Rapid classification of biological components

Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

Title: Rapid classification of biological components

Patent · Tue Oct 15 00:00:00 EDT 2013

OSTI ID:1176725

Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

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Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC07-051D14517; AC07-94ID13223; AC07-99ID13727

Assignee:: United States Department of Energy (Washington, DC)

Patent Number(s):: RE44,539

Application Number:: 13/425,181

OSTI ID:: 1176725

Resource Relation:: Patent File Date: 2012 Mar 20

Country of Publication:: United States

Language:: English

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