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Title: Split of Chiral Degeneracy in Mechanical and Structural Properties of Oligopeptide-Polysaccharide Biomaterials

Enantiomeric biomaterials which are mirror images of each other are characterized by chiral degeneracy—identical structural characteristics and bulk material properties. The addition of another chiral component, d-polysaccharide, has been shown to split such degeneracy and result in two distinct biomaterials. Dynamic oscillatory rheometry and small-angle X-ray scattering demonstrate that the natural biochirality combination of l-peptides and d-polysaccharides assembles faster, has higher elastic moduli (G'), and is structurally more beneficial as opposed to the alternative d-peptide and d-polysaccharide combination. Chemical modifications of the OH-groups in α-d-glucose units in d-polysaccharides weaken such splitting of chiral degeneracy. These findings form a basis to design novel biomaterials and provide additional insight on why proteins and polysaccharides have oppoiste chirality in the biological world.
; ;  [1]
  1. Maryland
Publication Date:
OSTI Identifier:
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biomacromolecules; Journal Volume: 14; Journal Issue: (9) ; 09, 2013
American Chemical Society
Research Org:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Org:
Country of Publication:
United States