Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

Lewandowski, Eric M.; Skiba, Joanna; Torelli, Nicholas J.; Rajnisz, Aleksandra; Solecka, Jolanta; Kowalski, Konrad; Chen, Yu

doi:10.1039/C5CC00904A

Title: Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

Journal Article · Mon Mar 02 00:00:00 EST 2015 · ChemComm

DOI:https://doi.org/10.1039/C5CC00904A· OSTI ID:1178850

Lewandowski, Eric M. ^[1]; Skiba, Joanna ^[2]; Torelli, Nicholas J. ^[1]; Rajnisz, Aleksandra ^[3]; Solecka, Jolanta ^[3]; Kowalski, Konrad ^[2]; Chen, Yu ^[1]

Univ. of South Florida, Tampa, FL (United States). Dept. of PMolecular Medicine
Univ. of Lodz (Poland). Dept. of Organic Chemistry
National Inst. of Public Health - National Inst. of Hygiene (NIPH-NIH), Warsaw (Poland)

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.

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Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: W-31-109-Eng-38; DEC-2013/11/B/ST5/00997

OSTI ID:: 1178850

Journal Information:: ChemComm, Vol. 51, Issue 28; ISSN 1359-7345

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 29 works

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Title: Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic

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