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Title: Lipid-peptide-polymer conjugates and nanoparticles thereof

Patent ·
OSTI ID:1183465
; ;

The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
Regents of the University of California (Oakland, CA)
Patent Number(s):
9,044,514
Application Number:
13/610,637
OSTI ID:
1183465
Country of Publication:
United States
Language:
English

References (10)

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof patent November 2008
Particulate Constructs For Release of Active Agents patent-application December 2008
Coiled-Coil Lipopeptide Helical Bundles and Synthetic Virus-Like Particles patent-application January 2010
Magainins as paradigm for the mode of action of pore forming polypeptides journal November 1998
Water self-diffusion in nonionic surfactant solutions. Hydration and obstruction effects journal November 1983
The crystal structure of the designed trimeric coiled coil coil-VaLd: Implications for engineering crystals and supramolecular assemblies journal January 1997
New Design of Helix Bundle Peptide−Polymer Conjugates journal August 2008
Protein Folding: A Glimpse of the Holy Grail? journal October 1998
Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion journal October 1972
Pharmaceutics and Drug Delivery Aspects of Heme and Porphyrin Therapy journal May 1993

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
77 NANOSCIENCE AND NANOTECHNOLOGY