Functionalized PEI Nanoparticles For Delivery Of IGF-1R-Targeted siRNA's to UPAR-Expressing Tumors In Vitro And In Vivo
This proposal addressed the use of imaging technologies to develop therapeutic nanoparticle constructs which could reduce expression of molecules within the cancer cell important in tumor progression. The proposal described new labeling techniques that would result in therapeutic constructs which could be tracked both within targeted cells individually as well as within the individuals being treated. Representing a new generation of dual-labeled in vivo imaging agent, the constructs envisioned here would allow microPET imaging of targeted receptor expression as well as fluorescent imaging of silencing complexes targeting IGF-1R mRNA's. As such, this proposal was highly relevant to the Office of Biological and Environmental Research (BER) goals of facilitating improvements in radiotracer design in order to solve critical problems in biology and nuclear medicine.
- Research Organization:
- University of Missouri System, OSPA, 310 Jesse Hall, Columbia MO
- Sponsoring Organization:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- DOE Contract Number:
- SC0002117
- OSTI ID:
- 1057389
- Report Number(s):
- DOESC02117
- Country of Publication:
- United States
- Language:
- English
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