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Title: Clock-like mutational processes in human somatic cells

Conference ·
DOI:https://doi.org/10.1038/ng.3441· OSTI ID:1213502

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE Laboratory Directed Research and Development (LDRD) Program
DOE Contract Number:
AC52-06NA25396
OSTI ID:
1213502
Report Number(s):
LA-UR-15-26851
Resource Relation:
Journal Volume: 47; Journal Issue: 12; Conference: European Environmental Mutagenesis and Genomics Society ; 2015-08-23 - 2015-08-29 ; Prague, Czech Republic
Country of Publication:
United States
Language:
English

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Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations journal August 2018
The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles journal November 2017
Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma journal April 2017
Aging and the rise of somatic cancer-associated mutations in normal tissues journal January 2018
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The genome-wide landscape of C:G > T:A polymorphism at the CpG contexts in the human population journal March 2020
Molecular and clonal evolution in recurrent metastatic gliosarcoma journal January 2020
Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan journal April 2019
Relation between DNA ionization potentials, single base substitutions and pathogenic variants journal July 2019
Hidden Markov models lead to higher resolution maps of mutation signature activity in cancer journal July 2019
Somatic genome alterations in relation to age in lung squamous cell carcinoma journal August 2018
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. journalarticle January 2018
The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes journal May 2017
5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA journal May 2016
Different mutational characteristics of the subsets of EGFR-tyrosine kinase inhibitor sensitizing mutation-positive lung adenocarcinoma journal December 2018
Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type journal December 2019
Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer journal June 2019
Discovering novel mutation signatures by latent Dirichlet allocation with variational Bayes inference journal April 2019
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer journal January 2020
Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry journal July 2018
Author Correction: The effects of mutational processes and selection on driver mutations across cancer types journal April 2020
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis journal January 2018
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma journal January 2019
An alternative model for (breast) cancer predisposition journal April 2017
The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts journal October 2016
Single-Cell Analysis Based Dissection of Clonality in Myelofibrosis journal November 2019
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery journal November 2018
Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models journal February 2019
Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity text January 2018
Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making journal April 2018
Burden of unique and low prevalence somatic mutations correlates with cancer survival journal March 2019
Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome journal June 2019
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma journal May 2019
Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates journalarticle January 2017
Somatic mutations in neurons during aging and neurodegeneration journal April 2018
Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk journal November 2019
DNA Repair Pathway Alterations in Bladder Cancer journal March 2017
Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia journal January 2019
Epidermal Darwinism and Competitive Equilibrium within the Epidermis journal November 2018
Mutational processes shape the landscape of TP53 mutations in human cancer journal September 2018
Genomic features of renal cell carcinoma with venous tumor thrombus journal May 2018
A new timepiece: an epigenetic mitotic clock journal October 2016
Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine journal December 2016
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal journal April 2018
Base changes in tumour DNA have the power to reveal the causes and evolution of cancer journal June 2016
DNA methylation loss in late-replicating domains is linked to mitotic cell division journal April 2018
Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations journal December 2018
Measuring intratumor heterogeneity by network entropy using RNA-seq data journal November 2016
EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancer journal August 2019
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development journal August 2016
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas journal May 2016
Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome journal April 2017
Uncovering a unique approach for damaged DNA replication: A computational investigation of a mutagenic tobacco-derived thymine lesion journal January 2019
Somatic Variants in the Human Lens Epithelium: A Preliminary Assessment journal August 2016
Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation journal July 2019
The repertoire of mutational signatures in human cancer journal February 2020
Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection journal October 2018
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours journal February 2018
Rational design of non-resistant targeted cancer therapies journal April 2017
Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations journal November 2018
High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations journal February 2018
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis journal November 2018
Epstein–Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation journal July 2016
Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer journal March 2016
A comprehensive survey of the mutagenic impact of common cancer cytotoxics journal May 2016
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis journal March 2019
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer journal November 2018
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig journal February 2020
Differences between germline and somatic mutation rates in humans and mice journal May 2017
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