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Title: Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature

Abstract

Introduction Much of the work addressing ionizing radiation-induced cellular response has been carried out mainly with the traditional cell culture technique involving only one cell type, how cellular response to IR is influenced by the tissue microenvironment remains elusive. By use of a three-dimensional (3D) co-culture system to model critical interactions of different cell types with their neighbors and with their environment, we recently showed that low-dose IR-induced extracellular signaling via the tissue environment affects profoundly cellular responses. This proposal aims at determining the response of mammary epithelial cells in a tissue-like setting.

Authors:
 [1]
  1. Harvard School of Public Health
Publication Date:
Research Org.:
Harvard School of Public Health
Sponsoring Org.:
USDOE
Contributing Org.:
Harvard School of Public Health
OSTI Identifier:
1076860
Report Number(s):
Final Report
275-23495-111384
DOE Contract Number:  
FG02-05ER64116
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Low doses radiation, senescence, microenvironment

Citation Formats

Yuan, Zhi-Min. Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature. United States: N. p., 2013. Web. doi:10.2172/1076860.
Yuan, Zhi-Min. Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature. United States. https://doi.org/10.2172/1076860
Yuan, Zhi-Min. 2013. "Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature". United States. https://doi.org/10.2172/1076860. https://www.osti.gov/servlets/purl/1076860.
@article{osti_1076860,
title = {Low Dose IR Creates an Oncogenic Microenvironment by Inducing Premature},
author = {Yuan, Zhi-Min},
abstractNote = {Introduction Much of the work addressing ionizing radiation-induced cellular response has been carried out mainly with the traditional cell culture technique involving only one cell type, how cellular response to IR is influenced by the tissue microenvironment remains elusive. By use of a three-dimensional (3D) co-culture system to model critical interactions of different cell types with their neighbors and with their environment, we recently showed that low-dose IR-induced extracellular signaling via the tissue environment affects profoundly cellular responses. This proposal aims at determining the response of mammary epithelial cells in a tissue-like setting.},
doi = {10.2172/1076860},
url = {https://www.osti.gov/biblio/1076860}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Apr 28 00:00:00 EDT 2013},
month = {Sun Apr 28 00:00:00 EDT 2013}
}