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Title: Therapeutic potential of nanoceria in regenerative medicine

Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging or trauma. Advancement of tissue engineering requires innovation in the field of 3D scaffolding, and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates which can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.
 [1] ;  [2] ;  [1] ;  [3] ;  [3] ;  [4] ;  [5] ;  [1] ;  [1]
  1. Univ. of Central Florida, Orlando, FL (United States)
  2. U.S. Food and Drug Administration, Silver Spring, MD (United States)
  3. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  4. Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)
  5. National Inst. on Aging Intramural Research Program, Bethesda, MD (United States)
Publication Date:
OSTI Identifier:
Report Number(s):
Journal ID: ISSN 0025-5408; 44899; 44635; 400412000
DOE Contract Number:
Resource Type:
Journal Article
Resource Relation:
Journal Name: Materials Research Bulletin; Journal Volume: 39; Journal Issue: 11
Research Org:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org:
Country of Publication:
United States
59 BASIC BIOLOGICAL SCIENCES cerium oxide nanoparticles; regenerative medicine; tissue engineering; antioxidant; wound healing; stem cell differentiation; polymer-ceramic scaffold; Environmental Molecular Sciences Laboratory