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Title: Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

Journal Article · · Mol. Cell

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
USDOE Office of Science (SC)
OSTI ID:
1184859
Journal Information:
Mol. Cell, Vol. 58, Issue (5) ; 06, 2015
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 58 works
Citation information provided by
Web of Science

References (67)

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The Ard1 Gene from Streptomyces capreolus Encodes a Polypeptide of the ABC-Transporters Superfamily Which Confers Resistance to the Aminonucleoside Antibiotic A201A journal March 1995
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An O-Phosphotransferase Catalyzes Phosphorylation of Hygromycin A in the Antibiotic-Producing Organism Streptomyces hygroscopicus journal July 2008
The Final Step of Hygromycin A Biosynthesis, Oxidation of C-5″-Dihydrohygromycin A, Is Linked to a Putative Proton Gradient-Dependent Efflux journal September 2009
Synthesis of (−)-Hygromycin A: Application of Mitsunobu Glycosylation and Tethered Aminohydroxylation journal August 2009
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action journal September 2010
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Cited By (28)

Totalsynthese und Strukturkorrektur des antibiotisch wirksamen Tetrapeptids GE81112A journal August 2018
Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A journal August 2018
Nature’s combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces journal March 2017
Structural and evolutionary insights into ribosomal RNA methylation journal February 2018
How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome journal October 2016
Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition journal October 2019
Dynamics of the context-specific translation arrest by chloramphenicol and linezolid journal December 2019
Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs journal January 2019
Diffusion of tRNA inside the ribosome is position-dependent journal August 2019
Pseudouridinylation of mRNA coding sequences alters translation journal October 2019
Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection journal February 2020
tRNA structure and evolution and standardization to the three nucleotide genetic code journal April 2017
Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition journal January 2016
Structural dynamics of translation elongation factor Tu during aa-tRNA delivery to the ribosome journal August 2018
Ribosome dynamics during decoding journal March 2017
cfrB, cfrC , and a potential new cfr -like gene in Clostridium difficile strains recovered across Latin America journal May 2019
Bacterial Protein Synthesis as a Target for Antibiotic Inhibition journal August 2016
cfr (B), cfr (C), and a New cfr -Like Gene, cfr (E), in Clostridium difficile Strains Recovered across Latin America journal November 2019
Ornithine capture by a translating ribosome controls bacterial polyamine synthesis journal February 2020
Dynamics of the context-specific translation arrest by chloramphenicol and linezolid text January 2021
A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest journal July 2016
Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale journal February 2016
Structure of the mammalian antimicrobial peptide Bac7(1–16) bound within the exit tunnel of a bacterial ribosome journal January 2016
Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome journal April 2016
Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme journal August 2016
Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state journal May 2017
Molecular Insights into Determinants of Translational Readthrough and Implications for Nonsense Suppression Approaches journal December 2020
Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A. journalarticle January 2015

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