Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control

Cary, Robert E.

Title: Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control

Patent · Tue Dec 08 00:00:00 EST 2015

OSTI ID:1228041

Cary, Robert E.

Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-06NA25396

Assignee:: Los Alamos National Security, LLC

Patent Number(s):: 9,207,236

Application Number:: 12/940,973

OSTI ID:: 1228041

Resource Relation:: Patent File Date: 2010 Nov 05

Country of Publication:: United States

Language:: English

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