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Title: QB1 - Stochastic Gene Regulation

QB1 - Stochastic Gene Regulation Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present in the cell - Random motion and competition between reactants, Low copy, quantization of reactants, Upstream processes; (2) Fluctuations may be very important - Cell-to-cell variability, Cell fate decisions (switches), Signal amplification or damping, stochastic resonances; and (3) Some tools are available to mode these - Kinetic Monte Carlo simulations (SSA and variants), Moment approximation methods, Finite State Projection. We will see how modeling these reactions can tell us more about the underlying processes of gene regulation.
Authors:
Publication Date:
OSTI Identifier:1047096
Report Number(s):LA-UR-12-23277
TRN: US201215%%747
DOE Contract Number:AC52-06NA25396
Resource Type:Conference
Data Type:
Resource Relation:Conference: q-bio Summer School ; 2012-07-23 - 2012-07-23 ; Santa Fe, New Mexico, United States
Research Org:Los Alamos National Laboratory (LANL)
Sponsoring Org:LDRD
Country of Publication:United States
Language:English
Subject: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; AMPLIFICATION; APPROXIMATIONS; DAMPING; EDUCATIONAL FACILITIES; FLUCTUATIONS; GENE REGULATION; KINETICS; QUANTIZATION; SIMULATION; SWITCHES