Systematic identification of genes and transduction pathways involved in radio-adaptive response
Technical Report
·
OSTI ID:1182410
Low doses of radiation have been shown to protect against the biological effects of later exposure to toxic levels of radiation. In this study, we propose to identify the molecular mechanisms of this adaptive response by systematically identifying the genes that play a role in radio-protection. In the original proposal, a human cell line that is well-documented to exhibit the radio-adaptive effect was to be used. In this revised study plan, we will use a mouse model, C57BL/6, which has also been well investigated for radio-adaptation. The goal of the proposed study is to enhance our understanding of cellular responses to low doses of radiation exposure at the molecular level.
- Research Organization:
- NASA Johnson Space Center, Houston, TX (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- Contributing Organization:
- NASA
- DOE Contract Number:
- SC0002497
- OSTI ID:
- 1182410
- Country of Publication:
- United States
- Language:
- English
Similar Records
The Adaptive Response in p53 Cancer Prone Mice: Loss of heterozygosity and Genomic Instability
Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation
Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease
Technical Report
·
Tue Sep 28 00:00:00 EDT 2004
·
OSTI ID:1182410
+1 more
Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation
Technical Report
·
Fri Mar 30 00:00:00 EDT 2012
·
OSTI ID:1182410
Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease
Journal Article
·
Fri Jun 06 00:00:00 EDT 2008
· Radiation Research
·
OSTI ID:1182410
+1 more