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Title: Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)

Abstract

Here we report a conceptual study and computational evaluation of novel planar electrode Structures for Lossless Ion Manipulations (SLIM). Planar electrode SLIM devices were designed that allow for flexible ion confinement, transport and storage using a combination of RF and DC fields. Effective potentials can be generated that provide near ideal regions for confining ions in the presence of a gas. Ion trajectory simulations using SIMION 8.1 demonstrated the capability for lossless ion motion in these devices over a wide m/z range and a range of electric fields at low pressures (e.g. a few torr). More complex ion manipulations, e.g. turning ions by 90° and dynamically switching selected ion species into orthogonal channels, are also feasible. Lastly, the performance of SLIM devices at ~4 torr pressure for performing ion mobility based separations (IMS) is computationally evaluated and compared to initial experimental results, and both of which agree closely with experimental and theoretical IMS performance for a conventional drift tube design.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1166834
Report Number(s):
PNNL-SA-103104
Journal ID: ISSN 1044-0305; 48135; 47418; 46206; 400412000
Grant/Contract Number:  
AC05-76RL01830; P41 GM103493; R21 GM103497
Resource Type:
Journal Article: Accepted Manuscript
Journal Name:
Journal of the American Society for Mass Spectrometry
Additional Journal Information:
Journal Volume: 25; Journal Issue: 11; Journal ID: ISSN 1044-0305
Publisher:
American Society for Mass Spectrometry
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; Gas phase ions; lossless manipulations; ion trajectory simulations; ion mobility; resolving power; Environmental Molecular Sciences Laboratory

Citation Formats

Garimella, Sandilya V. B, Ibrahim, Yehia M., Webb, Ian K., Tolmachev, Aleksey V., Zhang, Xinyu, Prost, Spencer A., Anderson, Gordon A., and Smith, Richard D. Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM). United States: N. p., 2014. Web. doi:10.1007/s13361-014-0976-y.
Garimella, Sandilya V. B, Ibrahim, Yehia M., Webb, Ian K., Tolmachev, Aleksey V., Zhang, Xinyu, Prost, Spencer A., Anderson, Gordon A., & Smith, Richard D. Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM). United States. https://doi.org/10.1007/s13361-014-0976-y
Garimella, Sandilya V. B, Ibrahim, Yehia M., Webb, Ian K., Tolmachev, Aleksey V., Zhang, Xinyu, Prost, Spencer A., Anderson, Gordon A., and Smith, Richard D. 2014. "Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)". United States. https://doi.org/10.1007/s13361-014-0976-y. https://www.osti.gov/servlets/purl/1166834.
@article{osti_1166834,
title = {Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)},
author = {Garimella, Sandilya V. B and Ibrahim, Yehia M. and Webb, Ian K. and Tolmachev, Aleksey V. and Zhang, Xinyu and Prost, Spencer A. and Anderson, Gordon A. and Smith, Richard D.},
abstractNote = {Here we report a conceptual study and computational evaluation of novel planar electrode Structures for Lossless Ion Manipulations (SLIM). Planar electrode SLIM devices were designed that allow for flexible ion confinement, transport and storage using a combination of RF and DC fields. Effective potentials can be generated that provide near ideal regions for confining ions in the presence of a gas. Ion trajectory simulations using SIMION 8.1 demonstrated the capability for lossless ion motion in these devices over a wide m/z range and a range of electric fields at low pressures (e.g. a few torr). More complex ion manipulations, e.g. turning ions by 90° and dynamically switching selected ion species into orthogonal channels, are also feasible. Lastly, the performance of SLIM devices at ~4 torr pressure for performing ion mobility based separations (IMS) is computationally evaluated and compared to initial experimental results, and both of which agree closely with experimental and theoretical IMS performance for a conventional drift tube design.},
doi = {10.1007/s13361-014-0976-y},
url = {https://www.osti.gov/biblio/1166834}, journal = {Journal of the American Society for Mass Spectrometry},
issn = {1044-0305},
number = 11,
volume = 25,
place = {United States},
year = {Fri Sep 26 00:00:00 EDT 2014},
month = {Fri Sep 26 00:00:00 EDT 2014}
}

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Cited by: 41 works
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Works referenced in this record:

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Works referencing / citing this record:

Ultra-high-resolution ion mobility spectrometry—current instrumentation, limitations, and future developments
journal, April 2019


Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses
journal, November 2018


Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations
journal, December 2014