Dynamic Multiscale Boundary Conditions for 4D CT Images of Healthy and Emphysematous Rat

Journal Article · Fri Jun 14 00:00:00 EDT 2013 · PLoS One, 8(6):Article No. e65874

DOI:https://doi.org/10.1371/journal.pone.0065874· OSTI ID:1086391

Jacob, Rick E.; Carson, James P.; Thomas, Mathew; Einstein, Daniel R.

Changes in the shape of the lung during breathing determine the movement of airways and alveoli, and thus impact airflow dynamics. Modeling airflow dynamics in health and disease is a key goal for predictive multiscale models of respiration. Past efforts to model changes in lung shape during breathing have measured shape at multiple breath-holds. However, breath-holds do not capture hysteretic differences between inspiration and expiration resulting from the additional energy required for inspiration. Alternatively, imaging dynamically – without breath-holds – allows measurement of hysteretic differences. In this study, we acquire multiple micro-CT images per breath (4DCT) in live rats, and from these images we develop, for the first time, dynamic volume maps. These maps show changes in local volume across the entire lung throughout the breathing cycle and accurately predict the global pressure-volume (PV) hysteresis.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1086391
• Report Number(s): PNNL-SA-91208; 400412000
• Journal Information: PLoS One, 8(6):Article No. e65874, Journal Name: PLoS One, 8(6):Article No. e65874
• Country of Publication: United States
• Language: English