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Title: Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19

Abstract

Eight comparative anchor loci on human chromosome 17, TP53, CHRNB1, THRA1, CRYB1, NF1, MPO, MYL4, and P4HB, were mapped to bovine chromosome 19 using bovine x hamster and bovine x mouse hybrid somatic cell lines. This completes the synteny mapping of human chromosome 17 comparative anchor loci in cattle, all of which have been mapped to bovine chromosome 19 and mouse chromosome 11, with the exception of CSH1. It is likely that the suggested homologue of human CSH1, PL1 on cattle chromosome 23, is a not true homologue of the human gene. This study reveals the largest conserved synteny segment among human, cattle, and mouse autosomes described to date. While all of the genes mapped to cattle chromosome 19 are on human chromosome 17, genes on mouse chromosome 11 are distributed on 7 human chromosomes, supporting the hypothesis that there is greater conservation of synteny between human and bovine chromosomes than between human and mouse. 37 refs., 2 figs., 2 tabs.

Authors:
;  [1]
  1. Texas A&M Univ., College Station, TX (United States)
Publication Date:
OSTI Identifier:
114839
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 27; Journal Issue: 2; Other Information: PBD: 20 May 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN CHROMOSOME 17; GENETIC MAPPING; CATTLE; CHROMOSOMES; DNA HYBRIDIZATION; POLYMERASE CHAIN REACTION

Citation Formats

Yang, Y P, and Womack, J E. Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19. United States: N. p., 1995. Web. doi:10.1006/geno.1995.1045.
Yang, Y P, & Womack, J E. Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19. United States. https://doi.org/10.1006/geno.1995.1045
Yang, Y P, and Womack, J E. 1995. "Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19". United States. https://doi.org/10.1006/geno.1995.1045.
@article{osti_114839,
title = {Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19},
author = {Yang, Y P and Womack, J E},
abstractNote = {Eight comparative anchor loci on human chromosome 17, TP53, CHRNB1, THRA1, CRYB1, NF1, MPO, MYL4, and P4HB, were mapped to bovine chromosome 19 using bovine x hamster and bovine x mouse hybrid somatic cell lines. This completes the synteny mapping of human chromosome 17 comparative anchor loci in cattle, all of which have been mapped to bovine chromosome 19 and mouse chromosome 11, with the exception of CSH1. It is likely that the suggested homologue of human CSH1, PL1 on cattle chromosome 23, is a not true homologue of the human gene. This study reveals the largest conserved synteny segment among human, cattle, and mouse autosomes described to date. While all of the genes mapped to cattle chromosome 19 are on human chromosome 17, genes on mouse chromosome 11 are distributed on 7 human chromosomes, supporting the hypothesis that there is greater conservation of synteny between human and bovine chromosomes than between human and mouse. 37 refs., 2 figs., 2 tabs.},
doi = {10.1006/geno.1995.1045},
url = {https://www.osti.gov/biblio/114839}, journal = {Genomics},
number = 2,
volume = 27,
place = {United States},
year = {Sat May 20 00:00:00 EDT 1995},
month = {Sat May 20 00:00:00 EDT 1995}
}