skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex

Journal Article · · Biochemistry
DOI:https://doi.org/10.1021/bi500600m· OSTI ID:1160154
 [1];  [2];  [1]
  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, United States
  2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, United States, Department of Chemistry, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel
+ Show Author Affiliations

Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
AC02-98CH10886
OSTI ID:
1160154
Journal Information:
Biochemistry, Journal Name: Biochemistry Vol. 53 Journal Issue: 41; ISSN 0006-2960
Publisher:
American Chemical SocietyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 2 works
Citation information provided by
Web of Science

References (29)

ATHENA , ARTEMIS , HEPHAESTUS : data analysis for X-ray absorption spectroscopy using IFEFFIT journal June 2005
Translation initiation: structures, mechanisms and evolution journal November 2004
Molecular Crowding Enhanced ATPase Activity of the RNA Helicase eIF4A Correlates with Compaction of Its Quaternary Structure and Association with eIF4G journal June 2013
A Conserved HEAT Domain within eIF4G Directs Assembly of the Translation Initiation Machinery journal January 2001
Crystal structure of the eIF4A-PDCD4 complex journal February 2009
Characterization of eukaryotic initiation factor 4A, a protein involved in ATP-dependent binding of globin mRNA. journal May 1982
Purification and Characterization of a New Eukaryotic Protein Translation Factor journal March 1998
Coupled Folding during Translation Initiation journal December 2003
The DEAD Box Protein eIF4A. 1. A Minimal Kinetic and Thermodynamic Framework Reveals Coupled Binding of RNA and Nucleotide † journal February 1998
Isomeric equilibria in complexes of adenosine 5'-triphosphate with divalent metal ions. Solution structures of M(ATP)2- complexes journal May 1987
Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites journal May 2009
Bent out of Shape: RNA Unwinding by the DEAD-Box Helicase Vasa journal April 2006
The ATPase Cycle Mechanism of the DEAD-box rRNA Helicase, DbpA journal March 2008
eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism journal November 2010
Helicases: amino acid sequence comparisons and structure-function relationships journal June 1993
Interaction between the NH2-terminal Domain of eIF4A and the Central Domain of eIF4G Modulates RNA-stimulated ATPase Activity journal January 2005
The ATP-dependent interaction of eukaryotic initiation factors with mRNA. journal March 1987
Crystal structure of the yeast eIF4A-eIF4G complex: An RNA-helicase controlled by protein-protein interactions journal July 2008
Backbone resonance assignment of the HEAT1-domain of the human eukaryotic translation initiation factor 4GI journal January 2013
Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation journal February 2009
mRNA helicases: the tacticians of translational control journal March 2011
RNA-stimulated ATPase activity of eukaryotic initiation factors. journal July 1984
NMRPipe: A multidimensional spectral processing system based on UNIX pipes journal November 1995
DNA Recognition by the DNA Primase of Bacteriophage T7: A Structure−Function Study of the Zinc-Binding Domain journal February 2009
Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase journal November 2000
Birth of the D-E-A-D box journal January 1989
Structural basis for the enhancement of eIF4A helicase activity by eIF4G journal September 2005
The Molecular Mechanics of Eukaryotic Translation journal June 2004
Binding of Mn-deoxyribonucleoside triphosphates to the active site of the DNA polymerase of bacteriophage T7 journal June 2011

Similar Records

Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex
Journal Article · Tue Oct 21 00:00:00 EDT 2014 · Biochemistry · OSTI ID:1160154
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Journal Article · Thu Aug 14 00:00:00 EDT 2014 · Proc. Natl. Acad. Sci. USA · OSTI ID:1160154
+13 more
Photoaffinity labeling of the cap-binding protein complex with ATP/dATP. Differential labeling of free eukaryotic initiation factor 4A and the eukaryotic initiation factor 4A component of the cap-binding protein complex with (alpha-TSP)ATP/dATP
Journal Article · Tue Nov 05 00:00:00 EST 1985 · J. Biol. Chem.; (United States) · OSTI ID:1160154

Related Subjects