Decaying radiolabelled lymphocytes and method of using same background of the invention
Decaying radiolabelled lymphocytes and a method of using same are disclosed. A radiolabelled T-cell lymphocyte including a T-cell containing a Beta-emitting isotope which decays to an alpha-emitting isotope is provided. Alternatively, the T-cell may contain a Beta-emitting isotope which decays one of an x-ray and gamma-emitting isotope. A therapeutic radioisotope treatment method includes the steps of removing a cancerous nodule containing T-cells from a mammal, introducing into the T-cells a Beta-emitting isotope which decays to an alpha-emitting isotope and infusing the T-cells containing the Beta-emitting isotope which decays to an alpha-emitting isotope into the mammal. As an alternative, the treatment method may introduce into the T-cells a Beta-emitting isotope which decays to an x-ray or gamma-emitting isotope. Then, according to the alternative method, after the radioactive T- cells are infused into the mammal, the patient is monitored with a radiation detector to determine the location of T-cells containing the isotopes.
- Research Organization:
- Department of the Navy, Washington, DC (United States)
- Assignee:
- Department of the Navy, Washington, DC
- Application Number:
- PAN: 8-366,637; TRN: 52611385
- OSTI ID:
- 113797
- Resource Relation:
- Other Information: PBD: 30 Dec 1994
- Country of Publication:
- United States
- Language:
- English
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