Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Garabalino, Marcela A.; Heber, Elisa M.; Monti Hughes, Andrea; Pozzi, Emiliano C.C.; Molinari, Ana J.; Nigg, David W.; Bauer, William; Trivillin, Verónica A.; Schwint, Amanda E.

doi:10.1016/j.apradiso.2013.11.118

Title: Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Journal Article · Sun Jun 01 00:00:00 EDT 2014 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2013.11.118· OSTI ID:1156921

Garabalino, Marcela A.; Heber, Elisa M.; Monti Hughes, Andrea; Pozzi, Emiliano C.C.; Molinari, Ana J.; Nigg, David W.; Bauer, William; Trivillin, Verónica A.; Schwint, Amanda E.

Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70–85 ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.

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Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: DE-AC07-05ID14517

OSTI ID:: 1156921

Report Number(s):: INL/JOU-14-33084

Journal Information:: Applied Radiation and Isotopes, Vol. 88; ISSN 0969-8043

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

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Title: Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

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