On the Ionization and Ion Transmission Efficiencies of Different ESI-MS Interfaces
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
It is well known that the achievable sensitivity of electrospray ionization mass spectrometry (ESI-MS) is largely determined by the ionization efficiency in the ESI source and ion transmission efficiency through the ESI-MS interface. In this report we systematically study the ion transmission and ionization efficiencies in different ESI-MS interface configurations. The configurations under investigation include a single emitter/single inlet capillary, single emitter/multi-inlet capillary, and a subambient pressure ionization with nanoelectrospray (SPIN) MS interfaces with a single emitter and an emitter array, respectively. We present an effective method to evaluate the overall ion utilization efficiency of an ESI-MS interface by measuring the total gas phase ion current transmitted through the interface and correlating it to the observed ion abundance measured in the corresponding mass spectrum. Our experimental results suggest that the overall ion utilization efficiency in the SPIN-MS interface configurations is better than that in the inlet capillary based ESI-MS interface configurations.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE; National Institutes of Health (NIH)
- Grant/Contract Number:
- AC05-76RL01830; AC05-76RLO01830; 1R33CA155252; GM103493-12
- OSTI ID:
- 1166814
- Report Number(s):
- PNNL-SA-103142; 47301; 48135; 47418; 400412000
- Journal Information:
- Journal of the American Society for Mass Spectrometry, Vol. 26, Issue 1; ISSN 1044-0305
- Publisher:
- American Society for Mass SpectrometryCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
A new concept for searching for time-reversal symmetry violation using Pa-229 ions trapped in optical crystals
|
journal | March 2019 |
Similar Records
High Sensitivity Combined with Extended Structural Coverage of Labile Compounds via Nanoelectrospray Ionization at Subambient Pressures
Array of Chemically Etched Fused Silica Emitters for Improving the Sensitivity and Quantitation of Electrospray Ionization Mass Spectrometry