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Title: Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Journal Article · · Biochimica et Biophysica Acta. Molecular Basis of Disease
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Sponsoring Organization:
USDOE Energy Information Administration (EIA)
Grant/Contract Number:
0840118N
OSTI ID:
1225101
Journal Information:
Biochimica et Biophysica Acta. Molecular Basis of Disease, Journal Name: Biochimica et Biophysica Acta. Molecular Basis of Disease Vol. 1842 Journal Issue: 11; ISSN 0925-4439
Publisher:
ElsevierCopyright Statement
Country of Publication:
Netherlands
Language:
English
Citation Metrics:
Cited by: 28 works
Citation information provided by
Web of Science

References (57)

Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice journal October 2013
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Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice journal March 2003
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Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid. journal May 1996
Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques: Potential Implications for Inflammation and Plaque Instability journal March 2000
Mast cells associate with neovessels in the media and adventitia of abdominal aortic aneurysms journal August 2009
Reduction of atherosclerosis in mice by inhibition of CD40 signalling journal July 1998
Coronary Plaque Erosion Without Rupture Into a Lipid Core: A Frequent Cause of Coronary Thrombosis in Sudden Coronary Death journal April 1996
Sequence homology between human .alpha.1-antichymotrypsin, .alpha.1-antitrypsin, and antithrombin III journal October 1983
MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices journal May 2005
Additive enhancement of neutrophil collagenase activity by HOCl and cathepsin G journal April 1992
Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. journal April 1993
The Distribution and Chemical Composition of Ultracentrifugally Separated Lipoproteins in Human Serum journal September 1955
Mast cells in vulnerable atherosclerotic plaques – a view to a kill journal July 2007
Normal Neutrophil Function in Cathepsin G-Deficient Mice journal December 1999
Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E–Null Mice journal February 2005
Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. journal November 1995
The renin-angiotensin-aldosterone system: a specific target for hypertension management journal April 1999
Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. journal October 1992
Atherosclerotic plaque rupture – pathologic basis of plaque stability and instability journal February 1999
Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties. journal November 1993
Loss of Matrix Metalloproteinase-9 or Matrix Metalloproteinase-12 Protects Apolipoprotein E–Deficient Mice Against Atherosclerotic Media Destruction but Differentially Affects Plaque Growth journal March 2004
Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components journal August 2009
Proteolysis and fusion of low density lipoprotein particles independently strengthen their binding to exocytosed mast cell granules. journal January 1994
The Elastolytic Activity of Cathepsin G: An Ex Vivo Study with Dermal Elastin journal June 1991
The Interaction of Lipids and Lipoproteins with the Intercellular Matrix of Arterial Tissue: Its Possible Role in Atherogenesis book January 1982
Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins journal April 2014
Inducible binding of bioactive cathepsin G to the cell surface of neutrophils. A novel mechanism for mediating extracellular catalytic activity of cathepsin G. journal December 1995
Neutrophil Cathepsin G Promotes Detachment-induced Cardiomyocyte Apoptosis via a Protease-activated Receptor-independent Mechanism journal June 2003
Studies on inhibition of neutrophil cathepsin G by? 1-antichymotrypsin journal February 1995
Hyperlipidemia and Atherosclerotic Lesion Development in Ldlr-Deficient Mice on a Long-Term High-Fat Diet journal April 2012
Processing and intracellular transport of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937-modulation by brefeldin A, ammonium chloride, and monensin journal January 1994
Lysosomal Cysteine Proteases in Atherosclerosis journal August 2004
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis journal January 2001
Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy journal May 2013
Coronary Plaque Disruption journal August 1995
Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions journal November 2000
Treatment of Hypertension With Renin-Angiotensin System Inhibitors and Renal Dysfunction: A Systematic Review and Meta-Analysis journal January 2012
Studies on the Synthesis and Secretion of Serum Lipoproteins by rat Liver Slices journal October 1960
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves journal January 2006
Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse journal February 2001
Angiotensin II Generation at the Cell Surface of Activated Neutrophils: Novel Cathepsin G-Mediated Catalytic Activity That Is Resistant to Inhibition journal February 1998
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice journal June 2000
Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1 journal February 2009
The human brm protein is cleaved during apoptosis: The role of cathepsin G journal March 2001
Endogenous Angiotensin II Induces Atherosclerotic Plaque Vulnerability and Elicits a Th1 Response in ApoE −/− Mice journal September 2004
Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability journal December 2008
Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid journal March 2001
Interaction of serum lipoproteins and a proteoglycan from bovine aorta. journal August 1981
Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion journal January 2006
The Murine Orthologue of Human Antichymotrypsin: A STRUCTURAL PARADIGM FOR CLADE A3 SERPINS journal September 2005
Serine protease inhibitor A3 in atherosclerosis and aneurysm disease journal May 2012
Degradation of Phospholipid Transfer Protein (PLTP) and PLTP-generated Pre-β-high Density Lipoprotein by Mast Cell Chymase Impairs High Affinity Efflux of Cholesterol from Macrophage Foam Cells journal April 2003
Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 (‘gelatinase’) by human neutrophil elastase and cathepsin G journal June 1989
Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe α1-antitrypsin deficiency journal January 2007
Processes Involved in the Site-Specific Effect of Probucol on Atherosclerosis in Apolipoprotein E Gene Knockout Mice journal August 2005

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