QB1 - Stochastic Gene Regulation
Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present in the cell - Random motion and competition between reactants, Low copy, quantization of reactants, Upstream processes; (2) Fluctuations may be very important - Cell-to-cell variability, Cell fate decisions (switches), Signal amplification or damping, stochastic resonances; and (3) Some tools are available to mode these - Kinetic Monte Carlo simulations (SSA and variants), Moment approximation methods, Finite State Projection. We will see how modeling these reactions can tell us more about the underlying processes of gene regulation.
- Publication Date:
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- Conference: q-bio Summer School ; 2012-07-23 - 2012-07-23 ; Santa Fe, New Mexico, United States
- Research Org:
- Los Alamos National Laboratory (LANL)
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- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; AMPLIFICATION; APPROXIMATIONS; DAMPING; EDUCATIONAL FACILITIES; FLUCTUATIONS; GENE REGULATION; KINETICS; QUANTIZATION; SIMULATION; SWITCHES
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