUROSCI.1868-09.2009	journal	July 2009
The primate basal ganglia: parallel and integrative networks Haber, Suzanne N. Journal of Chemical Neuroanatomy, Vol. 26, Issue 4 https://doi.org/10.1016/j.jchemneu.2003.10.003	journal	December 2003
Cognitive Control and the Salience Network: An Investigation of Error Processing and Effective Connectivity Ham, T.; Leff, A.; de Boissezon, X. Journal of Neuroscience, Vol. 33, Issue 16 https://doi.org/10.1523/JNEUROSCI.4692-12.2013	journal	April 2013
Validating the independent components of neuroimaging time series via clustering and visualization Himberg, Johan; Hyvärinen, Aapo; Esposito, Fabrizio NeuroImage, Vol. 22, Issue 3 https://doi.org/10.1016/j.neuroimage.2004.03.027	journal	July 2004
Action selection and refinement in subcortical loops through basal ganglia and cerebellum Houk, J. C.; Bastianen, C.; Fansler, D. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 362, Issue 1485 https://doi.org/10.1098/rstb.2007.2063	journal	April 2007
Human cerebellar activity reflecting an acquired internal model of a new tool Imamizu, Hiroshi; Miyauchi, Satoru; Tamada, Tomoe Nature, Vol. 403, Issue 6766 https://doi.org/10.1038/35003194	journal	January 2000
A method for functional network connectivity among spatially independent resting-state components in schizophrenia Jafri, Madiha J.; Pearlson, Godfrey D.; Stevens, Michael NeuroImage, Vol. 39, Issue 4 https://doi.org/10.1016/j.neuroimage.2007.11.001	journal	February 2008
Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network Kapogiannis, Dimitrios; Reiter, David A.; Willette, Auriel A. NeuroImage, Vol. 64 https://doi.org/10.1016/j.neuroimage.2012.09.029	journal	January 2013
The Dynamic Brain: Neuroplasticity and Mental Health Kays, Jill L.; Hurley, Robin A.; Taber, Katherine H. The Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 24, Issue 2 https://doi.org/10.1176/appi.neuropsych.12050109	journal	January 2012
Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI Keeser, D.; Meindl, T.; Bor, J. Journal of Neuroscience, Vol. 31, Issue 43 https://doi.org/10.1523/JNEUROSCI.0542-11.2011	journal	October 2011
ICA-fNORM: Spatial Normalization of fMRI Data Using Intrinsic Group-ICA Networks Khullar, Siddharth; Michael, Andrew M.; Cahill, Nathan D. Frontiers in Systems Neuroscience, Vol. 5 https://doi.org/10.3389/fnsys.2011.00093	journal	January 2011
Medial Prefrontal and Subcortical Mechanisms Underlying the Acquisition of Motor and Cognitive Action Sequences in Humans Koechlin, Etienne; Danek, Adrian; Burnod, Yves Neuron, Vol. 35, Issue 2 https://doi.org/10.1016/S0896-6273(02)00742-0	journal	July 2002
Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability Liebetanz, D. Brain, Vol. 125, Issue 10 https://doi.org/10.1093/brain/awf238	journal	October 2002
A Neuronal Basis for Task-Negative Responses in the Human Brain Lin, Pan; Hasson, Uri; Jovicich, Jorge Cerebral Cortex, Vol. 21, Issue 4 https://doi.org/10.1093/cercor/bhq151	journal	August 2010
Targeting Glutamatergic Signaling for the Development of Novel Therapeutics for Mood Disorders Machado-Vieira, Rodrigo; Salvadore, Giacomo; Ibrahim, Lobna Current Pharmaceutical Design, Vol. 15, Issue 14 https://doi.org/10.2174/138161209788168010	journal	May 2009
Functional Connectivity of Human Striatum: A Resting State fMRI Study Di Martino, A.; Scheres, A.; Margulies, D. S. Cerebral Cortex, Vol. 18, Issue 12 https://doi.org/10.1093/cercor/bhn041	journal	April 2008
Analysis of fMRI data by blind separation into independent spatial components Mckeown, Martin J.; Makeig, Scott; Brown, Greg G. Human Brain Mapping, Vol. 6, Issue 3 https://doi.org/10.1002/(SICI)1097-0193(1998)6:3<160::AID-HBM5>3.0.CO;2-1	journal	January 1998
Neurobiological Effects of Transcranial Direct Current Stimulation: A Review Medeiros, Liciane Fernandes; de Souza, Izabel Cristina Custodio; Vidor, Liliane Pinto Frontiers in Psychiatry, Vol. 3 https://doi.org/10.3389/fpsyt.2012.00110	journal	January 2012
Saliency, switching, attention and control: a network model of insula function Menon, Vinod; Uddin, Lucina Q. Brain Structure and Function, Vol. 214, Issue 5-6 https://doi.org/10.1007/s00429-010-0262-0	journal	May 2010
Disruption of State Estimation in the Human Lateral Cerebellum Miall, R. Chris; Christensen, Lars O. D.; Cain, Owen PLoS Biology, Vol. 5, Issue 11 https://doi.org/10.1371/journal.pbio.0050316	journal	November 2007
Remapping Attentional Priorities: Differential Contribution of Superior Parietal Lobule and Intraparietal Sulcus Molenberghs, P.; Mesulam, M. M.; Peeters, R. Cerebral Cortex, Vol. 17, Issue 11 https://doi.org/10.1093/cercor/bhl179	journal	January 2007
Modulation of Top-Down Control of Visual Attention by Cathodal tDCS over Right IPS Moos, K.; Vossel, S.; Weidner, R. Journal of Neuroscience, Vol. 32, Issue 46 https://doi.org/10.1523/JNEUROSCI.6233-11.2012	journal	November 2012
Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition Muthukumaraswamy, Suresh D.; Evans, C. John; Edden, Richard A. E. Human Brain Mapping, Vol. 33, Issue 2 https://doi.org/10.1002/hbm.21223	journal	March 2011
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation Nitsche, M. A.; Paulus, W. The Journal of Physiology, Vol. 527, Issue 3 https://doi.org/10.1111/j.1469-7793.2000.t01-1-00633.x	journal	September 2000
GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans Nitsche, Michael A.; Liebetanz, David; Schlitterlau, Anett European Journal of Neuroscience, Vol. 19, Issue 10 https://doi.org/10.1111/j.0953-816X.2004.03398.x	journal	May 2004
Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex: Cortical excitability and tDCS Nitsche, Michael A.; Seeber, Antje; Frommann, Kai The Journal of Physiology, Vol. 568, Issue 1 https://doi.org/10.1113/jphysiol.2005.092429	journal	September 2005
GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI Northoff, Georg; Walter, Martin; Schulte, Rolf F. Nature Neuroscience, Vol. 10, Issue 12 https://doi.org/10.1038/nn2001	journal	November 2007
Distinct and Overlapping Functional Zones in the Cerebellum Defined by Resting State Functional Connectivity O'Reilly, Jill X.; Beckmann, Christian F.; Tomassini, Valentina Cerebral Cortex, Vol. 20, Issue 4 https://doi.org/10.1093/cercor/bhp157	journal	August 2009
Transcranial direct current stimulation increases resting state interhemispheric connectivity Park, Chang-hyun; Chang, Won Hyuk; Park, Ji-Young Neuroscience Letters, Vol. 539 https://doi.org/10.1016/j.neulet.2013.01.047	journal	February 2013
From plasticity to complexity: a new diagnostic method for psychiatry Peled, Avi Medical Hypotheses, Vol. 63, Issue 1 https://doi.org/10.1016/j.mehy.2004.02.010	journal	January 2004
Plasticity imbalance in mental disorders the neuroscience of psychiatry: Implications for diagnosis and research Peled, Avi Medical Hypotheses, Vol. 65, Issue 5 https://doi.org/10.1016/j.mehy.2005.05.007	journal	January 2005
Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI Peña-Gómez, Cleofé; Sala-Lonch, Roser; Junqué, Carme Brain Stimulation, Vol. 5, Issue 3 https://doi.org/10.1016/j.brs.2011.08.006	journal	July 2012
Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation Polanía, Rafael; Paulus, Walter; Nitsche, Michael A. Human Brain Mapping, Vol. 33, Issue 10 https://doi.org/10.1002/hbm.21380	journal	September 2011
Introducing graph theory to track for neuroplastic alterations in the resting human brain: A transcranial direct current stimulation study Polanía, Rafael; Paulus, Walter; Antal, Andrea NeuroImage, Vol. 54, Issue 3 https://doi.org/10.1016/j.neuroimage.2010.09.085	journal	February 2011
Evidence for Hubs in Human Functional Brain Networks Power, Jonathan D.; Schlaggar, Bradley L.; Lessov-Schlaggar, Christina N. Neuron, Vol. 79, Issue 4 https://doi.org/10.1016/j.neuron.2013.07.035	journal	August 2013
Automatic quantitation of localizedin vivo1H spectra with LCModel Provencher, Stephen W. NMR in Biomedicine, Vol. 14, Issue 4 https://doi.org/10.1002/nbm.698	journal	January 2001
Role of cortical cell type and morphology in subthreshold and suprathreshold uniform electric field stimulation in vitro Radman, Thomas; Ramos, Raddy L.; Brumberg, Joshua C. Brain Stimulation, Vol. 2, Issue 4 https://doi.org/10.1016/j.brs.2009.03.007	journal	October 2009
A default mode of brain function: A brief history of an evolving idea Raichle, Marcus E.; Snyder, Abraham Z. NeuroImage, Vol. 37, Issue 4 https://doi.org/10.1016/j.neuroimage.2007.02.041	journal	October 2007
A default mode of brain function Raichle, M. E.; MacLeod, A. M.; Snyder, A. Z. Proceedings of the National Academy of Sciences, Vol. 98, Issue 2 https://doi.org/10.1073/pnas.98.2.676	journal	January 2001
Myoinositol content in the human brain is modified by transcranial direct current stimulation in a matter of minutes: A ¹ H-MRS study Rango, M.; Cogiamanian, F.; Marceglia, S. Magnetic Resonance in Medicine, Vol. 60, Issue 4 https://doi.org/10.1002/mrm.21709	journal	October 2008
Attention Systems and the Organization of the Human Parietal Cortex Rushworth, M. F. S.; Paus, T.; Sipila, P. K. The Journal of Neuroscience, Vol. 21, Issue 14 https://doi.org/10.1523/JNEUROSCI.21-14-05262.2001	journal	July 2001
The cerebellar cognitive affective syndrome Schmahmann, J. Brain, Vol. 121, Issue 4 https://doi.org/10.1093/brain/121.4.561	journal	April 1998
Cognition, emotion and the cerebellum Schmahmann, Jeremy D.; Caplan, David Brain, Vol. 129, Issue 2 https://doi.org/10.1093/brain/awh729	journal	February 2006
Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control Seeley, W. W.; Menon, V.; Schatzberg, A. F. Journal of Neuroscience, Vol. 27, Issue 9 https://doi.org/10.1523/JNEUROSCI.5587-06.2007	journal	February 2007
Dynamic modulation of intrinsic functional connectivity by transcranial direct current stimulation Sehm, Bernhard; Schäfer, Alexander; Kipping, Judy Journal of Neurophysiology, Vol. 108, Issue 12 https://doi.org/10.1152/jn.00606.2012	journal	December 2012
State-Dependency of Transcranial Magnetic Stimulation Silvanto, Juha; Pascual-Leone, Alvaro Brain Topography, Vol. 21, Issue 1 https://doi.org/10.1007/s10548-008-0067-0	journal	September 2008
A common role of insula in feelings, empathy and uncertainty Singer, Tania; Critchley, Hugo D.; Preuschoff, Kerstin Trends in Cognitive Sciences, Vol. 13, Issue 8 https://doi.org/10.1016/j.tics.2009.05.001	journal	August 2009
Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach Skudlarski, Pawel; Jagannathan, Kanchana; Anderson, Karen Biological Psychiatry, Vol. 68, Issue 1 https://doi.org/10.1016/j.biopsych.2010.03.035	journal	July 2010
Brain plasticity and pathology in psychiatric disease: sites of action for potential therapy Spedding, M.; Neau, I.; Harsing, L. Current Opinion in Pharmacology, Vol. 3, Issue 1 https://doi.org/10.1016/S1471-4892(02)00008-5	journal	February 2003
A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks Sridharan, D.; Levitin, D. J.; Menon, V. Proceedings of the National Academy of Sciences, Vol. 105, Issue 34 https://doi.org/10.1073/pnas.0800005105	journal	August 2008
Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation Stagg, C. J.; Best, J. G.; Stephenson, M. C. Journal of Neuroscience, Vol. 29, Issue 16 https://doi.org/10.1523/JNEUROSCI.4432-08.2009	journal	April 2009
Measurement of Brain Metabolites by 1H Magnetic Resonance Spectroscopy in Patients with Schizophrenia: A Systematic Review and Meta-Analysis Steen, R. Grant; Hamer, Robert M.; Lieberman, Jeffrey A. Neuropsychopharmacology, Vol. 30, Issue 11 https://doi.org/10.1038/sj.npp.1300850	journal	August 2005
Synaptic Plasticity and Dysconnection in Schizophrenia Stephan, Klaas E.; Baldeweg, Torsten; Friston, Karl J. Biological Psychiatry, Vol. 59, Issue 10 https://doi.org/10.1016/j.biopsych.2005.10.005	journal	May 2006
Anterior Prefrontal Cortex Mediates Rule Learning in Humans Strange, B. A. Cerebral Cortex, Vol. 11, Issue 11 https://doi.org/10.1093/cercor/11.11.1040	journal	November 2001
Proton magnetic resonance spectroscopy measures related to short-term symptomatic outcome in chronic schizophrenia Szulc, Agata; Konarzewska, Beata; Galinska-Skok, Beata Neuroscience Letters, Vol. 547 https://doi.org/10.1016/j.neulet.2013.04.051	journal	June 2013
Salience Network–Based Classification and Prediction of Symptom Severity in Children With Autism Uddin, Lucina Q.; Supekar, Kaustubh; Lynch, Charles J. JAMA Psychiatry, Vol. 70, Issue 8 https://doi.org/10.1001/jamapsychiatry.2013.104	journal	August 2013
Exploring the brain network: A review on resting-state fMRI functional connectivity van den Heuvel, Martijn P.; Hulshoff Pol, Hilleke E. European Neuropsychopharmacology, Vol. 20, Issue 8 https://doi.org/10.1016/j.euroneuro.2010.03.008	journal	August 2010
Parcellation of parietal cortex: Convergence between lesion-symptom mapping and mapping of the intact functioning brain Vandenberghe, Rik; Gillebert, Céline R. Behavioural Brain Research, Vol. 199, Issue 2 https://doi.org/10.1016/j.bbr.2008.12.005	journal	May 2009
Combining transcranial direct current stimulation and neuroimaging: novel insights in understanding neuroplasticity Venkatakrishnan, Anusha; Sandrini, Marco Journal of Neurophysiology, Vol. 107, Issue 1 https://doi.org/10.1152/jn.00557.2011	journal	January 2012
The Relationship Between Aberrant Neuronal Activation in the Pregenual Anterior Cingulate, Altered Glutamatergic Metabolism, and Anhedonia in Major Depression Walter, Martin; Henning, Anke; Grimm, Simone Archives of General Psychiatry, Vol. 66, Issue 5 https://doi.org/10.1001/archgenpsychiatry.2009.39	journal	May 2009
Aberrant salience network (bilateral insula and anterior cingulate cortex) connectivity during information processing in schizophrenia White, Thomas P.; Joseph, Verghese; Francis, Susan T. Schizophrenia Research, Vol. 123, Issue 2-3 https://doi.org/10.1016/j.schres.2010.07.020	journal	November 2010
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation Whittington, Miles A.; Traub, Roger D.; Jefferys, John G. R. Nature, Vol. 373, Issue 6515 https://doi.org/10.1038/373612a0	journal	February 1995
A framework for interpreting functional networks in schizophrenia Williamson, Peter C.; Allman, John M. Frontiers in Human Neuroscience, Vol. 6 https://doi.org/10.3389/fnhum.2012.00184	journal	January 2012
PREMOTOR AND PARIETAL CORTEX: Corticocortical Connectivity and Combinatorial Computations Wise, Steven P.; Boussaoud, Driss; Johnson, Paul B. Annual Review of Neuroscience, Vol. 20, Issue 1 https://doi.org/10.1146/annurev.neuro.20.1.25	journal	March 1997
Functional significance of individual variations in callosal area Yazgan, M. Yanki; Wexler, Bruce E.; Kinsbourne, Marcel Neuropsychologia, Vol. 33, Issue 6 https://doi.org/10.1016/0028-3932(95)00018-X	journal	June 1995
Resolution of Uncertainty in Prefrontal Cortex Yoshida, Wako; Ishii, Shin Neuron, Vol. 50, Issue 5 https://doi.org/10.1016/j.neuron.2006.05.006	journal	June 2006

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