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Title: Plant isoflavone and isoflavanone O-methyltransferase genes

Patent ·
OSTI ID:1150638
; ;

The invention provides enzymes that encode O-methyltransferases (OMTs) from Medicago truncatula that allow modification to plant (iso)flavonoid biosynthetic pathways. In certain aspects of the invention, the genes encoding these enzymes are provided. The invention therefore allows the modification of plants for isoflavonoid content. Transgenic plants comprising such enzymes are also provided, as well as methods for improving disease resistance in plants. Methods for producing food and nutraceuticals, and the resulting compositions, are also provided.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE
Assignee:
The Samuel Roberts Noble Foundation (Ardmore, OK)
Patent Number(s):
8,809,627
Application Number:
11/840,032
OSTI ID:
1150638
Country of Publication:
United States
Language:
English

References (15)

Isoflavonoid methylation enzyme patent April 2005
A new, structurally nonredundant, diverse data set of protein-protein interfaces and its implications journal April 2004
Protein tolerance to random amino acid change journal June 2004
Additivity of mutational effects in proteins journal September 1990
Characterization of Phenylpropene O -Methyltransferases from Sweet Basil : Facile Change of Substrate Specificity and Convergent Evolution within a Plant journal February 2002
Predicting the substrates of cloned plant O-methyltransferases journal January 2002
cDNA Cloning and Biochemical Characterization of S-Adenosyl-l-Methionine: 2,7,4′-Trihydroxyisoflavanone 4′-O-Methyltransferase, a Critical Enzyme of the Legume Isoflavonoid Phytoalexin Pathway journal February 2003
Generation of 7137 Non-redundant Expressed Sequence Tags from a Legume, Lotus japonicus journal January 2000
Combinatorial biochemistry in plants: the case of O-methyltransferases journal January 2001
Affinity Chromatography, Substrate/Product Specificity, and Amino Acid Sequence Analysis of an IsoflavoneO-Methyltransferase from Alfalfa (Medicago sativaL.) journal December 1996
Stress responses in alfalfa (Medicago sativa L). XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase journal January 1998
Conserved sequence motifs in plant S-adenosyl-L-methionine-dependent methyltransferases journal January 1998
Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli journal September 2005
Flavonoid methylation: a novel 4$prime;-O-methyltransferase from Catharanthus roseus, and evidence that partially methylated flavanones are substrates of four different flavonoid dioxygenases journal April 2004
Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula journal December 2004

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