Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

Lee, Hyun; Lei, Hao; Santarsiero, Bernard D.; Gatuz, Joseph L.; Cao, Shuyi; Rice, Amy J.; Patel, Kavankumar; Szypulinski, Michael Z.; Ojeda, Isabel; Ghosh, Arun K.; Johnson, Michael E.

doi:10.1021/cb500917m

Title: Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

Journal Article · Fri Jun 19 00:00:00 EDT 2015 · ACS Chem. Biol.

DOI:https://doi.org/10.1021/cb500917m· OSTI ID:1188829

Lee, Hyun; Lei, Hao; Santarsiero, Bernard D.; Gatuz, Joseph L.; Cao, Shuyi; Rice, Amy J.; Patel, Kavankumar; Szypulinski, Michael Z.; Ojeda, Isabel; Ghosh, Arun K.; Johnson, Michael E. ^[1]

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Institutes of Health (NIH)

OSTI ID:: 1188829

Journal Information:: ACS Chem. Biol., Vol. 10, Issue (6) ; 06, 2015

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 79 works

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Development of Small-Molecule MERS-CoV Inhibitors Liang, Ruiying; Wang, Lili; Zhang, Naru Viruses, Vol. 10, Issue 12 https://doi.org/10.3390/v10120721	journal	December 2018
Molecular Dynamics and Inhibition of MERS CoV Papain-like Protease by Small Molecule Imidazole and Aminopurine Derivatives Kandeel, Mahmoud; Altaher, Abdallah; Alnazawi, Mohamed Letters in Drug Design & Discovery, Vol. 16, Issue 5 https://doi.org/10.2174/1570180815666180918161922	journal	April 2019
Coronaviruses — drug discovery and therapeutic options Zumla, Alimuddin; Chan, Jasper F. W.; Azhar, Esam I. Nature Reviews Drug Discovery, Vol. 15, Issue 5 https://doi.org/10.1038/nrd.2015.37	journal	February 2016
Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants Zhang, Wei; Bailey-Elkin, Ben A.; Knaap, Robert C. M. PLOS Pathogens, Vol. 13, Issue 5 https://doi.org/10.1371/journal.ppat.1006372	journal	May 2017
Recent progress in the discovery of inhibitors targeting coronavirus proteases Wang, Haofeng; Xue, Song; Yang, Haitao Virologica Sinica, Vol. 31, Issue 1 https://doi.org/10.1007/s12250-015-3711-3	journal	February 2016
Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin Lei, Jian; Hilgenfeld, Rolf Virologica Sinica, Vol. 31, Issue 4 https://doi.org/10.1007/s12250-016-3742-4	journal	May 2016
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach Choudhury, Shuvasish; Moulick, Debojyoti; Borah, Anupom In Silico Pharmacology, Vol. 9, Issue 1 https://doi.org/10.1007/s40203-021-00085-y	journal	April 2021
Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes Lin, Min-Han; Moses, David C.; Hsieh, Chih-Hua Antiviral Research, Vol. 150 https://doi.org/10.1016/j.antiviral.2017.12.015	journal	February 2018
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element Galasiti Kankanamalage, Anushka C.; Kim, Yunjeong; Damalanka, Vishnu C. European Journal of Medicinal Chemistry, Vol. 150 https://doi.org/10.1016/j.ejmech.2018.03.004	journal	April 2018
Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins Li, Yan-Hua; Hu, Chen-Yu; Wu, Nan-Ping Engineering, Vol. 5, Issue 5 https://doi.org/10.1016/j.eng.2018.11.035	journal	October 2019
Structure and Function of Viral Deubiquitinating Enzymes Bailey-Elkin, Ben A.; Knaap, Robert C. M.; Kikkert, Marjolein Journal of Molecular Biology, Vol. 429, Issue 22 https://doi.org/10.1016/j.jmb.2017.06.010	journal	November 2017
Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control Durai, Prasannavenkatesh; Batool, Maria; Shah, Masaud Experimental & Molecular Medicine, Vol. 47, Issue 8 https://doi.org/10.1038/emm.2015.76	journal	August 2015
Drug repurposing against MERS CoV and SARS-COV-2 PL^pro in silico Elfiky, Abdo; Ibrahim, Noha; Elshemey, Wael Research Square https://doi.org/10.21203/rs.3.rs-19600/v1	journal	March 2020
Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling Lee, Hyun; Ren, Jinhong; Pesavento, Russell University of Illinois at Chicago https://doi.org/10.25417/uic.19719751	text	January 2022
In silico Drug Repurposing for COVID-19: Targeting SARS-CoV-2 Proteins through Docking and Quantum Mechanical Scoring Cavasotto, Claudio; Di Filippo, Juan https://doi.org/10.26434/chemrxiv.12110199	preprint	May 2020
UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity Lin, Junyan; Ai, Yongxing; Zhou, Hongda International Journal of Molecular Sciences, Vol. 21, Issue 5 https://doi.org/10.3390/ijms21051783	journal	March 2020

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