skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structure-Based Functional Characterization of Repressor of Toxin (Rot), a Central Regulator of Staphylococcus aureus Virulence

Journal Article · · Journal of Bacteriology
DOI:https://doi.org/10.1128/JB.02317-14· OSTI ID:1229412

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
DOE Contract Number:
SC00112704
OSTI ID:
1229412
Report Number(s):
BNL-111488-2015-JA
Journal Information:
Journal of Bacteriology, Vol. 197, Issue 1; ISSN 0021-9193
Publisher:
American Society for Microbiology
Country of Publication:
United States
Language:
English

References (52)

Staphylococcus aureus Infections journal August 1998
Survey of Infections Due to Staphylococcus Species: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999 journal May 2001
Global Epidemiology of Antimicrobial Resistance among Community-Acquired and Nosocomial Pathogens: A Five-Year Summary from the SENTRY Antimicrobial Surveillance Program (1997-2001) journal January 2003
Methicillin-Resistant Staphylococcus aureus Disease in Three Communities journal April 2005
Community-associated meticillin-resistant Staphylococcus aureus journal May 2010
Invasive Methicillin-Resistant <EMPH TYPE="ITAL">Staphylococcus aureus</EMPH> Infections in the United States journal October 2007
Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin journal December 1997
QUORUM SENSING: Cell-to-Cell Communication in Bacteria journal November 2005
Quorum Sensing in Staphylococci journal December 2008
Regulation of exoprotein gene expression in Staphylococcus aureus by agr journal January 1986
RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus journal October 2008
Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus journal November 1989
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. journal October 1993
Probing the structure of RNAIII, the Staphylococcus aureus agr regulatory RNA, and identification of the RNA domain involved in repression of protein A expression journal May 2000
Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism journal June 2007
Inhibition of rot translation by RNAIII, a key feature of agr function journal August 2006
Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression journal January 2005
Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII. journal September 1995
Identification, Cloning, and Initial Characterization of rot, a Locus Encoding a Regulator of Virulence Factor Expression in Staphylococcus aureus journal June 2000
Global Regulation of Staphylococcus aureus Genes by Rot journal January 2003
Autoinduction and signal transduction in the regulation of staphylococcal virulence: Regulation of staphylococcus virulence journal May 2003
A rot Mutation Restores Parental Virulence to an agr-Null Staphylococcus aureus Strain in a Rabbit Model of Endocarditis journal June 2005
Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo: LukED contributes to S. aureus bacteraemia journal December 2011
Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner: Rot positively regulates Ssls in S. aureus journal June 2011
Rot Repression of Enterotoxin B Expression in Staphylococcus aureus journal August 2005
The winged-helix DNA-binding motif: Another helix-turn-helix takeoff journal September 1993
The molecular basis of DNA–protein recognition inferred from the structure of cro repressor journal August 1982
Many gene-regulatory proteins appear to have a similar α-helical fold that binds DNA and evolved from a common precursor journal March 1983
Homology among DNA-binding proteins suggests use of a conserved super-secondary structure journal July 1982
Rot and SaeRS Cooperate To Activate Expression of the Staphylococcal Superantigen-Like Exoproteins journal June 2012
Overview of the CCP 4 suite and current developments journal March 2011
The CCP4 suite programs for protein crystallography journal September 1994
Experimental phasing with SHELXC / D / E : combining chain tracing with density modification journal March 2010
The Buccaneer software for automated model building. 1. Tracing protein chains journal August 2006
Features and development of Coot journal March 2010
REFMAC 5 for the refinement of macromolecular crystal structures journal March 2011
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation journal May 1994
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
Structure of an OhrR-ohrA Operator Complex Reveals the DNA Binding Mechanism of the MarR Family journal October 2005
Soft protein-protein docking in internal coordinates journal February 2002
Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins journal September 2006
Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element: Rot dysregulation in MRSA-USA500 leads to hypervirulence journal July 2014
Structure of Rot, a global regulator of virulence genes in Staphylococcus aureus journal August 2014
Characterization of the SarA virulence gene regulator of Staphylococcus aureus journal July 1999
SarA, a Global Regulator of Virulence Determinants in Staphylococcus aureus , Binds to a Conserved Motif Essential for sar -dependent Gene Regulation journal December 1999
Characterization of Staphylococcus aureus SarA Binding Sites journal August 2003
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids journal May 2010
The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage journal October 1983
Molecular genetics of SaPI1 - a mobile pathogenicity island in Staphylococcus aureus: SaPI1 molecular genetics journal July 2001
Staphylococcal Coagulase: Mode of Action and Antigenicity journal February 1952
Single-copy vectors for integration at the SaPI1 attachment site for Staphylococcus aureus journal November 2014

Cited By (4)

Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus journal July 2019
Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc journal June 2016
High Production of LukMF’ in Staphylococcus aureus Field Strains Is Associated with Clinical Bovine Mastitis journal May 2018
Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus posted_content April 2019

Similar Records

Related Subjects