What Have "Omics" Taught Us about the Health Risks Associated with Exposure to Low Doses of Ionizing Radiation
There is a plethora of data available on the DNA damages associated with exposures to ionizing radiation and the subsequent cellular responses. Indeed, much of radiation research has focused on these initial insults and induced responses, particularly DNA repair, cell signaling pathways, cell cycle checkpoint control, mutation induction, chromosomal rearrangements, transformation and apoptosis etc. While many of these endpoints correlate with exposure dose, few, if any, provide substantive information on human health risk(s) associated with radiation exposure. Here the contribution of recent advances in high throughput ‘omics technologies are evaluated to examine what they have taught us about health risk(s) to humans associated with exposure to ionizing radiation.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1149677
- Report Number(s):
- PNNL-SA-71557; KP1602020
- Resource Relation:
- Related Information: Cancer Risk Evaluation: Methods and Trends, 233-244
- Country of Publication:
- United States
- Language:
- English
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