Trapping a transition state in a computationally designed protein bottle

Pearson, Aaron D.; Mills, Jeremy H.; Song, Yifan; Nasertorabi, Fariborz; Han, Gye Won; Baker, David; Stevens, Raymond C.; Schultz, Peter G.

doi:10.1126/science.aaa2424

Title: Trapping a transition state in a computationally designed protein bottle

Journal Article · Thu Feb 19 00:00:00 EST 2015 · Science

DOI:https://doi.org/10.1126/science.aaa2424· OSTI ID:1182312

Pearson, Aaron D.; Mills, Jeremy H.; Song, Yifan; Nasertorabi, Fariborz; Han, Gye Won; Baker, David; Stevens, Raymond C.; Schultz, Peter G. ^[1]

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DHS - DEPARTMENT OF HOMELAND SECURITYNIHNIGMS

OSTI ID:: 1182312

Journal Information:: Science, Vol. 347, Issue 02, 2015

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 33 works

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Protein design: from computer models to artificial intelligence: Protein design Paladino, Antonella; Marchetti, Filippo; Rinaldi, Silvia Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 7, Issue 5 https://doi.org/10.1002/wcms.1318	journal	May 2017
Expanding and reprogramming the genetic code Chin, Jason W. Nature, Vol. 550, Issue 7674 https://doi.org/10.1038/nature24031	journal	October 2017
Designed metalloprotein stabilizes a semiquinone radical Ulas, Gözde; Lemmin, Thomas; Wu, Yibing Nature Chemistry, Vol. 8, Issue 4 https://doi.org/10.1038/nchem.2453	journal	February 2016
Smooth heuristic optimization on a complex chemical subspace Elward, Jennifer M.; Rinderspacher, B. Christopher Physical Chemistry Chemical Physics, Vol. 17, Issue 37 https://doi.org/10.1039/c5cp02177d	journal	January 2015
Enriched optimization of molecular properties under constraints: an electrochromic example Rinderspacher, B. Christopher; Elward, Jennifer M. Molecular Systems Design & Engineering, Vol. 3, Issue 3 https://doi.org/10.1039/c7me00126f	journal	January 2018
A transition state “trapped”? QM-cluster models of engineered threonyl-tRNA synthetase Summers, Thomas J.; Cheng, Qianyi; DeYonker, Nathan J. Organic & Biomolecular Chemistry, Vol. 16, Issue 22 https://doi.org/10.1039/c8ob00540k	journal	January 2018
Protein engineering: the potential of remote mutations Wilding, Matthew; Hong, Nansook; Spence, Matthew Biochemical Society Transactions, Vol. 47, Issue 2 https://doi.org/10.1042/bst20180614	journal	March 2019
At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code Xiao, Han; Schultz, Peter G. Cold Spring Harbor Perspectives in Biology, Vol. 8, Issue 9 https://doi.org/10.1101/cshperspect.a023945	journal	July 2016

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