QB1 - Stochastic Gene Regulation
Conference
·
OSTI ID:1047096
- Los Alamos National Laboratory
Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present in the cell - Random motion and competition between reactants, Low copy, quantization of reactants, Upstream processes; (2) Fluctuations may be very important - Cell-to-cell variability, Cell fate decisions (switches), Signal amplification or damping, stochastic resonances; and (3) Some tools are available to mode these - Kinetic Monte Carlo simulations (SSA and variants), Moment approximation methods, Finite State Projection. We will see how modeling these reactions can tell us more about the underlying processes of gene regulation.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE Laboratory Directed Research and Development (LDRD) Program
- DOE Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1047096
- Report Number(s):
- LA-UR-12-23277; TRN: US201215%%747
- Resource Relation:
- Conference: q-bio Summer School ; 2012-07-23 - 2012-07-23 ; Santa Fe, New Mexico, United States
- Country of Publication:
- United States
- Language:
- English
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