Producing a trimethylpentanoic acid using hybrid polyketide synthases

Katz, Leonard; Fortman, Jeffrey L; Keasling, Jay D

Title: Producing a trimethylpentanoic acid using hybrid polyketide synthases

Patent · Tue Oct 07 00:00:00 EDT 2014

OSTI ID:1160210

Katz, Leonard; Fortman, Jeffrey L; Keasling, Jay D

The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host cell of the present invention, and culturing said host cell in a suitable culture medium such that the trimethylpentanoic acid is produced, optionally isolating the trimethylpentanoic acid, and optionally, reducing the isolated trimethylpentanoic acid into a trimethylpentanol or an iso-octane.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,852,902

Application Number:: 13/302,966

OSTI ID:: 1160210

Resource Relation:: Patent File Date: 2011 Nov 22

Country of Publication:: United States

Language:: English

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