Characterization of a novel insect-specific flavivirus from Brazil: Potential for inhibition of infection of arthropod cells with medically important flaviviruses.

Kenney, Joan L.; Solberg, Owen D.; Langevin, Stanley A.; Brault, Aaron C.

doi:10.1099/vir.0.068031-0

Title: Characterization of a novel insect-specific flavivirus from Brazil: Potential for inhibition of infection of arthropod cells with medically important flaviviruses.

Journal Article · Sun Jan 12 00:00:00 EST 2014 · Journal of General Virology

DOI:https://doi.org/10.1099/vir.0.068031-0· OSTI ID:1185007

Kenney, Joan L. ^[1]; Solberg, Owen D. ^[2]; Langevin, Stanley A. ^[2]; Brault, Aaron C. ^[1]

Centers for Disease Control and Prevention, Fort Collins, CO (United States)
Sandia National Lab. (SNL-CA), Livermore, CA (United States)

In the past decade, there has been an upsurge in the number of newly described insect-specific flaviviruses isolated pan-globally. We recently described the isolation of a novel flavivirus (tentatively designated ‘Nhumirim virus’; NHUV) that represents an example of a unique subset of apparently insect-specific viruses that phylogenetically affiliate with dual-host mosquito-borne flaviviruses despite appearing to be limited to replication in mosquito cells. We characterized the in vitro growth potential and 3' untranslated region (UTR) sequence homology with alternative flaviviruses, and evaluated the virus’s capacity to suppress replication of representative Culex spp.-vectored pathogenic flaviviruses in mosquito cells. Only mosquito cell lines were found to support NHUV replication, further reinforcing the insect-specific phenotype of this virus. Analysis of the sequence and predicted RNA secondary structures of the 3' UTR indicated NHUV to be most similar to viruses within the yellow fever serogroup and Japanese encephalitis serogroup, and viruses in the tick-borne flavivirus clade. NHUV was found to share the fewest conserved sequence elements when compared with traditional insect-specific flaviviruses. This suggests that, despite apparently being insect specific, this virus probably diverged from an ancestral mosquito-borne flavivirus. Co-infection experiments indicated that prior or concurrent infection of mosquito cells with NHUV resulted in a significant reduction in virus production of West Nile virus (WNV), St Louis encephalitis virus (SLEV) and Japanese encephalitis virus. As a result, the inhibitory effect was most effective against WNV and SLEV with over a 106-fold and 104-fold reduction in peak titres, respectively.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1185007

Report Number(s):: SAND-2014-20423J; 547755

Journal Information:: Journal of General Virology, Vol. 95, Issue 12; ISSN 0022-1317

Publisher:: Microbiology SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Insect-specific virus evolution and potential effects on vector competence Öhlund, Pontus; Lundén, Hanna; Blomström, Anne-Lie Virus Genes, Vol. 55, Issue 2 https://doi.org/10.1007/s11262-018-01629-9	journal	January 2019
Natural Variation in Resistance to Virus Infection in Dipteran Insects Palmer, William; Varghese, Finny; van Rij, Ronald Viruses, Vol. 10, Issue 3 https://doi.org/10.3390/v10030118	journal	March 2018
Restriction of Zika virus infection and transmission in Aedes aegypti mediated by an insect-specific flavivirus Romo, Hannah; Kenney, Joan L.; Blitvich, Bradley J. Emerging Microbes & Infections, Vol. 7, Issue 1 https://doi.org/10.1038/s41426-018-0180-4	journal	December 2018
Vector Competence: What Has Zika Virus Taught Us? Azar, Sasha R.; Weaver, Scott C. Viruses, Vol. 11, Issue 9 https://doi.org/10.3390/v11090867	journal	September 2019
Mosquito Small RNA Responses to West Nile and Insect-Specific Virus Infections in Aedes and Culex Mosquito Cells Göertz, Giel; Miesen, Pascal; Overheul, Gijs Viruses, Vol. 11, Issue 3 https://doi.org/10.3390/v11030271	journal	March 2019
Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes Kean, Joy; Rainey, Stephanie; McFarlane, Melanie Insects, Vol. 6, Issue 1 https://doi.org/10.3390/insects6010236	journal	March 2015
Insect-Specific Virus Discovery: Significance for the Arbovirus Community Bolling, Bethany; Weaver, Scott; Tesh, Robert Viruses, Vol. 7, Issue 9 https://doi.org/10.3390/v7092851	journal	September 2015
Novel viruses in salivary glands of mosquitoes from sylvatic Cerrado, Midwestern Brazil Lara Pinto, Andressa Zelenski de; Santos de Carvalho, Michellen; de Melo, Fernando Lucas PLOS ONE, Vol. 12, Issue 11 https://doi.org/10.1371/journal.pone.0187429	journal	November 2017
On the Fly: Interactions Between Birds, Mosquitoes, and Environment That Have Molded West Nile Virus Genomic Structure Over Two Decades Duggal, Nisha K.; Langwig, Kate E.; Ebel, Gregory D. Journal of Medical Entomology, Vol. 56, Issue 6 https://doi.org/10.1093/jme/tjz112	journal	September 2019
The insect-specific Palm Creek virus modulates West Nile virus infection in and transmission by Australian mosquitoes Hall-Mendelin, Sonja; McLean, Breeanna J.; Bielefeldt-Ohmann, Helle Parasites & Vectors, Vol. 9, Issue 1 https://doi.org/10.1186/s13071-016-1683-2	journal	July 2016
Viral Interference and Persistence in Mosquito-Borne Flaviviruses Salas-Benito, Juan Santiago; De Nova-Ocampo, Mónica Journal of Immunology Research, Vol. 2015 https://doi.org/10.1155/2015/873404	journal	January 2015
Mosquito-Specific Viruses—Transmission and Interaction Agboli, Eric; Leggewie, Mayke; Altinli, Mine Viruses, Vol. 11, Issue 9, p. 873 https://doi.org/10.3390/v11090873	journal	September 2019

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