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Title: Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid

Journal Article · · ACS Synthetic Biology

Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1225674
Journal Information:
ACS Synthetic Biology, Journal Name: ACS Synthetic Biology Vol. 5 Journal Issue: 1; ISSN 2161-5063
Publisher:
American Chemical Society (ACS)Copyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 58 works
Citation information provided by
Web of Science

References (24)

Integrated engineering of β-oxidation reversal and ω-oxidation pathways for the synthesis of medium chain ω-functionalized carboxylic acids journal March 2015
A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases journal November 2008
Modular organization of genes required for complex polyketide biosynthesis journal May 1991
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272 journal January 2003
Generation of Multiple Bioactive Macrolides by Hybrid Modular Polyketide Synthases in Streptomyces venezuelae journal February 2002
Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli: Adipic Acid Production From a Synthetic Pathway journal July 2014
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products journal March 1999
Structures and Mechanisms of Polyketide Synthases journal July 2009
An erythromycin analog produced by reprogramming of polyketide synthesis. journal August 1993
Facile Detection of Acyl and Peptidyl Intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions during Tandem Mass Spectrometry journal October 2006
In Vitro Analysis of Carboxyacyl Substrate Tolerance in the Loading and First Extension Modules of Borrelidin Polyketide Synthase journal September 2014
Structure of a modular polyketide synthase journal June 2014
Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase. journal March 1994
Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry journal June 2013
Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond Formation journal April 2011
Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli journal March 2001
Development of new catalysts for N2O-decomposition from adipic acid plant journal January 2007
The 2.7-A crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase journal July 2006
j5 DNA Assembly Design Automation Software journal December 2011
Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform journal December 2014
A Tylosin Ketoreductase Reveals How Chirality Is Determined in Polyketides journal August 2007
Combinatorial biosynthesis of polyketides—a perspective journal April 2012
Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry: Limited proteolysis and MS of modular PKSs journal April 2005
Correlation analysis of targeted proteins and metabolites to assess and engineer microbial isopentenol production: Targeted Proteomics-Based Correlation Analysis journal May 2014

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