Replication of N[superscript 2],3-Ethenoguanine by DNA Polymerases
Journal Article
·
· Angewandte Chemie (International Edition)
- Vanderbilt
The unstable DNA adduct N2,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA polymerases, in terms of both the biochemistry of the lesion and a structure of the lesion within a polymerase.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Sponsoring Organization:
- OTHER U.S. GOVERNMENT
- OSTI ID:
- 1043730
- Journal Information:
- Angewandte Chemie (International Edition), Vol. 51, Issue (22) ; 05, 2012; ISSN 1433-7851
- Country of Publication:
- United States
- Language:
- ENGLISH
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