A biokinetic model for systemic technetium in adult humans

Leggett, Richard Wayne; Giussani, Augusto

doi:10.1088/0952-4746/35/2/297

Title: A biokinetic model for systemic technetium in adult humans

Journal Article · Fri Apr 10 00:00:00 EDT 2015 · Journal of Radiological Protection

DOI:https://doi.org/10.1088/0952-4746/35/2/297· OSTI ID:1213986

Leggett, Richard Wayne ^[1]; Giussani, Augusto ^[2]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Federal Office for Radiation Protection, Oberschleisheim (Germany)

The International Commission on Radiological Protection (ICRP) currently is updating its biokinetic and dosimetric models for internally deposited radionuclides. Technetium (Tc), the lightest element that exists only in radioactive form, has two important isotopes from the standpoint of potential risk to humans: the long-lived isotope⁹⁹Tm(T_1/2=2.1x10⁵ y) is present in high concentration in nuclear waste, and the short-lived isotope ^99mTc (T_1/2=6.02 h) is the most commonly used radionuclide in diagnostic nuclear medicine. This paper reviews data on the biological behavior of technetium and proposes a biokinetic model for systemic technetium in the adult human body for use in radiation protection. Compared with the ICRP s current occupational model for systemic technetium, the proposed model provides a more realistic description of the paths of movement of technetium in the body; provides greater consistency with experimental and medical data; and, for most radiosensitive organs, yields substantially different estimates of cumulative activity (total radioactive decays within the organ) following uptake of ⁹⁹Tm or ⁹⁹mTc to blood.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1213986

Journal Information:: Journal of Radiological Protection, Vol. 35, Issue 2; ISSN 0952-4746

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 11 works

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Cited By (2)

Dose-response relationships between internally-deposited uranium and select health outcomes in gaseous diffusion plant workers, 1948-2011 Yiin, James H.; Anderson, Jeri L.; Bertke, Stephen J. American Journal of Industrial Medicine, Vol. 61, Issue 7 https://doi.org/10.1002/ajim.22858	journal	May 2018
IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms Andersson, Martin; Johansson, Lennart; Eckerman, Keith EJNMMI Research, Vol. 7, Issue 1 https://doi.org/10.1186/s13550-017-0339-3	journal	November 2017

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62 RADIOLOGY AND NUCLEAR MEDICINE
technetium
biokinetics
radionuclide
nuclear
waste
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Title: A biokinetic model for systemic technetium in adult humans

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