Polychlorinated biphenyls (PCBs) depress allogeneic natural cytotoxicity by earthworm coelomocytes

Journal Article · Sun Oct 01 00:00:00 EDT 1995 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1002/etc.5620141009· OSTI ID:118640

Suzuki, M M; Cooper, E L ^[1]; Eyambe, G S; Goven, A J; Fitzpatrick, L C ^[2]; Venables, B J ^[2]

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1. Univ. of California, Los Angeles, CA (United States). Lab. of Comparative Immunology
2. Univ. of North Texas, Denton, TX (United States). Dept. of Biological Sciences

Coelomocytes of the earthworm Lumbricus terrestris caused significant spontaneous allogeneic cytotoxicity in a 24-h trypan blue assay, but not in an assay using lactate dehydrogenase (LDH) release. Allogeneic cytotoxicity assays using cells from worms exposed to polychlorinated biphenyls (PCBs) suggest that PCBs can suppress a natural killing (NK-like) reaction. The implications of this work are twofold: understanding the evolution of natural killing (NK-like) activity and providing preliminary information on how spontaneous killing, a component of cellular immunity, may be compromised by pollutants.

• Sponsoring Organization: USDOE
• OSTI ID: 118640
• Journal Information: Environmental Toxicology and Chemistry, Vol. 14, Issue 10; Other Information: PBD: Oct 1995
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
POLYCHLORINATED BIPHENYLS
BIOLOGICAL EFFECTS
ANNELIDS
SURVIVAL TIME
BIOASSAY
OXIDOREDUCTASES