Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Brinker, C Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao; Liu, Juewen; Peabody, David S; Wharton, Walker Richard; Carnes, Eric; Chackerian, Bryce; Willman, Cheryl L

Title: Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Patent · Tue Mar 31 00:00:00 EDT 2015

OSTI ID:1177123

Brinker, C Jeffrey; Ashley, Carlee Erin; Jiang, Xingmao; Liu, Juewen; Peabody, David S; Wharton, Walker Richard; Carnes, Eric; Chackerian, Bryce; Willman, Cheryl L

Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

View Patent

Cite

Export

Save

Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: STC.UNM (Albuquergue, NM)

Patent Number(s):: 8,992,984

Application Number:: 12/909,572

OSTI ID:: 1177123

Resource Relation:: Patent File Date: 2010 Oct 21

Country of Publication:: United States

Language:: English

References (24)

Detection systems utilizing supported lipid bilayers Lopez, Gabriel P.; Zeineldin, Reema; Piyasena, Menake E. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7514267 US Patent Document 7,514,267	patent	April 2009
Porous nanoparticle supported lipid bilayer nanostructures Liu, Juewen; Brinker, Jeffrey C.; Ashley, Carlee Erin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8734816 US Patent Document 8,734,816	patent	May 2014
Layered Nanoparticles Kong, Linggen; Barbe, Christophe Jean Alexander https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080095852 US Patent Application 11/816052; 20080095852	patent-application	April 2008
Porous Nanoparticle Supported Lipid Bilayer Nanostructures Liu, Juewen; Brinker, Jeffrey C.; Ashley, Carlee https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110268791 US Patent Document 13/143164; 20110268791	patent-application	November 2011
Porous Nanoparticle-Supported Lipid Bilayers (Photocells) for Targeted Delivery and Methods of Using Same Brinker, C. Jeffrey; Carnes, Eric C.; Ashley, Carleen Erin https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140079774 US Patent Application 14/113371; 20140079774	patent-application	March 2014
Barriers to Drug Delivery in Solid Tumors Jain, Rakesh K. Scientific American, Vol. 271, Issue 1 https://doi.org/10.1038/scientificamerican0794-58	journal	July 1994
Recent advances with liposomes as pharmaceutical carriers Torchilin, Vladimir P. Nature Reviews Drug Discovery, Vol. 4, Issue 2 https://doi.org/10.1038/nrd1632	journal	February 2005
Immunotoxin therapy of cancer Pastan, Ira; Hassan, Raffit; FitzGerald, David J. Nature Reviews Cancer, Vol. 6, Issue 7 https://doi.org/10.1038/nrc1891	journal	July 2006
Membrane Permeabilization and Efficient Gene Transfer by a Peptide Containing Several Histidines Midoux, Patrick; Kichler, Antoine; Boutin, Valérie Bioconjugate Chemistry, Vol. 9, Issue 2 https://doi.org/10.1021/bc9701611	journal	March 1998
Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery Liu, Juewen; Jiang, Xingmao; Ashley, Carlee Journal of the American Chemical Society, Vol. 131, Issue 22, p. 7567-7569 https://doi.org/10.1021/ja902039y	journal	June 2009
The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers Ashley, Carlee E.; Carnes, Eric C.; Phillips, Genevieve K. Nature Materials, Vol. 10, Issue 5, p. 389-397 https://doi.org/10.1038/nmat2992	journal	April 2011
Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain Milligan, Erin D.; Soderquist, Ryan G.; Malone, Stephanie M. Neuron Glia Biology, Vol. 2, Issue 4 https://doi.org/10.1017/S1740925X07000488	journal	November 2006
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man Bennett, Gary J.; Xie, Y.-K. Pain, Vol. 33, Issue 1, p. 87-107 https://doi.org/10.1016/0304-3959(88)90209-6	journal	January 1988
A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats Chacur, Marucia; Milligan, Erin D.; Gazda, Lawrence S. Pain, Vol. 94, Issue 3 https://doi.org/10.1016/S0304-3959(01)00354-2	journal	January 2001
Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120 Milligan, Erin D.; Mehmert, Kristin K.; Hinde, Justin L. Brain Research, Vol. 861, Issue 1, p. 105-116 https://doi.org/10.1016/S0006-8993(00)02050-3	journal	April 2000
Pathological and protective roles of glia in chronic pain Milligan, Erin D.; Watkins, Linda R. Nature Reviews Neuroscience, Vol. 10, Issue 1 https://doi.org/10.1038/nrn2533	journal	January 2009
Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration Soderquist, Ryan Gene; Sloane, Evan M.; Loram, Lisa C. Pharmaceutical Research, Vol. 27, Issue 5 https://doi.org/10.1007/s11095-010-0077-y	journal	March 2010
Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain Sloane, E.; Langer, S.; Jekich, B. Gene Therapy, Vol. 16, Issue 10 https://doi.org/10.1038/gt.2009.79	journal	July 2009
Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers Ashley, Carlee E.; Carnes, Eric C.; Epler, Katharine E. ACS Nano, Vol. 6, Issue 3 https://doi.org/10.1021/nn204102q	journal	February 2012
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord Dengler, Ellen C.; Liu, Juewen; Kerwin, Audra Journal of Controlled Release, Vol. 168, Issue 2, p. 209-224 https://doi.org/10.1016/j.jconrel.2013.03.009	journal	June 2013
Delivery of Ricin Toxin A-Chain by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers Epler, Katharine; Padilla, David; Phillips, Genevieve Advanced Healthcare Materials, Vol. 1, Issue 3, p. 348-353 https://doi.org/10.1002/adhm.201200022	journal	April 2012
Mesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility Tarn, Derrick; Ashley, Carlee E.; Xue, Min Accounts of Chemical Research, Vol. 46, Issue 3 https://doi.org/10.1021/ar3000986	journal	July 2012
Biomimetic Molecular Assemblies on Glass and Mesoporous Silica Microbeads for Biotechnology Buranda, Tione; Huang, Jinman; Ramarao, G. V. Langmuir, Vol. 19, Issue 5 https://doi.org/10.1021/la026405+	journal	January 2003
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers Slowing, I.; Vivero-Escoto, J.; Wu, C. Advanced Drug Delivery Reviews, Vol. 60, Issue 11, p. 1278-1288 https://doi.org/10.1016/j.addr.2008.03.012	journal	August 2008

Similar Records

Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Patent · Tue Nov 01 00:00:00 EDT 2016 · OSTI ID:1177123

Brinker, Jeffrey C.; Ashley, Carlee Erin; Jiang, Xingmao; +6 more

Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells

Journal Article · Fri Jul 15 00:00:00 EDT 2016 · ACS Nano · OSTI ID:1177123

Durfee, Paul N.; Lin, Yu-Shen; Dunphy, Darren R.; +11 more

Ligand-targeted theranostic nanomedicines against cancer

Journal Article · Sat Oct 01 00:00:00 EDT 2016 · Journal of Controlled Release · OSTI ID:1177123

Yao, Virginia J.; D'Angelo, Sara; Butler, Kimberly S.; +10 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES

Title: Protocells and their use for targeted delivery of multicomponent cargos to cancer cells

Citation Formats

References (24)

Similar Records

Related Subjects