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Title: Bio-corrosion and cytotoxicity studies on novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses

Metallic glasses are a potential and compatible implant candidate for biomedical applications. In the present investigation, a comparative study between novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses is carried out to evaluate in vitro biocompatibility using simulated body fluids. The bio-corrosion behavior of Zr- and Cu-based metallic glasses in different types of artificial body fluids such as artificial saliva solution, phosphate-buffered saline solution, artificial blood plasma solution, and Hank’s balanced saline solution is evaluated using potentiodynamic polarization studies at a constant body temperature of 310.15 K (37 °C). Surface morphology of samples after bio-corrosion experiments was observed by scanning electron microscopy. In vitro cytotoxicity test on glassy alloys were performed using human osteosarcoma cell line as per 10993-5 guidelines from International Organization for Standardization. As a result, the comparative study between Zr- and Cu-based glassy alloys provides vital information about the effect of elemental composition on biocompatibility of metallic glasses.
 [1] ;  [2] ;  [2] ;  [3] ;  [4] ;  [5] ;  [1]
  1. Visvesvaraya National Institute of Technology, Nagour (India)
  2. National Environmental Engineering Research Institute, Nagpur (India)
  3. Ames Lab., Ames, IA (United States)
  4. Iowa State Univ., Ames, IA (United States)
  5. Indian Inst. of Technology (IIT), Madras (India)
Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 1073-5623; PII: 2574
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Metallurgical and Materials Transactions. A, Physical Metallurgy and Materials Science
Additional Journal Information:
Journal Volume: 46; Journal Issue: 6; Journal ID: ISSN 1073-5623
ASM International
Research Org:
Ames Laboratory (AMES), Ames, IA (United States)
Sponsoring Org:
Country of Publication:
United States
36 MATERIALS SCIENCE; 60 APPLIED LIFE SCIENCES glassy alloy; ho cell; metallic glass; artificial saliva solution; ho cell line; artificial body fluid; SBF solution; melt-spun alloy; potentiodynamic polarization; 316L stainless steel; passive film; osteosarcoma cell line; simulated body fluid; corrosion behavior; cell viability