Challenges for In vitro to in Vivo Extrapolation of Nanomaterial Dosimetry for Human Risk Assessment
Journal Article
·
· Gradient EH&S Nano News, 8(3):4
OSTI ID:1177355
The proliferation in types and uses of nanomaterials in consumer products has led to rapid application of conventional in vitro approaches for hazard identification. Unfortunately, assumptions pertaining to experimental design and interpretation for studies with chemicals are not generally appropriate for nanomaterials. The fate of nanomaterials in cell culture media, cellular dose to nanomaterials, cellular dose to nanomaterial byproducts, and intracellular fate of nanomaterials at the target site of toxicity all must be considered in order to accurately extrapolate in vitro results to reliable predictions of human risk.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1177355
- Report Number(s):
- PNNL-SA-99026; 400412000
- Journal Information:
- Gradient EH&S Nano News, 8(3):4, Journal Name: Gradient EH&S Nano News, 8(3):4
- Country of Publication:
- United States
- Language:
- English
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