Supramolecular assembly of multifunctional maspin-mimetic nanostructures as a potent peptide-based angiogenesis inhibitor

Zha, R. Helen; Sur, Shantanu; Boekhoven, Job; Shi, Heidi Y.; Zhang, Ming; Stupp, Samuel I.

doi:10.1016/j.actbio.2014.11.001

Title: Supramolecular assembly of multifunctional maspin-mimetic nanostructures as a potent peptide-based angiogenesis inhibitor

Journal Article · Sat Nov 08 00:00:00 EST 2014 · Acta Biomaterialia

DOI:https://doi.org/10.1016/j.actbio.2014.11.001· OSTI ID:1168848

Zha, R. Helen ^[1]; Sur, Shantanu ^[2]; Boekhoven, Job ^[2]; Shi, Heidi Y. ^[3]; Zhang, Ming ^[3]; Stupp, Samuel I. ^[4]

Northwestern Univ., Evanston, IL (United States). Dept. of Materials Science and Engineering; Northwestern Univ., Evanston, IL (United States). Simpson Querrey Inst. for BioNanotechnology
Northwestern Univ., Evanston, IL (United States). Simpson Querrey Inst. for BioNanotechnology
Northwestern Univ., Evanston, IL (United States). Dept. of Molecular Pharmacology and Biological Chemistry
Northwestern Univ., Evanston, IL (United States). Dept. of Materials Science and Engineering; Northwestern Univ., Evanston, IL (United States). Dept. of Chemistry; Northwestern Univ., Evanston, IL (United States). Simpson Querrey Inst. for BioNanotechnology; Northwestern Univ., Evanston, IL (United States). Dept. of Medicine

Aberrant angiogenesis plays a large role in pathologies ranging from tumor growth to macular degeneration. Anti-angiogenic proteins have thus come under scrutiny as versatile, potent therapeutics but face problems with purification and tissue retention. We report here on the synthesis of supramolecular nanostructures that mimic the anti-angiogenic activity of maspin, a class II tumor suppressor protein. These maspin-mimetic nanostructures are formed via self-assembly of small peptide amphiphiles containing the g-helix motif of maspin. Using tubulogenesis assays with human umbilical vein endothelial cells, we demonstrate that maspin-mimetic nanostructures show anti-angiogenic activity at concentrations that are significantly lower than those necessary for the g-helix peptide. Furthermore, in vivo assays in the chick chorioallantoic membrane show maspin-mimetic nanostructures to be effective over controls at inhibiting angiogenesis. Thus, in conclusion, the nanostructures investigated here offer an attractive alternative to the use of anti-angiogenic recombinant proteins in the treatment of cancer or other diseases involving abnormal blood vessel formation.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC); National Institutes of Health (NIH); National Cancer Institute (NCI)

Grant/Contract Number:: AC02-06CH11357; NCI CA060553; 5U54CA151880-03; CA079736

OSTI ID:: 1168848

Alternate ID(s):: OSTI ID: 1251696

Journal Information:: Acta Biomaterialia, Vol. 12, Issue C; ISSN 1742-7061

Publisher:: Acta Materialia, Inc.Copyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 21 works

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Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility Newcomb, Christina J.; Sur, Shantanu; Lee, Sungsoo S. Nano Letters, Vol. 16, Issue 5 https://doi.org/10.1021/acs.nanolett.6b00054	journal	April 2016

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59 BASIC BIOLOGICAL SCIENCES
peptide amphiphile
self-assembly
maspin
g-Helix
anti-angiogenic

Title: Supramolecular assembly of multifunctional maspin-mimetic nanostructures as a potent peptide-based angiogenesis inhibitor

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