An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry

Van Berkel, Gary J.; Kertesz, Vilmos

doi:10.1002/rcm.7274

Title: An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry

Journal Article · Tue Aug 25 00:00:00 EDT 2015 · Rapid Communications in Mass Spectrometry

DOI:https://doi.org/10.1002/rcm.7274· OSTI ID:1223662

Van Berkel, Gary J. ^[1]; Kertesz, Vilmos ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Organic and Biological Mass Spectrometry Group

RATIONALE: A simple method to introduce unprocessed samples into a solvent for rapid characterization by liquid introduction atmospheric pressure ionization mass spectrometry has been lacking. The continuous flow, self-cleaning open port sampling interface introduced here fills this void. METHODS: The open port sampling interface used a vertically aligned, co-axial tube arrangement enabling solvent delivery to the sampling end of the device through the tubing annulus and solvent aspiration down the center tube and into the mass spectrometer ionization source via the commercial APCI emitter probe. The solvent delivery rate to the interface was set to exceed the aspiration rate creating a continuous sampling interface along with a constant, self-cleaning spillover of solvent from the top of the probe. RESULTS: Using the open port sampling interface with positive ion mode APCI and a hybrid quadrupole time of flight mass spectrometer, rapid, direct sampling and analysis possibilities are exemplified with plastics, ballpoint and felt tip ink pens, skin, and vegetable oils. These results demonstrated that the open port sampling interface could be used as a simple, versatile and self-cleaning system to rapidly introduce multiple types of unprocessed, sometimes highly concentrated and complex, samples into a solvent flow stream for subsequent ionization and analysis by mass spectrometry. The basic setup presented here could be incorporated with any self-aspirating liquid introduction ionization source (e.g., ESI, APCI, APPI, ICP, etc.) or any type of atmospheric pressure sampling ready mass spectrometer system. CONCLUSIONS: The open port sampling interface provides a means to introduce and quickly analyze unprocessed solid or liquid samples with liquid introduction atmospheric pressure ionization source without fear of sampling interface or ionization source contamination.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1223662

Journal Information:: Rapid Communications in Mass Spectrometry, Vol. 29, Issue 19; ISSN 0951-4198

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

Citation Metrics:

Cited by: 54 works

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References (53)

Sampling reliability, spatial resolution, spatial precision, and extraction efficiency in droplet-based liquid microjunction surface sampling: Basics of LMJ/HPLC/MS/MS sampling Kertesz, Vilmos; Van Berkel, Gary J. Rapid Communications in Mass Spectrometry, Vol. 28, Issue 13 https://doi.org/10.1002/rcm.6931	journal	May 2014
Infrared Laser Ablation Sample Transfer for MALDI and Electrospray Park, Sung-Gun; Murray, Kermit King Journal of The American Society for Mass Spectrometry, Vol. 22, Issue 8 https://doi.org/10.1007/s13361-011-0163-3	journal	May 2011
Analysis of writing inks on paper using direct analysis in real time mass spectrometry Jones, Roger W.; McClelland, John F. Forensic Science International, Vol. 231, Issue 1-3 https://doi.org/10.1016/j.forsciint.2013.04.016	journal	September 2013
Development and Characterization of a Capillary Gap Sampler as New Microfluidic Device for Fast and Direct Analysis of Low Sample Amounts by ESI-MS Neu, Volker; Steiner, Roger; Müller, Stephan Analytical Chemistry, Vol. 85, Issue 9 https://doi.org/10.1021/ac400186t	journal	April 2013
Analysis of triglycerides in food items by desorption electrospray ionization mass spectrometry: Analysis of triglycerides in food items by DESI-MS Gerbig, Stefanie; Takáts, Zoltán Rapid Communications in Mass Spectrometry, Vol. 24, Issue 15 https://doi.org/10.1002/rcm.4630	journal	June 2010
Automation of a Surface Sampling Probe/Electrospray Mass Spectrometry System Kertesz, Vilmos; Ford, Michael J.; Van Berkel, Gary J. Analytical Chemistry, Vol. 77, Issue 22 https://doi.org/10.1021/ac0510742	journal	November 2005
Instantaneous characterization of vegetable oils via TAG and FFA profiles by easy ambient sonic-spray ionization mass spectrometry Simas, Rosineide C.; Catharino, Rodrigo R.; Cunha, Ildenize B. S. The Analyst, Vol. 135, Issue 4 https://doi.org/10.1039/b923272a	journal	January 2010
Mass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization Monge, María Eugenia; Harris, Glenn A.; Dwivedi, Prabha Chemical Reviews, Vol. 113, Issue 4 https://doi.org/10.1021/cr300309q	journal	January 2013
Forensic analysis of ballpoint pen inks using paper spray mass spectrometry da Silva Ferreira, Priscila; Fernandes de Abreu e. Silva, Débora; Augusti, Rodinei The Analyst, Vol. 140, Issue 3 https://doi.org/10.1039/C4AN01617C	journal	January 2015
Ambient laser ablation sampling for capillary electrophoresis mass spectrometry: Ambient laser ablation sampling for CE/MS Park, Sung-Gun; Murray, Kermit K. Rapid Communications in Mass Spectrometry, Vol. 27, Issue 15 https://doi.org/10.1002/rcm.6618	journal	June 2013
Atmospheric pressure chemical ionization mass spectrometry for analysis of lipids Byrdwell, William Craig Lipids, Vol. 36, Issue 4 https://doi.org/10.1007/s11745-001-0725-5	journal	April 2001
Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions Asano, Keiji G.; Ford, Michael J.; Tomkins, Bruce A. Rapid Communications in Mass Spectrometry, Vol. 19, Issue 16 https://doi.org/10.1002/rcm.2062	journal	January 2005
Liquid microjunction surface sampling of acetaminophen, terfenadine and their metabolites in thin tissue sections Kertesz, Vilmos; Paranthaman, Nithya; Moench, Paul Bioanalysis, Vol. 6, Issue 19 https://doi.org/10.4155/bio.14.130	journal	October 2014
Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins: LMJ-SPP on-line with HPLC/MS Van Berkel, Gary J.; Kertesz, Vilmos Rapid Communications in Mass Spectrometry, Vol. 27, Issue 12 https://doi.org/10.1002/rcm.6580	journal	May 2013
Mechanisms of Real-Time, Proximal Sample Processing during Ambient Ionization Mass Spectrometry Venter, Andre R.; Douglass, Kevin A.; Shelley, Jacob T. Analytical Chemistry, Vol. 86, Issue 1 https://doi.org/10.1021/ac4038569	journal	December 2013
Infrared laser ablation sample transfer for on-line liquid chromatography electrospray ionization mass spectrometry: IR LA sample transfer for on-line LC ESI MS Park, Sung-Gun; Murray, Kermit K. Journal of Mass Spectrometry, Vol. 47, Issue 10 https://doi.org/10.1002/jms.3096	journal	September 2012
Ambient ionisation mass spectrometry for the characterisation of polymers and polymer additives: A review Paine, Martin R. L.; Barker, Philip J.; Blanksby, Stephen J. Analytica Chimica Acta, Vol. 808 https://doi.org/10.1016/j.aca.2013.10.001	journal	January 2014
Electric-field-enhanced collection of laser-ablated materials onto a solvent bridge for electrospray ionization mass spectrometry: Electric-field-assisted sampling of laser-ablated materials Kaufman, Eric; Smith, Whitney; Kowalski, Matthew Rapid Communications in Mass Spectrometry, Vol. 27, Issue 13 https://doi.org/10.1002/rcm.6600	journal	May 2013
Profiling of adrenocorticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS Kertesz, Vilmos; Calligaris, David; Feldman, Daniel R. Analytical and Bioanalytical Chemistry, Vol. 407, Issue 20 https://doi.org/10.1007/s00216-015-8803-2	journal	June 2015
Direct analysis in real time—a critical review on DART-MS Gross, Jürgen H. Analytical and Bioanalytical Chemistry, Vol. 406, Issue 1 https://doi.org/10.1007/s00216-013-7316-0	journal	September 2013
Combination Atmospheric Pressure Solids Analysis Probe and Desorption Electrospray Ionization Mass Spectrometry Ion Source Lloyd, Julie A.; Harron, Andrew F.; McEwen, Charles N. Analytical Chemistry, Vol. 81, Issue 21 https://doi.org/10.1021/ac901324j	journal	November 2009
Forensic applications of ambient ionization mass spectrometry Ifa, Demian R.; Jackson, Ayanna U.; Paglia, Giuseppe Analytical and Bioanalytical Chemistry, Vol. 394, Issue 8 https://doi.org/10.1007/s00216-009-2659-2	journal	February 2009
The Single-Probe: A Miniaturized Multifunctional Device for Single Cell Mass Spectrometry Analysis Pan, Ning; Rao, Wei; Kothapalli, Naga Rama Analytical Chemistry, Vol. 86, Issue 19 https://doi.org/10.1021/ac5029038	journal	September 2014
Analysis of Solids, Liquids, and Biological Tissues Using Solids Probe Introduction at Atmospheric Pressure on Commercial LC/MS Instruments McEwen, Charles N.; McKay, Richard G.; Larsen, Barbara S. Analytical Chemistry, Vol. 77, Issue 23 https://doi.org/10.1021/ac051470k	journal	December 2005
Ambient Infrared Laser Ablation Mass Spectrometry (AIRLAB-MS) of Live Plant Tissue with Plume Capture by Continuous Flow Solvent Probe O’Brien, Jeremy T.; Williams, Evan R.; Holman, Hoi-Ying N. Analytical Chemistry, Vol. 87, Issue 5 https://doi.org/10.1021/ac503383p	journal	February 2015
Combining transmission geometry laser ablation and a non-contact continuous flow surface sampling probe/electrospray emitter for mass spectrometry based chemical imaging: Laser ablation/surface sampling probe chemical imaging Ovchinnikova, Olga S.; Kertesz, Vilmos; Van Berkel, Gary J. Rapid Communications in Mass Spectrometry, Vol. 25, Issue 24 https://doi.org/10.1002/rcm.5285	journal	November 2011
Automated liquid microjunction surface sampling-HPLC–MS/MS analysis of drugs and metabolites in whole-body thin tissue sections Kertesz, Vilmos; Van Berkel, Gary J. Bioanalysis, Vol. 5, Issue 7 https://doi.org/10.4155/bio.13.42	journal	April 2013
Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry Van Berkel, Gary J.; Pasilis, Sofie P.; Ovchinnikova, Olga Journal of Mass Spectrometry, Vol. 43, Issue 9 https://doi.org/10.1002/jms.1440	journal	September 2008
Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry Roach, Patrick J.; Laskin, Julia; Laskin, Alexander The Analyst, Vol. 135, Issue 9 https://doi.org/10.1039/c0an00312c	journal	January 2010
Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry Otsuka, Yoichi; Shide, Sayuri; Naito, Junpei Rapid Communications in Mass Spectrometry, Vol. 26, Issue 23 https://doi.org/10.1002/rcm.6399	journal	October 2012
Swan Probe: A Nanoliter-Scale and High-Throughput Sampling Interface for Coupling Electrospray Ionization Mass Spectrometry with Microfluidic Droplet Array and Multiwell Plate Jin, Di-Qiong; Zhu, Ying; Fang, Qun Analytical Chemistry, Vol. 86, Issue 21 https://doi.org/10.1021/ac503014k	journal	October 2014
High-Throughput Mode Liquid Microjunction Surface Sampling Probe Van Berkel, Gary J.; Kertesz, Vilmos; King, Richard C. Analytical Chemistry, Vol. 81, Issue 16 https://doi.org/10.1021/ac901098d	journal	August 2009
Why minimally invasive skin sampling techniques? A bright scientific future Wang, Christina Y.; Maibach, Howard I. Cutaneous and Ocular Toxicology, Vol. 30, Issue 1 https://doi.org/10.3109/15569527.2010.517230	journal	October 2010
The State of the Art on the Use of Oral Fluid as Alternative Specimen in Forensic Toxicology De Giovanni, Nadia; Fucci, Nadia Current Pharmaceutical Analysis, Vol. 4, Issue 4 https://doi.org/10.2174/157341208786306180	journal	November 2008
Stationary bathtub vortices and a critical regime of liquid discharge Stepanyants, Yury A.; Yeoh, Guan H. Journal of Fluid Mechanics, Vol. 604 https://doi.org/10.1017/S0022112008001080	journal	May 2008
Liquid Microjunction Surface Sampling Probe Fluid Dynamics: Computational and Experimental Analysis of Coaxial Intercapillary Positioning Effects on Sample Manipulation ElNaggar, Mariam S.; Barbier, Charlotte; Van Berkel, Gary J. Journal of The American Society for Mass Spectrometry, Vol. 22, Issue 7 https://doi.org/10.1007/s13361-011-0145-5	journal	April 2011
Laser Ablation Sampling of Materials Directly into the Formed Liquid Microjunction of a Continuous Flow Surface Sampling Probe/Electrospray Ionization Emitter for Mass Spectral Analysis and Imaging Ovchinnikova, Olga S.; Lorenz, Matthias; Kertesz, Vilmos Analytical Chemistry, Vol. 85, Issue 21 https://doi.org/10.1021/ac4018499	journal	October 2013
Real-Time Metabolomics on Living Microorganisms Using Ambient Electrospray Ionization Flow-Probe Hsu, Cheng-Chih; ElNaggar, Mariam S.; Peng, Yao Analytical Chemistry, Vol. 85, Issue 15 https://doi.org/10.1021/ac401613x	journal	July 2013
Ambient mass spectrometry employing direct analysis in real time (DART) ion source for olive oil quality and authenticity assessment Vaclavik, Lukas; Cajka, Tomas; Hrbek, Vojtech Analytica Chimica Acta, Vol. 645, Issue 1-2 https://doi.org/10.1016/j.aca.2009.04.043	journal	July 2009
Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography−Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections Kertesz, Vilmos; Van Berkel, Gary J. Analytical Chemistry, Vol. 82, Issue 14 https://doi.org/10.1021/ac100954p	journal	July 2010
Thin-Layer Chromatography and Electrospray Mass Spectrometry Coupled Using a Surface Sampling Probe Van Berkel, Gary J.; Sanchez, Amaury D.; Quirke, J. Martin E. Analytical Chemistry, Vol. 74, Issue 24 https://doi.org/10.1021/ac020540+	journal	November 2002
Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform Kertesz, Vilmos; Van Berkel, Gary J. Journal of Mass Spectrometry, Vol. 45, Issue 3 https://doi.org/10.1002/jms.1709	journal	March 2010
Forensic analysis of inks by imaging desorption electrospray ionization (DESI) mass spectrometry Ifa, D. R.; Gumaelius, L. M.; Eberlin, L. S. The Analyst, Vol. 132, Issue 5 https://doi.org/10.1039/b700236j	journal	January 2007
Transmission geometry laser ablation into a non-contact liquid vortex capture probe for mass spectrometry imaging Ovchinnikova, Olga S.; Bhandari, Deepak; Lorenz, Matthias Rapid Communications in Mass Spectrometry, Vol. 28, Issue 15, p. 1665-1673 https://doi.org/10.1002/rcm.6946	journal	June 2014
Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions Cody, Robert B.; Laramée, James A.; Durst, H. Dupont Analytical Chemistry, Vol. 77, Issue 8, p. 2297-2302 https://doi.org/10.1021/ac050162j	journal	April 2005
Combining Laser Ablation/Liquid Phase Collection Surface Sampling and High-Performance Liquid Chromatography−Electrospray Ionization-Mass Spectrometry Ovchinnikova, Olga S.; Kertesz, Vilmos; Van Berkel, Gary J. Analytical Chemistry, Vol. 83, Issue 6 https://doi.org/10.1021/ac200051y	journal	March 2011
High-Throughput Cell and Tissue Analysis with Enhanced Molecular Coverage by Laser Ablation Electrospray Ionization Mass Spectrometry Using Ion Mobility Separation Shrestha, Bindesh; Vertes, Akos Analytical Chemistry, Vol. 86, Issue 9 https://doi.org/10.1021/ac500007t	journal	April 2014
An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis Kertesz, Vilmos; Weiskittel, Taylor M.; Van Berkel, Gary J. Analytical and Bioanalytical Chemistry, Vol. 407, Issue 8 https://doi.org/10.1007/s00216-014-8287-5	journal	November 2014
Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology Takáts, Zoltán; Wiseman, Justin M.; Cooks, R. Graham Journal of Mass Spectrometry, Vol. 40, Issue 10 https://doi.org/10.1002/jms.922	journal	October 2005
Electrochemical Push–Pull Scanner with Mass Spectrometry Detection Momotenko, Dmitry; Qiao, Liang; Cortés-Salazar, Fernando Analytical Chemistry, Vol. 84, Issue 15 https://doi.org/10.1021/ac300999v	journal	July 2012
Mass spectrometric metabolomic imaging of biofilms on corroding steel surfaces using laser ablation and solvent capture by aspiration Brauer, Jonathan I.; Makama, Zakari; Bonifay, Vincent Biointerphases, Vol. 10, Issue 1 https://doi.org/10.1116/1.4906744	journal	March 2015
Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging Lorenz, Matthias; Ovchinnikova, Olga S.; Kertesz, Vilmos Analytical Chemistry, Vol. 86, Issue 6 https://doi.org/10.1021/ac404249j	journal	March 2014
Atmospheric Solid Analysis Probe–Ion Mobility Mass Spectrometry of Polypropylene Barrère, Caroline; Maire, Florian; Afonso, Carlos Analytical Chemistry, Vol. 84, Issue 21 https://doi.org/10.1021/ac302109q	journal	September 2012

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open port sampling interface
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skin
vegetable oil

Title: An Open Port Sampling Interface for Liquid Introduction Atmospheric Pressure Ionization Mass Spectrometry

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